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Complement is activated in progressive multiple sclerosis cortical grey matter lesions

Lewis Watkins, James W. Neal, Sam Loveless, Iliana Michailidou, Valeria Ramaglia, Mark Rees, Richard Reynolds, Neil P. Robertson, B. Paul Morgan, Owain Howell Orcid Logo

Journal of Neuroinflammation, Volume: 13, Issue: 1

Swansea University Authors: Lewis Watkins, Mark Rees, Owain Howell Orcid Logo

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DOI (Published version): 10.1186/s12974-016-0611-x

Abstract

The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining...

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Published in: Journal of Neuroinflammation
ISSN: 1742-2094
Published: Springer Science and Business Media LLC 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa29210
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Abstract: The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining pathological mechanisms at play in MS grey matter is therefore a key to our understanding of disease progression.
Keywords: Complemen; Grey matter lesion; Innate immunity; Multiple sclerosis; Neurodegeneration
College: Faculty of Medicine, Health and Life Sciences
Issue: 1

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