Journal article 809 views
Iodide as an Activating Agent for Acid Chlorides in Acylation Reactions
R. Wakeham,
J. Taylor,
S. Bull,
J. Morris,
J. Williams,
Russell Wakeham 
Organic Letters, Volume: 15, Issue: 3, Pages: 702 - 705
Swansea University Author:
Russell Wakeham
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1021/ol400035f
Abstract
Acid chlorides can be activated using a simple iodide source to undergo nucleophilic attack from a variety of relatively weak nucleophiles. These include Friedel–Crafts acylation of N-methylpyrroles, N-acylation of sulfonamides, and acylation reactions of hindered phenol derivatives. The reaction is...
| Published in: | Organic Letters |
|---|---|
| ISSN: | 1523-7060 1523-7052 |
| Published: |
American Chemical Society (ACS)
2013
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa32714 |
| Abstract: |
Acid chlorides can be activated using a simple iodide source to undergo nucleophilic attack from a variety of relatively weak nucleophiles. These include Friedel–Crafts acylation of N-methylpyrroles, N-acylation of sulfonamides, and acylation reactions of hindered phenol derivatives. The reaction is believed to proceed through a transient acid iodide intermediate. |
|---|---|
| College: |
Faculty of Science and Engineering |
| Issue: |
3 |
| Start Page: |
702 |
| End Page: |
705 |