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Effects of exercise intensity on clot microstructure and mechanical properties in healthy individuals

Nia Davies, Osian Llwyd, J.V. Brugniaux, G.R. Davies, C.J. Marley, D. Hodson, Matthew Lawrence, L.A. D'Silva, R.H.K. Morris, Karl Hawkins Orcid Logo, Rhodri Williams Orcid Logo, D.M. Bailey, Adrian Evans Orcid Logo

Thrombosis Research, Volume: 143, Pages: 130 - 136

Swansea University Authors: Nia Davies, Osian Llwyd, Matthew Lawrence, Karl Hawkins Orcid Logo, Rhodri Williams Orcid Logo, Adrian Evans Orcid Logo

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DOI (Published version): 10.1016/j.thromres.2016.05.018

Abstract

BackgroundExercise is well established to lead to exercise-induced hypercoagulability, as demonstrated by kinetic coagulation markers. It remains unclear as to whether exercise-induces changes lead in clot development and increased polymerisation. Fractal dimension (df) has been shown to act as a ma...

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Published in: Thrombosis Research
ISSN: 0049-3848
Published: Elsevier BV 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa29486
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It remains unclear as to whether exercise-induces changes lead in clot development and increased polymerisation. Fractal dimension (df) has been shown to act as a marker of clot microstructure and mechanical properties, and may provide a more meaningful method of determining the relationship between exercise-induced hypercoagulability and potential clot development.Methodsdf was measured in 24 healthy individuals prior to, after 5 min of submaximal exercise, following maximal exercise, 45 min of passive recovery and following 60 min of recovery. Results were compared with conventional markers of coagulation, fibrinolysis and SEM images.ResultsSignificantly increased df was observed following exercise, returning to resting values following 60 min of recovery. The relationship between df and mature clot microstructure was confirmed by SEM: higher df was associated with dense clots formed of smaller fibrin fibres immediately following exercise compared to at rest. Conventional markers of coagulation confirmed findings of previous studies.ConclusionThis study demonstrates that df is a sensitive technique which quantifies the structure and properties of blood clots following exercise. In healthy individuals, the haemostatic balance between coagulation and fibrinolysis is maintained in equilibrium following exercise. In individuals with underlying vascular damage who participate in exercise, this equilibrium may be displaced and lead to enhanced clot formation and a prothrombotic state. df may therefore have the potential to not only quantify hypercoagulability, but may also be useful in screening these individuals.</abstract><type>Journal Article</type><journal>Thrombosis Research</journal><volume>143</volume><journalNumber/><paginationStart>130</paginationStart><paginationEnd>136</paginationEnd><publisher>Elsevier BV</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0049-3848</issnPrint><issnElectronic/><keywords/><publishedDay>1</publishedDay><publishedMonth>7</publishedMonth><publishedYear>2016</publishedYear><publishedDate>2016-07-01</publishedDate><doi>10.1016/j.thromres.2016.05.018</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders/><projectreference/><lastEdited>2022-11-02T16:18:17.9760091</lastEdited><Created>2016-08-05T13:53:07.1493577</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Nia</firstname><surname>Davies</surname><orcid/><order>1</order></author><author><firstname>Osian</firstname><surname>Llwyd</surname><orcid/><order>2</order></author><author><firstname>J.V.</firstname><surname>Brugniaux</surname><order>3</order></author><author><firstname>G.R.</firstname><surname>Davies</surname><order>4</order></author><author><firstname>C.J.</firstname><surname>Marley</surname><order>5</order></author><author><firstname>D.</firstname><surname>Hodson</surname><order>6</order></author><author><firstname>Matthew</firstname><surname>Lawrence</surname><order>7</order></author><author><firstname>L.A.</firstname><surname>D'Silva</surname><order>8</order></author><author><firstname>R.H.K.</firstname><surname>Morris</surname><order>9</order></author><author><firstname>Karl</firstname><surname>Hawkins</surname><orcid>0000-0003-0174-4151</orcid><order>10</order></author><author><firstname>Rhodri</firstname><surname>Williams</surname><orcid>0000-0002-6912-5288</orcid><order>11</order></author><author><firstname>D.M.</firstname><surname>Bailey</surname><order>12</order></author><author><firstname>Adrian</firstname><surname>Evans</surname><orcid>0000-0002-0814-5162</orcid><order>13</order></author></authors><documents><document><filename>0029486-05082016135335.pdf</filename><originalFilename>davies2016.pdf</originalFilename><uploaded>2016-08-05T13:53:35.4000000</uploaded><type>Output</type><contentLength>529064</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2017-05-20T00:00:00.0000000</embargoDate><copyrightCorrect>false</copyrightCorrect></document></documents><OutputDurs/></rfc1807>
spelling 2022-11-02T16:18:17.9760091 v2 29486 2016-08-05 Effects of exercise intensity on clot microstructure and mechanical properties in healthy individuals 977abe5c673627024e4913d034dcbc95 Nia Davies Nia Davies true false 80e65fcf935292cc5d79db7b7fd6087f Osian Llwyd Osian Llwyd true false 262d0cae7663ded863d6e2de15757f3c Matthew Lawrence Matthew Lawrence true false 77c39404a9a98c6e2283d84815cba053 0000-0003-0174-4151 Karl Hawkins Karl Hawkins true false 642bf793695f412ed932f1ea4d9bc3f1 0000-0002-6912-5288 Rhodri Williams Rhodri Williams true false 21761f6eb805546a561c9f036e85405b 0000-0002-0814-5162 Adrian Evans Adrian Evans true false 2016-08-05 BMS BackgroundExercise is well established to lead to exercise-induced hypercoagulability, as demonstrated by kinetic coagulation markers. It remains unclear as to whether exercise-induces changes lead in clot development and increased polymerisation. Fractal dimension (df) has been shown to act as a marker of clot microstructure and mechanical properties, and may provide a more meaningful method of determining the relationship between exercise-induced hypercoagulability and potential clot development.Methodsdf was measured in 24 healthy individuals prior to, after 5 min of submaximal exercise, following maximal exercise, 45 min of passive recovery and following 60 min of recovery. Results were compared with conventional markers of coagulation, fibrinolysis and SEM images.ResultsSignificantly increased df was observed following exercise, returning to resting values following 60 min of recovery. The relationship between df and mature clot microstructure was confirmed by SEM: higher df was associated with dense clots formed of smaller fibrin fibres immediately following exercise compared to at rest. Conventional markers of coagulation confirmed findings of previous studies.ConclusionThis study demonstrates that df is a sensitive technique which quantifies the structure and properties of blood clots following exercise. In healthy individuals, the haemostatic balance between coagulation and fibrinolysis is maintained in equilibrium following exercise. In individuals with underlying vascular damage who participate in exercise, this equilibrium may be displaced and lead to enhanced clot formation and a prothrombotic state. df may therefore have the potential to not only quantify hypercoagulability, but may also be useful in screening these individuals. Journal Article Thrombosis Research 143 130 136 Elsevier BV 0049-3848 1 7 2016 2016-07-01 10.1016/j.thromres.2016.05.018 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2022-11-02T16:18:17.9760091 2016-08-05T13:53:07.1493577 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Nia Davies 1 Osian Llwyd 2 J.V. Brugniaux 3 G.R. Davies 4 C.J. Marley 5 D. Hodson 6 Matthew Lawrence 7 L.A. D'Silva 8 R.H.K. Morris 9 Karl Hawkins 0000-0003-0174-4151 10 Rhodri Williams 0000-0002-6912-5288 11 D.M. Bailey 12 Adrian Evans 0000-0002-0814-5162 13 0029486-05082016135335.pdf davies2016.pdf 2016-08-05T13:53:35.4000000 Output 529064 application/pdf Accepted Manuscript true 2017-05-20T00:00:00.0000000 false
title Effects of exercise intensity on clot microstructure and mechanical properties in healthy individuals
spellingShingle Effects of exercise intensity on clot microstructure and mechanical properties in healthy individuals
Nia Davies
Osian Llwyd
Matthew Lawrence
Karl Hawkins
Rhodri Williams
Adrian Evans
title_short Effects of exercise intensity on clot microstructure and mechanical properties in healthy individuals
title_full Effects of exercise intensity on clot microstructure and mechanical properties in healthy individuals
title_fullStr Effects of exercise intensity on clot microstructure and mechanical properties in healthy individuals
title_full_unstemmed Effects of exercise intensity on clot microstructure and mechanical properties in healthy individuals
title_sort Effects of exercise intensity on clot microstructure and mechanical properties in healthy individuals
author_id_str_mv 977abe5c673627024e4913d034dcbc95
80e65fcf935292cc5d79db7b7fd6087f
262d0cae7663ded863d6e2de15757f3c
77c39404a9a98c6e2283d84815cba053
642bf793695f412ed932f1ea4d9bc3f1
21761f6eb805546a561c9f036e85405b
author_id_fullname_str_mv 977abe5c673627024e4913d034dcbc95_***_Nia Davies
80e65fcf935292cc5d79db7b7fd6087f_***_Osian Llwyd
262d0cae7663ded863d6e2de15757f3c_***_Matthew Lawrence
77c39404a9a98c6e2283d84815cba053_***_Karl Hawkins
642bf793695f412ed932f1ea4d9bc3f1_***_Rhodri Williams
21761f6eb805546a561c9f036e85405b_***_Adrian Evans
author Nia Davies
Osian Llwyd
Matthew Lawrence
Karl Hawkins
Rhodri Williams
Adrian Evans
author2 Nia Davies
Osian Llwyd
J.V. Brugniaux
G.R. Davies
C.J. Marley
D. Hodson
Matthew Lawrence
L.A. D'Silva
R.H.K. Morris
Karl Hawkins
Rhodri Williams
D.M. Bailey
Adrian Evans
format Journal article
container_title Thrombosis Research
container_volume 143
container_start_page 130
publishDate 2016
institution Swansea University
issn 0049-3848
doi_str_mv 10.1016/j.thromres.2016.05.018
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description BackgroundExercise is well established to lead to exercise-induced hypercoagulability, as demonstrated by kinetic coagulation markers. It remains unclear as to whether exercise-induces changes lead in clot development and increased polymerisation. Fractal dimension (df) has been shown to act as a marker of clot microstructure and mechanical properties, and may provide a more meaningful method of determining the relationship between exercise-induced hypercoagulability and potential clot development.Methodsdf was measured in 24 healthy individuals prior to, after 5 min of submaximal exercise, following maximal exercise, 45 min of passive recovery and following 60 min of recovery. Results were compared with conventional markers of coagulation, fibrinolysis and SEM images.ResultsSignificantly increased df was observed following exercise, returning to resting values following 60 min of recovery. The relationship between df and mature clot microstructure was confirmed by SEM: higher df was associated with dense clots formed of smaller fibrin fibres immediately following exercise compared to at rest. Conventional markers of coagulation confirmed findings of previous studies.ConclusionThis study demonstrates that df is a sensitive technique which quantifies the structure and properties of blood clots following exercise. In healthy individuals, the haemostatic balance between coagulation and fibrinolysis is maintained in equilibrium following exercise. In individuals with underlying vascular damage who participate in exercise, this equilibrium may be displaced and lead to enhanced clot formation and a prothrombotic state. df may therefore have the potential to not only quantify hypercoagulability, but may also be useful in screening these individuals.
published_date 2016-07-01T03:35:52Z
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