No Cover Image

Journal article 706 views

SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics

Babak Gholami, Andrew Comerford, Marco Ellero

Biomechanics and Modeling in Mechanobiology, Volume: 14, Issue: 6, Pages: 1317 - 1333

Swansea University Author: Marco Ellero

Full text not available from this repository: check for access using links below.

Abstract

A multiscale Lagrangian particle solver introduced in our previous work is extended to model physiologically realistic near-wall cell dynamics. Three-dimensional simulation of particle trajectories is combined with realistic receptor–ligand adhesion behaviour to cover full cell interactions in the v...

Full description

Published in: Biomechanics and Modeling in Mechanobiology
ISSN: 1617-7959 1617-7940
Published: 2015
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa25441
first_indexed 2016-01-08T01:53:31Z
last_indexed 2018-02-09T05:06:19Z
id cronfa25441
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2017-06-30T14:31:13.0179465</datestamp><bib-version>v2</bib-version><id>25441</id><entry>2016-01-07</entry><title>SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics</title><swanseaauthors><author><sid>84f2af0791d38bdbf826728de7e5c69d</sid><firstname>Marco</firstname><surname>Ellero</surname><name>Marco Ellero</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2016-01-07</date><abstract>A multiscale Lagrangian particle solver introduced in our previous work is extended to model physiologically realistic near-wall cell dynamics. Three-dimensional simulation of particle trajectories is combined with realistic receptor&#x2013;ligand adhesion behaviour to cover full cell interactions in the vicinity of the endothelium. The selected stochastic adhesion model, which is based on a Monte Carlo acceptance&#x2013;rejection method, fits in our Lagrangian framework and does not compromise performance. Additionally, appropriate inflow/outflow boundary conditions are implemented for our SPH solver to enable realistic pulsatile flow simulation. The model is tested against in-vitro data from a 3D geometry with a stenosis and sudden expansion. In both steady and pulsatile flow conditions, results show close agreement with the experimental ones. Furthermore we demonstrate, in agreement with experimental observations, that haemodynamics alone does not account for adhesion of white blood cells, in this case U937 monocytic human cells. Our findings suggest that the current framework is fully capable of modelling cell dynamics in large arteries in a realistic and efficient manner.</abstract><type>Journal Article</type><journal>Biomechanics and Modeling in Mechanobiology</journal><volume>14</volume><journalNumber>6</journalNumber><paginationStart>1317</paginationStart><paginationEnd>1333</paginationEnd><publisher/><issnPrint>1617-7959</issnPrint><issnElectronic>1617-7940</issnElectronic><keywords>Smoothed particle hydrodynamics; Cell adhesion; White blood cells; Large artery;</keywords><publishedDay>25</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2015</publishedYear><publishedDate>2015-04-25</publishedDate><doi>10.1007/s10237-015-0676-y</doi><url>http://link.springer.com/article/10.1007%2Fs10237-015-0676-y</url><notes/><college>COLLEGE NANME</college><CollegeCode>COLLEGE CODE</CollegeCode><institution>Swansea University</institution><apcterm/><lastEdited>2017-06-30T14:31:13.0179465</lastEdited><Created>2016-01-07T10:56:41.4655088</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Uncategorised</level></path><authors><author><firstname>Babak</firstname><surname>Gholami</surname><order>1</order></author><author><firstname>Andrew</firstname><surname>Comerford</surname><order>2</order></author><author><firstname>Marco</firstname><surname>Ellero</surname><order>3</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2017-06-30T14:31:13.0179465 v2 25441 2016-01-07 SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics 84f2af0791d38bdbf826728de7e5c69d Marco Ellero Marco Ellero true false 2016-01-07 A multiscale Lagrangian particle solver introduced in our previous work is extended to model physiologically realistic near-wall cell dynamics. Three-dimensional simulation of particle trajectories is combined with realistic receptor–ligand adhesion behaviour to cover full cell interactions in the vicinity of the endothelium. The selected stochastic adhesion model, which is based on a Monte Carlo acceptance–rejection method, fits in our Lagrangian framework and does not compromise performance. Additionally, appropriate inflow/outflow boundary conditions are implemented for our SPH solver to enable realistic pulsatile flow simulation. The model is tested against in-vitro data from a 3D geometry with a stenosis and sudden expansion. In both steady and pulsatile flow conditions, results show close agreement with the experimental ones. Furthermore we demonstrate, in agreement with experimental observations, that haemodynamics alone does not account for adhesion of white blood cells, in this case U937 monocytic human cells. Our findings suggest that the current framework is fully capable of modelling cell dynamics in large arteries in a realistic and efficient manner. Journal Article Biomechanics and Modeling in Mechanobiology 14 6 1317 1333 1617-7959 1617-7940 Smoothed particle hydrodynamics; Cell adhesion; White blood cells; Large artery; 25 4 2015 2015-04-25 10.1007/s10237-015-0676-y http://link.springer.com/article/10.1007%2Fs10237-015-0676-y COLLEGE NANME COLLEGE CODE Swansea University 2017-06-30T14:31:13.0179465 2016-01-07T10:56:41.4655088 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised Babak Gholami 1 Andrew Comerford 2 Marco Ellero 3
title SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics
spellingShingle SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics
Marco Ellero
title_short SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics
title_full SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics
title_fullStr SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics
title_full_unstemmed SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics
title_sort SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics
author_id_str_mv 84f2af0791d38bdbf826728de7e5c69d
author_id_fullname_str_mv 84f2af0791d38bdbf826728de7e5c69d_***_Marco Ellero
author Marco Ellero
author2 Babak Gholami
Andrew Comerford
Marco Ellero
format Journal article
container_title Biomechanics and Modeling in Mechanobiology
container_volume 14
container_issue 6
container_start_page 1317
publishDate 2015
institution Swansea University
issn 1617-7959
1617-7940
doi_str_mv 10.1007/s10237-015-0676-y
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
url http://link.springer.com/article/10.1007%2Fs10237-015-0676-y
document_store_str 0
active_str 0
description A multiscale Lagrangian particle solver introduced in our previous work is extended to model physiologically realistic near-wall cell dynamics. Three-dimensional simulation of particle trajectories is combined with realistic receptor–ligand adhesion behaviour to cover full cell interactions in the vicinity of the endothelium. The selected stochastic adhesion model, which is based on a Monte Carlo acceptance–rejection method, fits in our Lagrangian framework and does not compromise performance. Additionally, appropriate inflow/outflow boundary conditions are implemented for our SPH solver to enable realistic pulsatile flow simulation. The model is tested against in-vitro data from a 3D geometry with a stenosis and sudden expansion. In both steady and pulsatile flow conditions, results show close agreement with the experimental ones. Furthermore we demonstrate, in agreement with experimental observations, that haemodynamics alone does not account for adhesion of white blood cells, in this case U937 monocytic human cells. Our findings suggest that the current framework is fully capable of modelling cell dynamics in large arteries in a realistic and efficient manner.
published_date 2015-04-25T05:46:51Z
_version_ 1836690347339546624
score 11.067157