Journal article 706 views
SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics
Biomechanics and Modeling in Mechanobiology, Volume: 14, Issue: 6, Pages: 1317 - 1333
Swansea University Author: Marco Ellero
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DOI (Published version): 10.1007/s10237-015-0676-y
Abstract
A multiscale Lagrangian particle solver introduced in our previous work is extended to model physiologically realistic near-wall cell dynamics. Three-dimensional simulation of particle trajectories is combined with realistic receptor–ligand adhesion behaviour to cover full cell interactions in the v...
Published in: | Biomechanics and Modeling in Mechanobiology |
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ISSN: | 1617-7959 1617-7940 |
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2015
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Online Access: |
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URI: | https://cronfa.swan.ac.uk/Record/cronfa25441 |
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2017-06-30T14:31:13.0179465 v2 25441 2016-01-07 SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics 84f2af0791d38bdbf826728de7e5c69d Marco Ellero Marco Ellero true false 2016-01-07 A multiscale Lagrangian particle solver introduced in our previous work is extended to model physiologically realistic near-wall cell dynamics. Three-dimensional simulation of particle trajectories is combined with realistic receptor–ligand adhesion behaviour to cover full cell interactions in the vicinity of the endothelium. The selected stochastic adhesion model, which is based on a Monte Carlo acceptance–rejection method, fits in our Lagrangian framework and does not compromise performance. Additionally, appropriate inflow/outflow boundary conditions are implemented for our SPH solver to enable realistic pulsatile flow simulation. The model is tested against in-vitro data from a 3D geometry with a stenosis and sudden expansion. In both steady and pulsatile flow conditions, results show close agreement with the experimental ones. Furthermore we demonstrate, in agreement with experimental observations, that haemodynamics alone does not account for adhesion of white blood cells, in this case U937 monocytic human cells. Our findings suggest that the current framework is fully capable of modelling cell dynamics in large arteries in a realistic and efficient manner. Journal Article Biomechanics and Modeling in Mechanobiology 14 6 1317 1333 1617-7959 1617-7940 Smoothed particle hydrodynamics; Cell adhesion; White blood cells; Large artery; 25 4 2015 2015-04-25 10.1007/s10237-015-0676-y http://link.springer.com/article/10.1007%2Fs10237-015-0676-y COLLEGE NANME COLLEGE CODE Swansea University 2017-06-30T14:31:13.0179465 2016-01-07T10:56:41.4655088 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised Babak Gholami 1 Andrew Comerford 2 Marco Ellero 3 |
title |
SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics |
spellingShingle |
SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics Marco Ellero |
title_short |
SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics |
title_full |
SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics |
title_fullStr |
SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics |
title_full_unstemmed |
SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics |
title_sort |
SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics |
author_id_str_mv |
84f2af0791d38bdbf826728de7e5c69d |
author_id_fullname_str_mv |
84f2af0791d38bdbf826728de7e5c69d_***_Marco Ellero |
author |
Marco Ellero |
author2 |
Babak Gholami Andrew Comerford Marco Ellero |
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Journal article |
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Biomechanics and Modeling in Mechanobiology |
container_volume |
14 |
container_issue |
6 |
container_start_page |
1317 |
publishDate |
2015 |
institution |
Swansea University |
issn |
1617-7959 1617-7940 |
doi_str_mv |
10.1007/s10237-015-0676-y |
college_str |
Faculty of Science and Engineering |
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|
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facultyofscienceandengineering |
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Faculty of Science and Engineering |
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facultyofscienceandengineering |
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Faculty of Science and Engineering |
department_str |
School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised |
url |
http://link.springer.com/article/10.1007%2Fs10237-015-0676-y |
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description |
A multiscale Lagrangian particle solver introduced in our previous work is extended to model physiologically realistic near-wall cell dynamics. Three-dimensional simulation of particle trajectories is combined with realistic receptor–ligand adhesion behaviour to cover full cell interactions in the vicinity of the endothelium. The selected stochastic adhesion model, which is based on a Monte Carlo acceptance–rejection method, fits in our Lagrangian framework and does not compromise performance. Additionally, appropriate inflow/outflow boundary conditions are implemented for our SPH solver to enable realistic pulsatile flow simulation. The model is tested against in-vitro data from a 3D geometry with a stenosis and sudden expansion. In both steady and pulsatile flow conditions, results show close agreement with the experimental ones. Furthermore we demonstrate, in agreement with experimental observations, that haemodynamics alone does not account for adhesion of white blood cells, in this case U937 monocytic human cells. Our findings suggest that the current framework is fully capable of modelling cell dynamics in large arteries in a realistic and efficient manner. |
published_date |
2015-04-25T05:46:51Z |
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1836690347339546624 |
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11.067157 |