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Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins

Filipa F. Vale, Alexandra Nunes, Mónica Oleastro, João P. Gomes, Daniel A. Sampaio, Raquel Rocha, Jorge M. B. Vítor, Lars Engstrand, Ben Pascoe Orcid Logo, Elvire Berthenet, Samuel K. Sheppard, Matthew Hitchings Orcid Logo, Francis Mégraud, Jamuna Vadivelu, Philippe Lehours

Scientific Reports, Volume: 7, Start page: 42471

Swansea University Authors: Ben Pascoe Orcid Logo, Matthew Hitchings Orcid Logo

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DOI (Published version): 10.1038/srep42471

Abstract

We present the full genomic sequences, insertion sites and phylogenetic analysis of 28 prophages found in H. pylori isolates from patients of distinct disease types, ranging from gastritis to gastric cancer, and geographic origins, covering most continents. The gentic diversity of H pylori is known...

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Published in: Scientific Reports
ISSN: 2045-2322
Published: 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa32006
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spelling 2017-03-13T10:03:19.5395577 v2 32006 2017-02-17 Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins 4660c0eb7e6bfd796cd749ae713ea558 0000-0001-6376-5121 Ben Pascoe Ben Pascoe true false be98847c72c14a731c4a6b7bc02b3bcf 0000-0002-5527-4709 Matthew Hitchings Matthew Hitchings true false 2017-02-17 We present the full genomic sequences, insertion sites and phylogenetic analysis of 28 prophages found in H. pylori isolates from patients of distinct disease types, ranging from gastritis to gastric cancer, and geographic origins, covering most continents. The gentic diversity of H pylori is known to be influenced by these genomic elements including prophages who’s geneomes range from 22.6 to 33.0 Kbp. There was a high conservation of integration site shared in over 50% of cases with greater than 40% or prophage genomes harbouring insertion sequences (IS). Furthermore prophage genomes present a robust phylogeographic pattern, revealing four distinct clusters: one African, one Asian and two European prophage populations. There was evidence of recombination within the genome of some prophages, which resulted in genome mosaics composed by different populations, which may yield additional H. pylori phenotypes. Journal Article Scientific Reports 7 42471 2045-2322 16 2 2017 2017-02-16 10.1038/srep42471 http://rdcu.be/pi0q COLLEGE NANME COLLEGE CODE Swansea University 2017-03-13T10:03:19.5395577 2017-02-17T08:17:41.3320688 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Filipa F. Vale 1 Alexandra Nunes 2 Mónica Oleastro 3 João P. Gomes 4 Daniel A. Sampaio 5 Raquel Rocha 6 Jorge M. B. Vítor 7 Lars Engstrand 8 Ben Pascoe 0000-0001-6376-5121 9 Elvire Berthenet 10 Samuel K. Sheppard 11 Matthew Hitchings 0000-0002-5527-4709 12 Francis Mégraud 13 Jamuna Vadivelu 14 Philippe Lehours 15 0032006-13032017095819.pdf srep42471.pdf 2017-03-13T09:58:19.6230000 Output 1433528 application/pdf Version of Record true 2017-02-16T00:00:00.0000000 This work is licensed under a Creative Commons Attribution 4.0 International License. true eng
title Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins
spellingShingle Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins
Ben Pascoe
Matthew Hitchings
title_short Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins
title_full Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins
title_fullStr Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins
title_full_unstemmed Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins
title_sort Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins
author_id_str_mv 4660c0eb7e6bfd796cd749ae713ea558
be98847c72c14a731c4a6b7bc02b3bcf
author_id_fullname_str_mv 4660c0eb7e6bfd796cd749ae713ea558_***_Ben Pascoe
be98847c72c14a731c4a6b7bc02b3bcf_***_Matthew Hitchings
author Ben Pascoe
Matthew Hitchings
author2 Filipa F. Vale
Alexandra Nunes
Mónica Oleastro
João P. Gomes
Daniel A. Sampaio
Raquel Rocha
Jorge M. B. Vítor
Lars Engstrand
Ben Pascoe
Elvire Berthenet
Samuel K. Sheppard
Matthew Hitchings
Francis Mégraud
Jamuna Vadivelu
Philippe Lehours
format Journal article
container_title Scientific Reports
container_volume 7
container_start_page 42471
publishDate 2017
institution Swansea University
issn 2045-2322
doi_str_mv 10.1038/srep42471
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://rdcu.be/pi0q
document_store_str 1
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description We present the full genomic sequences, insertion sites and phylogenetic analysis of 28 prophages found in H. pylori isolates from patients of distinct disease types, ranging from gastritis to gastric cancer, and geographic origins, covering most continents. The gentic diversity of H pylori is known to be influenced by these genomic elements including prophages who’s geneomes range from 22.6 to 33.0 Kbp. There was a high conservation of integration site shared in over 50% of cases with greater than 40% or prophage genomes harbouring insertion sequences (IS). Furthermore prophage genomes present a robust phylogeographic pattern, revealing four distinct clusters: one African, one Asian and two European prophage populations. There was evidence of recombination within the genome of some prophages, which resulted in genome mosaics composed by different populations, which may yield additional H. pylori phenotypes.
published_date 2017-02-16T13:09:50Z
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