Journal article 1773 views 253 downloads
Defining Disease Phenotypes in Primary Care Electronic Health Records by a Machine Learning Approach: A Case Study in Identifying Rheumatoid Arthritis
,
Fabiola Fernandez-Gutierrez,
Jonathan Kennedy,
Roxanne Cooksey,
Mark Atkinson ,
Spiros Denaxas,
Stefan Siebert,
William G. Dixon,
Terence W. O’Neill,
Ernest Choy,
Cathie Sudlow,
Sinead Brophy ,
(UK Biobank Follow-up and Outcomes Group)
PLOS ONE, Volume: 11, Issue: 5, Start page: e0154515
Swansea University Authors:
Shang-ming Zhou , Mark Atkinson , Sinead Brophy
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© 2016 Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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DOI (Published version): 10.1371/journal.pone.0154515
Abstract
Objectives1) To use data-driven method to examine clinical codes (risk factors) of a medical condition in primary care electronic health records (EHRs) that can accurately predict a diagnosis of the condition in secondary care EHRs. 2) To develop and validate a disease phenotyping algorithm for rheu...
| Published in: | PLOS ONE |
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| ISSN: | 1932-6203 |
| Published: |
Public Library of Science (PLoS)
2016
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa27734 |
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| Abstract: |
Objectives1) To use data-driven method to examine clinical codes (risk factors) of a medical condition in primary care electronic health records (EHRs) that can accurately predict a diagnosis of the condition in secondary care EHRs. 2) To develop and validate a disease phenotyping algorithm for rheumatoid arthritis using primary care EHRs.MethodsThis study linked routine primary and secondary care EHRs in Wales, UK. A machine learning based scheme was used to identify patients with rheumatoid arthritis from primary care EHRs via the following steps: i) selection of variables by comparing relative frequencies of Read codes in the primary care dataset associated with disease case compared to non-disease control (disease/non-disease based on the secondary care diagnosis); ii) reduction of predictors/associated variables using a Random Forest method, iii) induction of decision rules from decision tree model. The proposed method was then extensively validated on an independent dataset, and compared for performance with two existing deterministic algorithms for RA which had been developed using expert clinical knowledge.ResultsPrimary care EHRs were available for 2,238,360 patients over the age of 16 and of these 20,667 were also linked in the secondary care rheumatology clinical system. In the linked dataset, 900 predictors (out of a total of 43,100 variables) in the primary care record were discovered more frequently in those with versus those without RA. These variables were reduced to 37 groups of related clinical codes, which were used to develop a decision tree model. The final algorithm identified 8 predictors related to diagnostic codes for RA, medication codes, such as those for disease modifying anti-rheumatic drugs, and absence of alternative diagnoses such as psoriatic arthritis. The proposed data-driven method performed as well as the expert clinical knowledge based methods.ConclusionData-driven scheme, such as ensemble machine learning methods, has the potential of identifying the most informative predictors in a cost-effective and rapid way to accurately and reliably classify rheumatoid arthritis or other complex medical conditions in primary care EHRs. |
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| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
5 |
| Start Page: |
e0154515 |