Journal article 1535 views
Critical Issues in Modelling Lymph Node Physiology
,
Mario Novkovic,
Lucas Onder,
Rostislav Savinkov,
Igor Sazonov ,
Rufina Tretyakova,
Daniel Watson,
Gennady Bocharov
Computation, Volume: 5, Issue: 1, Start page: 3
Swansea University Authors:
Raoul van Loon , Igor Sazonov
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.3390/computation5010003
Abstract
In this study, we discuss critical issues in modelling the structure and function of lymph nodes (LNs), with emphasis on how LN physiology is related to its multi-scale structural organization. In addition to macroscopic domains such as B-cell follicles and the T cell zone, there are vascular networ...
| Published in: | Computation |
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| ISSN: | 2079-3197 |
| Published: |
2016
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa31455 |
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| Abstract: |
In this study, we discuss critical issues in modelling the structure and function of lymph nodes (LNs), with emphasis on how LN physiology is related to its multi-scale structural organization. In addition to macroscopic domains such as B-cell follicles and the T cell zone, there are vascular networks which play a key role in the delivery of information to the inner parts of the LN, i.e., the conduit and blood microvascular networks. We propose object-oriented computational algorithms to model the 3D geometry of the fibroblastic reticular cell (FRC) network and the microvasculature. Assuming that a conduit cylinder is densely packed with collagen fibers, the computational flow study predicted that the diffusion should be a dominating process in mass transport than convective flow. The geometry models are used to analyze the lymph flow properties through the conduit network in unperturbed- and damaged states of the LN. The analysis predicts that elimination of up to 60%–90% of edges is required to stop the lymph flux. This result suggests a high degree of functional robustness of the network. |
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| College: |
Faculty of Science and Engineering |
| Issue: |
1 |
| Start Page: |
3 |