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Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study

Nils Swindell, Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo, Jeffrey Stephens Orcid Logo, Diewertje Sluik, Mikael Fogelholm, Mathijs Drummen, Ian MacDonald, J. Alfredo Martinez, Teodora Handjieva-Darlenska, Sally D. Poppitt, Jennie Brand-Miller, Thomas M. Larsen, Anne Raben, Gareth Stratton Orcid Logo

Diabetes Care, Volume: 41, Issue: 3, Pages: 562 - 569

Swansea University Authors: Nils Swindell, Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo, Jeffrey Stephens Orcid Logo, Gareth Stratton Orcid Logo

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DOI (Published version): 10.2337/dc17-1057

Abstract

OBJECTIVE The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes.RESEARCH DESIGN AND METHODS Participants (n = 2,326; 25–70 years old, 67% female) from eight countries, with a...

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Published in: Diabetes Care
ISSN: 0149-5992 1935-5548
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa36626
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2021-01-14T13:52:24.8902779</datestamp><bib-version>v2</bib-version><id>36626</id><entry>2017-11-07</entry><title>Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study</title><swanseaauthors><author><sid>d89a0a3fb118e1cf625fddc68cdf25bb</sid><firstname>Nils</firstname><surname>Swindell</surname><name>Nils Swindell</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>bdb20e3f31bcccf95c7bc116070c4214</sid><ORCID>0000-0003-0355-6357</ORCID><firstname>Kelly</firstname><surname>Mackintosh</surname><name>Kelly Mackintosh</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>062f5697ff59f004bc8c713955988398</sid><ORCID>0000-0003-0813-7477</ORCID><firstname>Melitta</firstname><surname>McNarry</surname><name>Melitta McNarry</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>5219d126f97f8f884bdb622099bd41de</sid><ORCID>0000-0003-2228-086X</ORCID><firstname>Jeffrey</firstname><surname>Stephens</surname><name>Jeffrey Stephens</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>6d62b2ed126961bed81a94a2beba8a01</sid><ORCID>0000-0001-5618-0803</ORCID><firstname>Gareth</firstname><surname>Stratton</surname><name>Gareth Stratton</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2017-11-07</date><deptcode>ISSS</deptcode><abstract>OBJECTIVE The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes.RESEARCH DESIGN AND METHODS Participants (n = 2,326; 25&#x2013;70 years old, 67% female) from eight countries, with a BMI &gt;25 kg &#x22C5; m&#x2212;2 and impaired fasting glucose (5.6&#x2013;6.9 mmol &#x22C5; L&#x2212;1) or impaired glucose tolerance (7.8&#x2013;11.0 mmol &#x22C5; L&#x2212;1 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST.RESULTS Multiple linear regression revealed that moderate-to-vigorous PA (MVPA) was negatively associated with HOMA of insulin resistance (HOMA-IR) (standardized &#x3B2; = &#x2212;0.078 [95% CI &#x2212;0.128, &#x2212;0.027]), waist circumference (WC) (&#x3B2; = &#x2212;0.177 [&#x2212;0.122, &#x2212;0.134]), fasting insulin (&#x3B2; = &#x2212;0.115 [&#x2212;0.158, &#x2212;0.072]), 2-h glucose (&#x3B2; = &#x2212;0.069 [&#x2212;0.112, &#x2212;0.025]), triglycerides (&#x3B2; = &#x2212;0.091 [&#x2212;0.138, &#x2212;0.044]), and CRP (&#x3B2; = &#x2212;0.086 [&#x2212;0.127, &#x2212;0.045]). ST was positively associated with HOMA-IR (&#x3B2; = 0.175 [0.114, 0.236]), WC (&#x3B2; = 0.215 [0.026, 0.131]), fasting insulin (&#x3B2; = 0.155 [0.092, 0.219]), triglycerides (&#x3B2; = 0.106 [0.052, 0.16]), CRP (&#x3B2; = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (&#x3B2; = 0.078 [0.026, 0.131]), and diastolic BP (&#x3B2; = 0.106 [0.39, &#x2212;0.172]). Associations reported between total PA (counts &#x22C5; min&#x2212;1) and all risk factors were comparable or stronger than for MVPA: HOMA-IR (&#x3B2; = &#x2212;0.151 [&#x2212;0.194, &#x2212;0.107]), WC (&#x3B2; = &#x2212;0.179 [&#x2212;0.224, &#x2212;0.134]), fasting insulin (&#x3B2; = &#x2212;0.139 [&#x2212;0.183, &#x2212;0.096]), 2-h glucose (&#x3B2; = &#x2212;0.088 [&#x2212;0.131, &#x2212;0.045]), triglycerides (&#x3B2; = &#x2212;0.117 [&#x2212;0.162, &#x2212;0.071]), and CRP (&#x3B2; = &#x2212;0.104 [&#x2212;0.146, &#x2212;0.062]).CONCLUSIONS In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.</abstract><type>Journal Article</type><journal>Diabetes Care</journal><volume>41</volume><journalNumber>3</journalNumber><paginationStart>562</paginationStart><paginationEnd>569</paginationEnd><publisher/><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0149-5992</issnPrint><issnElectronic>1935-5548</issnElectronic><keywords/><publishedDay>1</publishedDay><publishedMonth>3</publishedMonth><publishedYear>2018</publishedYear><publishedDate>2018-03-01</publishedDate><doi>10.2337/dc17-1057</doi><url/><notes/><college>COLLEGE NANME</college><department>Inclusive Student Support Services</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>ISSS</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2021-01-14T13:52:24.8902779</lastEdited><Created>2017-11-07T10:33:33.2188492</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Uncategorised</level></path><authors><author><firstname>Nils</firstname><surname>Swindell</surname><order>1</order></author><author><firstname>Kelly</firstname><surname>Mackintosh</surname><orcid>0000-0003-0355-6357</orcid><order>2</order></author><author><firstname>Melitta</firstname><surname>McNarry</surname><orcid>0000-0003-0813-7477</orcid><order>3</order></author><author><firstname>Jeffrey</firstname><surname>Stephens</surname><orcid>0000-0003-2228-086X</orcid><order>4</order></author><author><firstname>Diewertje</firstname><surname>Sluik</surname><order>5</order></author><author><firstname>Mikael</firstname><surname>Fogelholm</surname><order>6</order></author><author><firstname>Mathijs</firstname><surname>Drummen</surname><order>7</order></author><author><firstname>Ian</firstname><surname>MacDonald</surname><order>8</order></author><author><firstname>J. Alfredo</firstname><surname>Martinez</surname><order>9</order></author><author><firstname>Teodora</firstname><surname>Handjieva-Darlenska</surname><order>10</order></author><author><firstname>Sally D.</firstname><surname>Poppitt</surname><order>11</order></author><author><firstname>Jennie</firstname><surname>Brand-Miller</surname><order>12</order></author><author><firstname>Thomas M.</firstname><surname>Larsen</surname><order>13</order></author><author><firstname>Anne</firstname><surname>Raben</surname><order>14</order></author><author><firstname>Gareth</firstname><surname>Stratton</surname><orcid>0000-0001-5618-0803</orcid><order>15</order></author></authors><documents><document><filename>0036626-07112017103559.pdf</filename><originalFilename>swindell2017.pdf</originalFilename><uploaded>2017-11-07T10:35:59.4870000</uploaded><type>Output</type><contentLength>518258</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2017-11-07T00:00:00.0000000</embargoDate><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2021-01-14T13:52:24.8902779 v2 36626 2017-11-07 Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study d89a0a3fb118e1cf625fddc68cdf25bb Nils Swindell Nils Swindell true false bdb20e3f31bcccf95c7bc116070c4214 0000-0003-0355-6357 Kelly Mackintosh Kelly Mackintosh true false 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false 5219d126f97f8f884bdb622099bd41de 0000-0003-2228-086X Jeffrey Stephens Jeffrey Stephens true false 6d62b2ed126961bed81a94a2beba8a01 0000-0001-5618-0803 Gareth Stratton Gareth Stratton true false 2017-11-07 ISSS OBJECTIVE The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes.RESEARCH DESIGN AND METHODS Participants (n = 2,326; 25–70 years old, 67% female) from eight countries, with a BMI >25 kg ⋅ m−2 and impaired fasting glucose (5.6–6.9 mmol ⋅ L−1) or impaired glucose tolerance (7.8–11.0 mmol ⋅ L−1 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST.RESULTS Multiple linear regression revealed that moderate-to-vigorous PA (MVPA) was negatively associated with HOMA of insulin resistance (HOMA-IR) (standardized β = −0.078 [95% CI −0.128, −0.027]), waist circumference (WC) (β = −0.177 [−0.122, −0.134]), fasting insulin (β = −0.115 [−0.158, −0.072]), 2-h glucose (β = −0.069 [−0.112, −0.025]), triglycerides (β = −0.091 [−0.138, −0.044]), and CRP (β = −0.086 [−0.127, −0.045]). ST was positively associated with HOMA-IR (β = 0.175 [0.114, 0.236]), WC (β = 0.215 [0.026, 0.131]), fasting insulin (β = 0.155 [0.092, 0.219]), triglycerides (β = 0.106 [0.052, 0.16]), CRP (β = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (β = 0.078 [0.026, 0.131]), and diastolic BP (β = 0.106 [0.39, −0.172]). Associations reported between total PA (counts ⋅ min−1) and all risk factors were comparable or stronger than for MVPA: HOMA-IR (β = −0.151 [−0.194, −0.107]), WC (β = −0.179 [−0.224, −0.134]), fasting insulin (β = −0.139 [−0.183, −0.096]), 2-h glucose (β = −0.088 [−0.131, −0.045]), triglycerides (β = −0.117 [−0.162, −0.071]), and CRP (β = −0.104 [−0.146, −0.062]).CONCLUSIONS In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA. Journal Article Diabetes Care 41 3 562 569 0149-5992 1935-5548 1 3 2018 2018-03-01 10.2337/dc17-1057 COLLEGE NANME Inclusive Student Support Services COLLEGE CODE ISSS Swansea University 2021-01-14T13:52:24.8902779 2017-11-07T10:33:33.2188492 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised Nils Swindell 1 Kelly Mackintosh 0000-0003-0355-6357 2 Melitta McNarry 0000-0003-0813-7477 3 Jeffrey Stephens 0000-0003-2228-086X 4 Diewertje Sluik 5 Mikael Fogelholm 6 Mathijs Drummen 7 Ian MacDonald 8 J. Alfredo Martinez 9 Teodora Handjieva-Darlenska 10 Sally D. Poppitt 11 Jennie Brand-Miller 12 Thomas M. Larsen 13 Anne Raben 14 Gareth Stratton 0000-0001-5618-0803 15 0036626-07112017103559.pdf swindell2017.pdf 2017-11-07T10:35:59.4870000 Output 518258 application/pdf Accepted Manuscript true 2017-11-07T00:00:00.0000000 true eng
title Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study
spellingShingle Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study
Nils Swindell
Kelly Mackintosh
Melitta McNarry
Jeffrey Stephens
Gareth Stratton
title_short Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study
title_full Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study
title_fullStr Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study
title_full_unstemmed Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study
title_sort Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study
author_id_str_mv d89a0a3fb118e1cf625fddc68cdf25bb
bdb20e3f31bcccf95c7bc116070c4214
062f5697ff59f004bc8c713955988398
5219d126f97f8f884bdb622099bd41de
6d62b2ed126961bed81a94a2beba8a01
author_id_fullname_str_mv d89a0a3fb118e1cf625fddc68cdf25bb_***_Nils Swindell
bdb20e3f31bcccf95c7bc116070c4214_***_Kelly Mackintosh
062f5697ff59f004bc8c713955988398_***_Melitta McNarry
5219d126f97f8f884bdb622099bd41de_***_Jeffrey Stephens
6d62b2ed126961bed81a94a2beba8a01_***_Gareth Stratton
author Nils Swindell
Kelly Mackintosh
Melitta McNarry
Jeffrey Stephens
Gareth Stratton
author2 Nils Swindell
Kelly Mackintosh
Melitta McNarry
Jeffrey Stephens
Diewertje Sluik
Mikael Fogelholm
Mathijs Drummen
Ian MacDonald
J. Alfredo Martinez
Teodora Handjieva-Darlenska
Sally D. Poppitt
Jennie Brand-Miller
Thomas M. Larsen
Anne Raben
Gareth Stratton
format Journal article
container_title Diabetes Care
container_volume 41
container_issue 3
container_start_page 562
publishDate 2018
institution Swansea University
issn 0149-5992
1935-5548
doi_str_mv 10.2337/dc17-1057
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
document_store_str 1
active_str 0
description OBJECTIVE The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes.RESEARCH DESIGN AND METHODS Participants (n = 2,326; 25–70 years old, 67% female) from eight countries, with a BMI >25 kg ⋅ m−2 and impaired fasting glucose (5.6–6.9 mmol ⋅ L−1) or impaired glucose tolerance (7.8–11.0 mmol ⋅ L−1 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST.RESULTS Multiple linear regression revealed that moderate-to-vigorous PA (MVPA) was negatively associated with HOMA of insulin resistance (HOMA-IR) (standardized β = −0.078 [95% CI −0.128, −0.027]), waist circumference (WC) (β = −0.177 [−0.122, −0.134]), fasting insulin (β = −0.115 [−0.158, −0.072]), 2-h glucose (β = −0.069 [−0.112, −0.025]), triglycerides (β = −0.091 [−0.138, −0.044]), and CRP (β = −0.086 [−0.127, −0.045]). ST was positively associated with HOMA-IR (β = 0.175 [0.114, 0.236]), WC (β = 0.215 [0.026, 0.131]), fasting insulin (β = 0.155 [0.092, 0.219]), triglycerides (β = 0.106 [0.052, 0.16]), CRP (β = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (β = 0.078 [0.026, 0.131]), and diastolic BP (β = 0.106 [0.39, −0.172]). Associations reported between total PA (counts ⋅ min−1) and all risk factors were comparable or stronger than for MVPA: HOMA-IR (β = −0.151 [−0.194, −0.107]), WC (β = −0.179 [−0.224, −0.134]), fasting insulin (β = −0.139 [−0.183, −0.096]), 2-h glucose (β = −0.088 [−0.131, −0.045]), triglycerides (β = −0.117 [−0.162, −0.071]), and CRP (β = −0.104 [−0.146, −0.062]).CONCLUSIONS In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.
published_date 2018-03-01T03:45:55Z
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