Journal article 1421 views
3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications
Lydia Powell ,
Adam Rees,
Lydia C. Powell,
Gary Chinga-Carrasco,
David Gethin ,
Kristin Syverud,
Katja E. Hill,
David W. Thomas
BioMed Research International, Volume: 2015, Pages: 1 - 7
Swansea University Authors: Lydia Powell , David Gethin
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DOI (Published version): 10.1155/2015/925757
Abstract
Nanocellulose has a variety of advantages, which make the material most suitable for use in biomedical devices such as wound dressings. The material is strong, allows for production of transparent films, provides a moist wound healing environment, and can form elastic gels with bioresponsive charact...
Published in: | BioMed Research International |
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ISSN: | 2314-6133 |
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2015
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URI: | https://cronfa.swan.ac.uk/Record/cronfa22361 |
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2019-09-27T15:42:16.0549925 v2 22361 2015-07-16 3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications 0e7e702952672bcbfdfd4974199202fb 0000-0002-8641-0160 Lydia Powell Lydia Powell true false 20b93675a5457203ae87ebc32bd6d155 0000-0002-7142-8253 David Gethin David Gethin true false 2015-07-16 BMS Nanocellulose has a variety of advantages, which make the material most suitable for use in biomedical devices such as wound dressings. The material is strong, allows for production of transparent films, provides a moist wound healing environment, and can form elastic gels with bioresponsive characteristics. In this study, we explore the application of nanocellulose as a bioink for modifying film surfaces by a bioprinting process. Two different nanocelluloses were used, prepared with TEMPO mediated oxidation and a combination of carboxymethylation and periodate oxidation. The combination of carboxymethylation and periodate oxidation produced a homogeneous material with short nanofibrils, having widths <20 nm and lengths <200 nm. The small dimensions of the nanofibrils reduced the viscosity of the nanocellulose, thus yielding a material with good rheological properties for use as a bioink. The nanocellulose bioink was thus used for printing 3D porous structures, which is exemplified in this study. We also demonstrated that both nanocelluloses did not support bacterial growth, which is an interesting property of these novel materials. Journal Article BioMed Research International 2015 1 7 2314-6133 31 12 2015 2015-12-31 10.1155/2015/925757 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2019-09-27T15:42:16.0549925 2015-07-16T13:21:50.2254178 Lydia Powell 0000-0002-8641-0160 1 Adam Rees 2 Lydia C. Powell 3 Gary Chinga-Carrasco 4 David Gethin 0000-0002-7142-8253 5 Kristin Syverud 6 Katja E. Hill 7 David W. Thomas 8 |
title |
3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications |
spellingShingle |
3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications Lydia Powell David Gethin |
title_short |
3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications |
title_full |
3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications |
title_fullStr |
3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications |
title_full_unstemmed |
3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications |
title_sort |
3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications |
author_id_str_mv |
0e7e702952672bcbfdfd4974199202fb 20b93675a5457203ae87ebc32bd6d155 |
author_id_fullname_str_mv |
0e7e702952672bcbfdfd4974199202fb_***_Lydia Powell 20b93675a5457203ae87ebc32bd6d155_***_David Gethin |
author |
Lydia Powell David Gethin |
author2 |
Lydia Powell Adam Rees Lydia C. Powell Gary Chinga-Carrasco David Gethin Kristin Syverud Katja E. Hill David W. Thomas |
format |
Journal article |
container_title |
BioMed Research International |
container_volume |
2015 |
container_start_page |
1 |
publishDate |
2015 |
institution |
Swansea University |
issn |
2314-6133 |
doi_str_mv |
10.1155/2015/925757 |
document_store_str |
0 |
active_str |
0 |
description |
Nanocellulose has a variety of advantages, which make the material most suitable for use in biomedical devices such as wound dressings. The material is strong, allows for production of transparent films, provides a moist wound healing environment, and can form elastic gels with bioresponsive characteristics. In this study, we explore the application of nanocellulose as a bioink for modifying film surfaces by a bioprinting process. Two different nanocelluloses were used, prepared with TEMPO mediated oxidation and a combination of carboxymethylation and periodate oxidation. The combination of carboxymethylation and periodate oxidation produced a homogeneous material with short nanofibrils, having widths <20 nm and lengths <200 nm. The small dimensions of the nanofibrils reduced the viscosity of the nanocellulose, thus yielding a material with good rheological properties for use as a bioink. The nanocellulose bioink was thus used for printing 3D porous structures, which is exemplified in this study. We also demonstrated that both nanocelluloses did not support bacterial growth, which is an interesting property of these novel materials. |
published_date |
2015-12-31T03:26:37Z |
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1763750967002529792 |
score |
11.037603 |