Journal article 491 views
Genome-wide association of functional traits linked with Campylobacter jejuni survival from farm to fork
Koji Yahara,
Guillaume Méric,
Aidan J. Taylor,
Stefan P. W. de Vries,
Susan Murray,
Ben Pascoe 
,
Leonardos Mageiros,
Alicia Torralbo,
Ana Vidal,
Anne Ridley,
Sho Komukai,
Helen Wimalarathna,
Alison J. Cody,
Frances M. Colles,
Noel McCarthy,
David Harris,
James E. Bray,
Keith A. Jolley,
Martin C. J. Maiden,
Stephen D. Bentley,
Julian Parkhill,
Christopher D. Bayliss,
Andrew Grant,
Duncan Maskell,
Xavier Didelot,
David J. Kelly,
Samuel K. Sheppard
,
Leonardos Mageiros,
Alicia Torralbo,
Ana Vidal,
Anne Ridley,
Sho Komukai,
Helen Wimalarathna,
Alison J. Cody,
Frances M. Colles,
Noel McCarthy,
David Harris,
James E. Bray,
Keith A. Jolley,
Martin C. J. Maiden,
Stephen D. Bentley,
Julian Parkhill,
Christopher D. Bayliss,
Andrew Grant,
Duncan Maskell,
Xavier Didelot,
David J. Kelly,
Samuel K. Sheppard
Environmental Microbiology, Volume: 19, Issue: 1, Pages: 361 - 380
Swansea University Author:
Ben Pascoe
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1111/1462-2920.13628
Abstract
Campylobacter jejuni is a major cause of bacterial gastroenteritis worldwide, primarily associated with the consumption of contaminated poultry. C. jejuni lineages vary in host range and prevalence in human infection, suggesting differences in survival throughout the poultry processing chain. From 7...
| Published in: | Environmental Microbiology |
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| ISSN: | 14622912 |
| Published: |
2017
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa22346 |
| Abstract: |
Campylobacter jejuni is a major cause of bacterial gastroenteritis worldwide, primarily associated with the consumption of contaminated poultry. C. jejuni lineages vary in host range and prevalence in human infection, suggesting differences in survival throughout the poultry processing chain. From 7,343 MLST-characterised isolates, we sequenced 600 C. jejuni and C. coli isolates from various stages of poultry processing and clinical cases. A genome-wide association study (GWAS) in C. jejuni ST-21 and ST-45 complexes identified genetic elements over-represented in clinical isolates that increased in frequency throughout the poultry processing chain. Disease-associated SNPs were distinct in these complexes, sometimes organised in haplotype blocks. The function of genes containing associated elements was investigated, demonstrating roles for cj1377c in formate metabolism, nuoK in aerobic survival and oxidative respiration, and cj1368-70 in nucleotide salvage. This work demonstrates the utility of GWAS for investigating transmission in natural zoonotic pathogen populations and provides evidence that major C. jejuni lineages have distinct genotypes associated with survival, within the host specific niche, from farm to fork. |
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| Keywords: |
genome-wide association study, GWAS, population structure, population genomics, food chain, Campylobacter, zoonosis, industrial food safety |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
1 |
| Start Page: |
361 |
| End Page: |
380 |