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Impaired Visuospatial Transformation but Intact Sequence Processing in Parkinson Disease

E. Charles Leek, Julie H. Kerai, Stephen Johnston Orcid Logo, John V. Hindle, R. Martyn Bracewell

Cognitive And Behavioral Neurology, Volume: 27, Issue: 3, Pages: 130 - 138

Swansea University Author: Stephen Johnston Orcid Logo

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DOI (Published version): 10.1097/WNN.0000000000000032

Abstract

Objective: We examined whether visuospatial deficits in Parkinson disease (PD) can be explained by a domain-general, nonspatial impairment in the sequencing or serial chaining of mental operations.Background: PD has been shown to be associated with impaired visuospatial processing, but the mechanism...

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Published in: Cognitive And Behavioral Neurology
Published: 2014
URI: https://cronfa.swan.ac.uk/Record/cronfa24981
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first_indexed 2015-12-08T02:01:39Z
last_indexed 2018-02-09T05:05:18Z
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spelling 2015-12-07T14:56:45.9817044 v2 24981 2015-12-07 Impaired Visuospatial Transformation but Intact Sequence Processing in Parkinson Disease a5a4e9fd4ddde98a4cc3c1e3c6fa310f 0000-0001-9360-8856 Stephen Johnston Stephen Johnston true false 2015-12-07 HPS Objective: We examined whether visuospatial deficits in Parkinson disease (PD) can be explained by a domain-general, nonspatial impairment in the sequencing or serial chaining of mental operations.Background: PD has been shown to be associated with impaired visuospatial processing, but the mechanisms of this impairment remain unclear.Methods: Thirteen patients with PD and 20 age-matched, neurologically normal controls performed a visuospatial grid navigation task requiring sequential spatial transformations. The participants also performed a control task of serial number subtraction designed to assess their nonvisuospatial sequencing. The tasks were matched in structure and difficulty.Results: The patients were impaired on the visuospatial task but not in serial number subtraction. This finding suggests that visuospatial processing impairments in PD do not derive from a general impairment affecting sequencing or serial chaining.Conclusions: We argue that visuospatial deficits in PD result from impairments to spatial transformation routines involved in the computation of mappings between spatial locations. These routines are mediated by dopaminergic pathways linking the basal ganglia, prefrontal cortex, supplementary motor area, and parietal cortex. Journal Article Cognitive And Behavioral Neurology 27 3 130 138 Parkinson&apos;s Disease, Visuo-spatial transformation, pre-SMA 31 12 2014 2014-12-31 10.1097/WNN.0000000000000032 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University 2015-12-07T14:56:45.9817044 2015-12-07T14:56:45.9817044 Faculty of Medicine, Health and Life Sciences School of Psychology E. Charles Leek 1 Julie H. Kerai 2 Stephen Johnston 0000-0001-9360-8856 3 John V. Hindle 4 R. Martyn Bracewell 5
title Impaired Visuospatial Transformation but Intact Sequence Processing in Parkinson Disease
spellingShingle Impaired Visuospatial Transformation but Intact Sequence Processing in Parkinson Disease
Stephen Johnston
title_short Impaired Visuospatial Transformation but Intact Sequence Processing in Parkinson Disease
title_full Impaired Visuospatial Transformation but Intact Sequence Processing in Parkinson Disease
title_fullStr Impaired Visuospatial Transformation but Intact Sequence Processing in Parkinson Disease
title_full_unstemmed Impaired Visuospatial Transformation but Intact Sequence Processing in Parkinson Disease
title_sort Impaired Visuospatial Transformation but Intact Sequence Processing in Parkinson Disease
author_id_str_mv a5a4e9fd4ddde98a4cc3c1e3c6fa310f
author_id_fullname_str_mv a5a4e9fd4ddde98a4cc3c1e3c6fa310f_***_Stephen Johnston
author Stephen Johnston
author2 E. Charles Leek
Julie H. Kerai
Stephen Johnston
John V. Hindle
R. Martyn Bracewell
format Journal article
container_title Cognitive And Behavioral Neurology
container_volume 27
container_issue 3
container_start_page 130
publishDate 2014
institution Swansea University
doi_str_mv 10.1097/WNN.0000000000000032
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 0
active_str 0
description Objective: We examined whether visuospatial deficits in Parkinson disease (PD) can be explained by a domain-general, nonspatial impairment in the sequencing or serial chaining of mental operations.Background: PD has been shown to be associated with impaired visuospatial processing, but the mechanisms of this impairment remain unclear.Methods: Thirteen patients with PD and 20 age-matched, neurologically normal controls performed a visuospatial grid navigation task requiring sequential spatial transformations. The participants also performed a control task of serial number subtraction designed to assess their nonvisuospatial sequencing. The tasks were matched in structure and difficulty.Results: The patients were impaired on the visuospatial task but not in serial number subtraction. This finding suggests that visuospatial processing impairments in PD do not derive from a general impairment affecting sequencing or serial chaining.Conclusions: We argue that visuospatial deficits in PD result from impairments to spatial transformation routines involved in the computation of mappings between spatial locations. These routines are mediated by dopaminergic pathways linking the basal ganglia, prefrontal cortex, supplementary motor area, and parietal cortex.
published_date 2014-12-31T03:29:42Z
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score 11.037603

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