Reducing Calorie Intake May Not Help You Lose Body Weight

Benton, David; Young, Hayley

doi:10.1177/1745691617690878

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Reducing Calorie Intake May Not Help You Lose Body Weight

David Benton, Hayley Young

Perspectives on Psychological Science, Volume: 12, Pages: 703 - 714

Swansea University Authors: David Benton, Hayley Young

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DOI (Published version): 10.1177/1745691617690878

Abstract

Background Previously a meta-analysis found that multi-vitamin/mineral supplementation reduced mild psychiatric symptoms. To establish mechanisms, and to pin-point the individuals most likely to benefit, the role of various polymorphisms were examined. Supplementation was found to influence mild-psy...

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Published in:	Perspectives on Psychological Science
ISSN:	1745-6916 1745-6924
Published:	2017
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa33939
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first_indexed	2017-05-25T20:05:20Z
last_indexed	2020-12-10T03:46:22Z
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spelling	2020-12-09T09:53:29.6621548 v2 33939 2017-05-25 Reducing Calorie Intake May Not Help You Lose Body Weight 7845ee79286c74b7939198c94e9e16ff David Benton David Benton true false 22748f1a953255d63cb6ab9a98c11d70 Hayley Young Hayley Young true false 2017-05-25 FGMHL Background Previously a meta-analysis found that multi-vitamin/mineral supplementation reduced mild psychiatric symptoms. To establish mechanisms, and to pin-point the individuals most likely to benefit, the role of various polymorphisms were examined. Supplementation was found to influence mild-psychiatric symptoms depending on the form of particular genes: genes that are risk factors for psychiatric disease and influence mechanisms by which drugs act. Methods In a double-blind trial young healthy males rated psychiatric symptoms, before and after taking vitamin/mineral supplements for three months, and the response was related to single nucleotide polymorphisms associated with catecholamines and serotonin. Outcomes With rs1800497 (Taq1A; dopamine D2 receptor), those with the CT allele benefitted from a vitamin/mineral supplement. Similarly with rs1800955 (DRD4 – dopamine D4 receptor), the mood of those with the CC allele benefitted selectively. With rs6296 (HTR1B) only those with the GC alleles responded, and with rs6311 (HTR2A) supplementation produced a beneficial response in those with the GG allele. With rs1050565 (5HTT gene - Human Serotonin Transporter gene) supplementation increased the mental health of those with the AA allele. Interpretation In a situation where a substantial proportion of patients do not benefit from drug therapy, and there is an element of trial and error when prescribing, it was proposed that future work should consider distinguishing patients depending on various polymorphisms and micro-nutrient status. In those with particular alleles, we should consider if drug administration and vitamin / mineral status interact synergistically to influence the therapeutic outcome Journal Article Perspectives on Psychological Science 12 703 714 1745-6916 1745-6924 28 6 2017 2017-06-28 10.1177/1745691617690878 COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University 2020-12-09T09:53:29.6621548 2017-05-25T14:17:31.6017524 Faculty of Medicine, Health and Life Sciences School of Psychology David Benton 1 Hayley Young 2 0033939-03072017113446.pdf 1745691617690878.pdf 2017-07-03T11:34:46.9000000 Output 705956 application/pdf Version of Record true 2017-06-28T00:00:00.0000000 This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License. true eng
title	Reducing Calorie Intake May Not Help You Lose Body Weight
spellingShingle	Reducing Calorie Intake May Not Help You Lose Body Weight David Benton Hayley Young
title_short	Reducing Calorie Intake May Not Help You Lose Body Weight
title_full	Reducing Calorie Intake May Not Help You Lose Body Weight
title_fullStr	Reducing Calorie Intake May Not Help You Lose Body Weight
title_full_unstemmed	Reducing Calorie Intake May Not Help You Lose Body Weight
title_sort	Reducing Calorie Intake May Not Help You Lose Body Weight
author_id_str_mv	7845ee79286c74b7939198c94e9e16ff 22748f1a953255d63cb6ab9a98c11d70
author_id_fullname_str_mv	7845ee79286c74b7939198c94e9e16ff_*_David Benton 22748f1a953255d63cb6ab9a98c11d70_*_Hayley Young
author	David Benton Hayley Young
author2	David Benton Hayley Young
format	Journal article
container_title	Perspectives on Psychological Science
container_volume	12
container_start_page	703
publishDate	2017
institution	Swansea University
issn	1745-6916 1745-6924
doi_str_mv	10.1177/1745691617690878
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
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hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
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description	Background Previously a meta-analysis found that multi-vitamin/mineral supplementation reduced mild psychiatric symptoms. To establish mechanisms, and to pin-point the individuals most likely to benefit, the role of various polymorphisms were examined. Supplementation was found to influence mild-psychiatric symptoms depending on the form of particular genes: genes that are risk factors for psychiatric disease and influence mechanisms by which drugs act. Methods In a double-blind trial young healthy males rated psychiatric symptoms, before and after taking vitamin/mineral supplements for three months, and the response was related to single nucleotide polymorphisms associated with catecholamines and serotonin. Outcomes With rs1800497 (Taq1A; dopamine D2 receptor), those with the CT allele benefitted from a vitamin/mineral supplement. Similarly with rs1800955 (DRD4 – dopamine D4 receptor), the mood of those with the CC allele benefitted selectively. With rs6296 (HTR1B) only those with the GC alleles responded, and with rs6311 (HTR2A) supplementation produced a beneficial response in those with the GG allele. With rs1050565 (5HTT gene - Human Serotonin Transporter gene) supplementation increased the mental health of those with the AA allele. Interpretation In a situation where a substantial proportion of patients do not benefit from drug therapy, and there is an element of trial and error when prescribing, it was proposed that future work should consider distinguishing patients depending on various polymorphisms and micro-nutrient status. In those with particular alleles, we should consider if drug administration and vitamin / mineral status interact synergistically to influence the therapeutic outcome
published_date	2017-06-28T03:42:05Z
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Reducing Calorie Intake May Not Help You Lose Body Weight

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