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Radiofrequency treatment alters cancer cell phenotype

Matthew J. Ware, Sophia Tinger, Kevin L. Colbert, Stuart J. Corr, Paul Rees Orcid Logo, Nadezhda Koshkina, Steven Curley, Huw Summers Orcid Logo, Biana Godin

Scientific Reports, Volume: 5, Issue: 1

Swansea University Authors: Paul Rees Orcid Logo, Huw Summers Orcid Logo

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DOI (Published version): 10.1038/srep12083

Abstract

The importance of evaluating physical cues in cancer research is gradually being realized. Assessment of cancer cell physical appearance, or phenotype, may provide information on changes in cellular behavior, including migratory or communicative changes. These characteristics are intrinsically diffe...

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Published in: Scientific Reports
ISSN: 2045-2322 2045-2322
Published: 2015
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URI: https://cronfa.swan.ac.uk/Record/cronfa25011
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first_indexed 2015-12-10T01:57:48Z
last_indexed 2021-01-15T03:41:11Z
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spelling 2021-01-14T13:14:00.1359409 v2 25011 2015-12-09 Radiofrequency treatment alters cancer cell phenotype 537a2fe031a796a3bde99679ee8c24f5 0000-0002-7715-6914 Paul Rees Paul Rees true false a61c15e220837ebfa52648c143769427 0000-0002-0898-5612 Huw Summers Huw Summers true false 2015-12-09 MEDE The importance of evaluating physical cues in cancer research is gradually being realized. Assessment of cancer cell physical appearance, or phenotype, may provide information on changes in cellular behavior, including migratory or communicative changes. These characteristics are intrinsically different between malignant and non-malignant cells and change in response to therapy or in the progression of the disease. Here, we report that pancreatic cancer cell phenotype was altered in response to a physical method for cancer therapy, a non-invasive radiofrequency (RF) treatment, which is currently being developed for human trials. We provide a battery of tests to explore these phenotype characteristics. Our data show that cell topography, morphology, motility, adhesion and division change as a result of the treatment. These may have consequences for tissue architecture, for diffusion of anti-cancer therapeutics and cancer cell susceptibility within the tumor. Clear phenotypical differences were observed between cancerous and normal cells in both their untreated states and in their response to RF therapy. We also report, for the first time, a transfer of microsized particles through tunneling nanotubes, which were produced by cancer cells in response to RF therapy. Additionally, we provide evidence that various sub-populations of cancer cells heterogeneously respond to RF treatment. Journal Article Scientific Reports 5 1 2045-2322 2045-2322 13 7 2015 2015-07-13 10.1038/srep12083 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2021-01-14T13:14:00.1359409 2015-12-09T19:56:11.6243705 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Matthew J. Ware 1 Sophia Tinger 2 Kevin L. Colbert 3 Stuart J. Corr 4 Paul Rees 0000-0002-7715-6914 5 Nadezhda Koshkina 6 Steven Curley 7 Huw Summers 0000-0002-0898-5612 8 Biana Godin 9
title Radiofrequency treatment alters cancer cell phenotype
spellingShingle Radiofrequency treatment alters cancer cell phenotype
Paul Rees
Huw Summers
title_short Radiofrequency treatment alters cancer cell phenotype
title_full Radiofrequency treatment alters cancer cell phenotype
title_fullStr Radiofrequency treatment alters cancer cell phenotype
title_full_unstemmed Radiofrequency treatment alters cancer cell phenotype
title_sort Radiofrequency treatment alters cancer cell phenotype
author_id_str_mv 537a2fe031a796a3bde99679ee8c24f5
a61c15e220837ebfa52648c143769427
author_id_fullname_str_mv 537a2fe031a796a3bde99679ee8c24f5_***_Paul Rees
a61c15e220837ebfa52648c143769427_***_Huw Summers
author Paul Rees
Huw Summers
author2 Matthew J. Ware
Sophia Tinger
Kevin L. Colbert
Stuart J. Corr
Paul Rees
Nadezhda Koshkina
Steven Curley
Huw Summers
Biana Godin
format Journal article
container_title Scientific Reports
container_volume 5
container_issue 1
publishDate 2015
institution Swansea University
issn 2045-2322
2045-2322
doi_str_mv 10.1038/srep12083
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
active_str 0
description The importance of evaluating physical cues in cancer research is gradually being realized. Assessment of cancer cell physical appearance, or phenotype, may provide information on changes in cellular behavior, including migratory or communicative changes. These characteristics are intrinsically different between malignant and non-malignant cells and change in response to therapy or in the progression of the disease. Here, we report that pancreatic cancer cell phenotype was altered in response to a physical method for cancer therapy, a non-invasive radiofrequency (RF) treatment, which is currently being developed for human trials. We provide a battery of tests to explore these phenotype characteristics. Our data show that cell topography, morphology, motility, adhesion and division change as a result of the treatment. These may have consequences for tissue architecture, for diffusion of anti-cancer therapeutics and cancer cell susceptibility within the tumor. Clear phenotypical differences were observed between cancerous and normal cells in both their untreated states and in their response to RF therapy. We also report, for the first time, a transfer of microsized particles through tunneling nanotubes, which were produced by cancer cells in response to RF therapy. Additionally, we provide evidence that various sub-populations of cancer cells heterogeneously respond to RF treatment.
published_date 2015-07-13T03:29:44Z
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score 11.01353

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