Journal article 1269 views 186 downloads
Reducing Calorie Intake May Not Help You Lose Body Weight
David Benton,
Hayley Young 
Perspectives on Psychological Science, Volume: 12, Pages: 703 - 714
Swansea University Authors:
David Benton, Hayley Young
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DOI (Published version): 10.1177/1745691617690878
Abstract
Background Previously a meta-analysis found that multi-vitamin/mineral supplementation reduced mild psychiatric symptoms. To establish mechanisms, and to pin-point the individuals most likely to benefit, the role of various polymorphisms were examined. Supplementation was found to influence mild-psy...
| Published in: | Perspectives on Psychological Science |
|---|---|
| ISSN: | 1745-6916 1745-6924 |
| Published: |
2017
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa33939 |
| first_indexed |
2017-05-25T20:05:20Z |
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2020-12-10T03:46:22Z |
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<?xml version="1.0"?><rfc1807><datestamp>2020-12-09T09:53:29.6621548</datestamp><bib-version>v2</bib-version><id>33939</id><entry>2017-05-25</entry><title>Reducing Calorie Intake May Not Help You Lose Body Weight</title><swanseaauthors><author><sid>7845ee79286c74b7939198c94e9e16ff</sid><firstname>David</firstname><surname>Benton</surname><name>David Benton</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>22748f1a953255d63cb6ab9a98c11d70</sid><ORCID>0000-0002-6954-3519</ORCID><firstname>Hayley</firstname><surname>Young</surname><name>Hayley Young</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2017-05-25</date><abstract>Background Previously a meta-analysis found that multi-vitamin/mineral supplementation reduced mild psychiatric symptoms. To establish mechanisms, and to pin-point the individuals most likely to benefit, the role of various polymorphisms were examined. Supplementation was found to influence mild-psychiatric symptoms depending on the form of particular genes: genes that are risk factors for psychiatric disease and influence mechanisms by which drugs act. Methods In a double-blind trial young healthy males rated psychiatric symptoms, before and after taking vitamin/mineral supplements for three months, and the response was related to single nucleotide polymorphisms associated with catecholamines and serotonin. Outcomes With rs1800497 (Taq1A; dopamine D2 receptor), those with the CT allele benefitted from a vitamin/mineral supplement. Similarly with rs1800955 (DRD4 – dopamine D4 receptor), the mood of those with the CC allele benefitted selectively. With rs6296 (HTR1B) only those with the GC alleles responded, and with rs6311 (HTR2A) supplementation produced a beneficial response in those with the GG allele. With rs1050565 (5HTT gene - Human Serotonin Transporter gene) supplementation increased the mental health of those with the AA allele. Interpretation In a situation where a substantial proportion of patients do not benefit from drug therapy, and there is an element of trial and error when prescribing, it was proposed that future work should consider distinguishing patients depending on various polymorphisms and micro-nutrient status. In those with particular alleles, we should consider if drug administration and vitamin / mineral status interact synergistically to influence the therapeutic outcome</abstract><type>Journal Article</type><journal>Perspectives on Psychological Science</journal><volume>12</volume><journalNumber/><paginationStart>703</paginationStart><paginationEnd>714</paginationEnd><publisher/><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1745-6916</issnPrint><issnElectronic>1745-6924</issnElectronic><keywords/><publishedDay>28</publishedDay><publishedMonth>6</publishedMonth><publishedYear>2017</publishedYear><publishedDate>2017-06-28</publishedDate><doi>10.1177/1745691617690878</doi><url/><notes/><college>COLLEGE NANME</college><CollegeCode>COLLEGE CODE</CollegeCode><institution>Swansea University</institution><apcterm/><lastEdited>2020-12-09T09:53:29.6621548</lastEdited><Created>2017-05-25T14:17:31.6017524</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Psychology</level></path><authors><author><firstname>David</firstname><surname>Benton</surname><order>1</order></author><author><firstname>Hayley</firstname><surname>Young</surname><orcid>0000-0002-6954-3519</orcid><order>2</order></author></authors><documents><document><filename>0033939-03072017113446.pdf</filename><originalFilename>1745691617690878.pdf</originalFilename><uploaded>2017-07-03T11:34:46.9000000</uploaded><type>Output</type><contentLength>705956</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><embargoDate>2017-06-28T00:00:00.0000000</embargoDate><documentNotes>This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807> |
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2020-12-09T09:53:29.6621548 v2 33939 2017-05-25 Reducing Calorie Intake May Not Help You Lose Body Weight 7845ee79286c74b7939198c94e9e16ff David Benton David Benton true false 22748f1a953255d63cb6ab9a98c11d70 0000-0002-6954-3519 Hayley Young Hayley Young true false 2017-05-25 Background Previously a meta-analysis found that multi-vitamin/mineral supplementation reduced mild psychiatric symptoms. To establish mechanisms, and to pin-point the individuals most likely to benefit, the role of various polymorphisms were examined. Supplementation was found to influence mild-psychiatric symptoms depending on the form of particular genes: genes that are risk factors for psychiatric disease and influence mechanisms by which drugs act. Methods In a double-blind trial young healthy males rated psychiatric symptoms, before and after taking vitamin/mineral supplements for three months, and the response was related to single nucleotide polymorphisms associated with catecholamines and serotonin. Outcomes With rs1800497 (Taq1A; dopamine D2 receptor), those with the CT allele benefitted from a vitamin/mineral supplement. Similarly with rs1800955 (DRD4 – dopamine D4 receptor), the mood of those with the CC allele benefitted selectively. With rs6296 (HTR1B) only those with the GC alleles responded, and with rs6311 (HTR2A) supplementation produced a beneficial response in those with the GG allele. With rs1050565 (5HTT gene - Human Serotonin Transporter gene) supplementation increased the mental health of those with the AA allele. Interpretation In a situation where a substantial proportion of patients do not benefit from drug therapy, and there is an element of trial and error when prescribing, it was proposed that future work should consider distinguishing patients depending on various polymorphisms and micro-nutrient status. In those with particular alleles, we should consider if drug administration and vitamin / mineral status interact synergistically to influence the therapeutic outcome Journal Article Perspectives on Psychological Science 12 703 714 1745-6916 1745-6924 28 6 2017 2017-06-28 10.1177/1745691617690878 COLLEGE NANME COLLEGE CODE Swansea University 2020-12-09T09:53:29.6621548 2017-05-25T14:17:31.6017524 Faculty of Medicine, Health and Life Sciences School of Psychology David Benton 1 Hayley Young 0000-0002-6954-3519 2 0033939-03072017113446.pdf 1745691617690878.pdf 2017-07-03T11:34:46.9000000 Output 705956 application/pdf Version of Record true 2017-06-28T00:00:00.0000000 This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License. true eng |
| title |
Reducing Calorie Intake May Not Help You Lose Body Weight |
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Reducing Calorie Intake May Not Help You Lose Body Weight David Benton Hayley Young |
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Reducing Calorie Intake May Not Help You Lose Body Weight |
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Reducing Calorie Intake May Not Help You Lose Body Weight |
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Reducing Calorie Intake May Not Help You Lose Body Weight |
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Reducing Calorie Intake May Not Help You Lose Body Weight |
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Reducing Calorie Intake May Not Help You Lose Body Weight |
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Perspectives on Psychological Science |
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Background Previously a meta-analysis found that multi-vitamin/mineral supplementation reduced mild psychiatric symptoms. To establish mechanisms, and to pin-point the individuals most likely to benefit, the role of various polymorphisms were examined. Supplementation was found to influence mild-psychiatric symptoms depending on the form of particular genes: genes that are risk factors for psychiatric disease and influence mechanisms by which drugs act. Methods In a double-blind trial young healthy males rated psychiatric symptoms, before and after taking vitamin/mineral supplements for three months, and the response was related to single nucleotide polymorphisms associated with catecholamines and serotonin. Outcomes With rs1800497 (Taq1A; dopamine D2 receptor), those with the CT allele benefitted from a vitamin/mineral supplement. Similarly with rs1800955 (DRD4 – dopamine D4 receptor), the mood of those with the CC allele benefitted selectively. With rs6296 (HTR1B) only those with the GC alleles responded, and with rs6311 (HTR2A) supplementation produced a beneficial response in those with the GG allele. With rs1050565 (5HTT gene - Human Serotonin Transporter gene) supplementation increased the mental health of those with the AA allele. Interpretation In a situation where a substantial proportion of patients do not benefit from drug therapy, and there is an element of trial and error when prescribing, it was proposed that future work should consider distinguishing patients depending on various polymorphisms and micro-nutrient status. In those with particular alleles, we should consider if drug administration and vitamin / mineral status interact synergistically to influence the therapeutic outcome |
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2017-06-28T04:12:51Z |
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11.04748 |