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Materials and Substances Relating to Polyions and Substance Delivery [ChargeSwitchTM & EasyplexTM DNA Isolation Technology] US Patent 7319004 B2

Garry Harper Orcid Logo

Swansea University Author: Garry Harper Orcid Logo

Abstract

Materials and methods relating to polyions and substance delivery US 7319004 B2ABSTRACTMaterials and method are disclose for delivering a desired substance to a target site, using a layered carrier in which the carrier and the substance together form at least three layers which associate by ionic in...

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Published: 2008
Online Access: http://www.uspto.gov/
URI: https://cronfa.swan.ac.uk/Record/cronfa24319
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Abstract: Materials and methods relating to polyions and substance delivery US 7319004 B2ABSTRACTMaterials and method are disclose for delivering a desired substance to a target site, using a layered carrier in which the carrier and the substance together form at least three layers which associate by ionic interaction at the first pH, where at least one layer comprises a charge switch material which comprises an ionisable group and which has a positive charge at a first pH and a charge which is less positive, neutral or negative at a second pH, at least one layer comprises a polyionic polymer which is negatively charged at the first pH and at least one layer comprises the desired substance. Preferred carriers are based on the charge switch material poly Bis-Tris and the polyionic polymer polyacrylic acid.
College: Faculty of Science and Engineering