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Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer / J. Brett, D. Fenlon, M. Boulton, N.J. Hulbert-Williams, F.M. Walter, P. Donnelly, B. Lavery, A. Morgan, C. Morris, E. Watson, Deborah Fenlon

European Journal of Cancer Care, Volume: 27, Issue: 1

Swansea University Author: Deborah Fenlon

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DOI (Published version): 10.1111/ecc.12601

Abstract

Adherence to adjuvant endocrine therapy (AET) following breast cancer is known to be suboptimaldespite its known efficacy in reducing recurrence and mortality. This study aims toinvestigate factors associated with non-adherence and inform the development ofinterventions to support women and promote...

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Published in: European Journal of Cancer Care
ISSN: 09615423
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa32821
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Abstract: Adherence to adjuvant endocrine therapy (AET) following breast cancer is known to be suboptimaldespite its known efficacy in reducing recurrence and mortality. This study aims toinvestigate factors associated with non-adherence and inform the development ofinterventions to support women and promote adherence. A questionnaire survey to measurelevel of adherence, side effects experienced, beliefs about medicine, support received andsocio-demographic details was sent to 292 women 2-4 years post breast cancer diagnosis.Differences between non-adherers and adherers to AET were explored, and factors associatedwith intentional and unintentional non-adherence are reported. Approximately one quarter ofrespondents, 46 (22%), were non-adherers, comprising 29 (14%) intentional non-adherersand 17 (8%) unintentional non-adherers. Factors significantly associated with intentionalnon-adherence were: the presence of side effects (p<0.03), greater concerns about AET(p<0.001), and a lower perceived necessity to take AET (p<0.001). Half of the sample(105/211) reported that side effects had a moderate or high impact on their quality of life.Factors associated with unintentional non-adherence were: younger age (<65), (p<0.001),post-secondary education (p=0.046), and paid employment (p=0.031). There are distinctdifferences between intentional non-adherence and unintentional non-adherence.Differentiation between the two types of non-adherence may help tailor support and adviceinterventions
College: College of Human and Health Sciences
Issue: 1