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Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer / J. Brett, D. Fenlon, M. Boulton, N.J. Hulbert-Williams, F.M. Walter, P. Donnelly, B. Lavery, A. Morgan, C. Morris, E. Watson, Deborah Fenlon
European Journal of Cancer Care, Volume: 27, Issue: 1
Swansea University Author: Deborah Fenlon
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Adherence to adjuvant endocrine therapy (AET) following breast cancer is known to be suboptimaldespite its known efficacy in reducing recurrence and mortality. This study aims toinvestigate factors associated with non-adherence and inform the development ofinterventions to support women and promote...
|Published in:||European Journal of Cancer Care|
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Adherence to adjuvant endocrine therapy (AET) following breast cancer is known to be suboptimaldespite its known efficacy in reducing recurrence and mortality. This study aims toinvestigate factors associated with non-adherence and inform the development ofinterventions to support women and promote adherence. A questionnaire survey to measurelevel of adherence, side effects experienced, beliefs about medicine, support received andsocio-demographic details was sent to 292 women 2-4 years post breast cancer diagnosis.Differences between non-adherers and adherers to AET were explored, and factors associatedwith intentional and unintentional non-adherence are reported. Approximately one quarter ofrespondents, 46 (22%), were non-adherers, comprising 29 (14%) intentional non-adherersand 17 (8%) unintentional non-adherers. Factors significantly associated with intentionalnon-adherence were: the presence of side effects (p<0.03), greater concerns about AET(p<0.001), and a lower perceived necessity to take AET (p<0.001). Half of the sample(105/211) reported that side effects had a moderate or high impact on their quality of life.Factors associated with unintentional non-adherence were: younger age (<65), (p<0.001),post-secondary education (p=0.046), and paid employment (p=0.031). There are distinctdifferences between intentional non-adherence and unintentional non-adherence.Differentiation between the two types of non-adherence may help tailor support and adviceinterventions
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