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Highly stable noble metal nanoparticles dispersible in biocompatible solvents: synthesis of cationic phosphonium gold nanoparticles in water and DMSO

Yon Ju-Nam Orcid Logo, Jesus Ojeda Ledo Orcid Logo

Faraday Discussions, Volume: 186, Pages: 77 - 93

Swansea University Authors: Yon Ju-Nam Orcid Logo, Jesus Ojeda Ledo Orcid Logo

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DOI (Published version): 10.1039/C5FD00131E

Abstract

In this work, we report the synthesis of novel cationic phosphonium gold nanoparticles dispersible in water and dimethyl sulfoxide (DMSO) for their potential use in biomedical applications. All the cationic-functionalising ligands currently reported in the literature are ammonium-based species. Here...

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Published in: Faraday Discussions
ISSN: 1359-6640 1364-5498
Published: 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa24082
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spelling 2020-05-22T13:55:57.7550932 v2 24082 2015-10-30 Highly stable noble metal nanoparticles dispersible in biocompatible solvents: synthesis of cationic phosphonium gold nanoparticles in water and DMSO b219fdfea246d96dfc9c4eecfd60f2a6 0000-0003-2972-8073 Yon Ju-Nam Yon Ju-Nam true false 4c1c9800dffa623353dff0ab1271be64 0000-0002-2046-1010 Jesus Ojeda Ledo Jesus Ojeda Ledo true false 2015-10-30 CHEG In this work, we report the synthesis of novel cationic phosphonium gold nanoparticles dispersible in water and dimethyl sulfoxide (DMSO) for their potential use in biomedical applications. All the cationic-functionalising ligands currently reported in the literature are ammonium-based species. Here, the synthesis and characterisation of an alternative system, based on phosphonioalkylthiosulfate zwitterions and phosphonioalkylthioacetate were carried out. We have also demonstrated that our phosphonioalkylthiosulfate zwitterions readily disproportionate into phosphonioalkylthiolates in situ during the synthesis of gold nanoparticles produced by the borohydride reduction of gold(III) salts. The synthesis of the cationic gold nanoparticles using these phosphonium ligands was carried out in water and DMSO. UV-visible spectroscopic and TEM studies have shown that the phosphonioalkylthiolates bind to the surface of gold nanoparticles which are typically around 10 nm in diameter. The resulting cationic-functionalised gold nanoparticles are dispersible in aqueous media and in DMSO, which is the only organic solvent approved by the U.S. Food and Drug Administration (FDA) for drug carrier tests. This indicates their potential future use in biological applications. This work shows the synthesis of a new family of phosphonium-based ligands, which behave as cationic masked thiolate ligands in the functionalisation of gold nanoparticles. These highly stable colloidal cationic phosphonium gold nanoparticles dispersed in water and DMSO can offer a great opportunity for the design of novel biorecognition and drug delivery systems. Journal Article Faraday Discussions 186 77 93 1359-6640 1364-5498 phosphonioalkylthiosulfate, phosphoniumalkylthioacetate, cationic phosphonium gold nanoparticles, DMSO 15 4 2016 2016-04-15 10.1039/C5FD00131E COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University 2020-05-22T13:55:57.7550932 2015-10-30T15:34:44.1195260 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Yon Ju-Nam 0000-0003-2972-8073 1 Jesus Ojeda Ledo 0000-0002-2046-1010 2 0024082-02032016230819.pdf FDpaper.pdf 2016-03-02T23:08:19.9300000 Output 756269 application/pdf Accepted Manuscript true 2016-10-30T00:00:00.0000000 true
title Highly stable noble metal nanoparticles dispersible in biocompatible solvents: synthesis of cationic phosphonium gold nanoparticles in water and DMSO
spellingShingle Highly stable noble metal nanoparticles dispersible in biocompatible solvents: synthesis of cationic phosphonium gold nanoparticles in water and DMSO
Yon Ju-Nam
Jesus Ojeda Ledo
title_short Highly stable noble metal nanoparticles dispersible in biocompatible solvents: synthesis of cationic phosphonium gold nanoparticles in water and DMSO
title_full Highly stable noble metal nanoparticles dispersible in biocompatible solvents: synthesis of cationic phosphonium gold nanoparticles in water and DMSO
title_fullStr Highly stable noble metal nanoparticles dispersible in biocompatible solvents: synthesis of cationic phosphonium gold nanoparticles in water and DMSO
title_full_unstemmed Highly stable noble metal nanoparticles dispersible in biocompatible solvents: synthesis of cationic phosphonium gold nanoparticles in water and DMSO
title_sort Highly stable noble metal nanoparticles dispersible in biocompatible solvents: synthesis of cationic phosphonium gold nanoparticles in water and DMSO
author_id_str_mv b219fdfea246d96dfc9c4eecfd60f2a6
4c1c9800dffa623353dff0ab1271be64
author_id_fullname_str_mv b219fdfea246d96dfc9c4eecfd60f2a6_***_Yon Ju-Nam
4c1c9800dffa623353dff0ab1271be64_***_Jesus Ojeda Ledo
author Yon Ju-Nam
Jesus Ojeda Ledo
author2 Yon Ju-Nam
Jesus Ojeda Ledo
format Journal article
container_title Faraday Discussions
container_volume 186
container_start_page 77
publishDate 2016
institution Swansea University
issn 1359-6640
1364-5498
doi_str_mv 10.1039/C5FD00131E
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 1
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description In this work, we report the synthesis of novel cationic phosphonium gold nanoparticles dispersible in water and dimethyl sulfoxide (DMSO) for their potential use in biomedical applications. All the cationic-functionalising ligands currently reported in the literature are ammonium-based species. Here, the synthesis and characterisation of an alternative system, based on phosphonioalkylthiosulfate zwitterions and phosphonioalkylthioacetate were carried out. We have also demonstrated that our phosphonioalkylthiosulfate zwitterions readily disproportionate into phosphonioalkylthiolates in situ during the synthesis of gold nanoparticles produced by the borohydride reduction of gold(III) salts. The synthesis of the cationic gold nanoparticles using these phosphonium ligands was carried out in water and DMSO. UV-visible spectroscopic and TEM studies have shown that the phosphonioalkylthiolates bind to the surface of gold nanoparticles which are typically around 10 nm in diameter. The resulting cationic-functionalised gold nanoparticles are dispersible in aqueous media and in DMSO, which is the only organic solvent approved by the U.S. Food and Drug Administration (FDA) for drug carrier tests. This indicates their potential future use in biological applications. This work shows the synthesis of a new family of phosphonium-based ligands, which behave as cationic masked thiolate ligands in the functionalisation of gold nanoparticles. These highly stable colloidal cationic phosphonium gold nanoparticles dispersed in water and DMSO can offer a great opportunity for the design of novel biorecognition and drug delivery systems.
published_date 2016-04-15T03:28:31Z
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