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A multi-scale computational assessment of channel gating assumptions within the Meissner corpuscle

D.D. Somer, Djordje Peric Orcid Logo, Eduardo De Souza Neto Orcid Logo, Wulf Dettmer Orcid Logo

Journal of Biomechanics, Volume: 48, Issue: 1, Pages: 73 - 80

Swansea University Authors: Djordje Peric Orcid Logo, Eduardo De Souza Neto Orcid Logo, Wulf Dettmer Orcid Logo

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DOI (Published version): 10.1016/j.jbiomech.2014.11.003

Abstract

From the macroscopic mechanical deformation of skin to the feeling of touch is a chain of complex events whereby information is converted from one form to another between different scales. An important link in this chain is receptor activation, which requires incorporation of microanatomical, cellul...

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Published in: Journal of Biomechanics
ISSN: 0021-9290
Published: 2015
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URI: https://cronfa.swan.ac.uk/Record/cronfa21453
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first_indexed 2015-05-17T02:02:55Z
last_indexed 2020-12-19T03:35:15Z
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spelling 2020-12-18T11:26:33.0705065 v2 21453 2015-05-16 A multi-scale computational assessment of channel gating assumptions within the Meissner corpuscle 9d35cb799b2542ad39140943a9a9da65 0000-0002-1112-301X Djordje Peric Djordje Peric true false 91568dee6643b7d350f0d5e8edb7b46a 0000-0002-9378-4590 Eduardo De Souza Neto Eduardo De Souza Neto true false 30bb53ad906e7160e947fa01c16abf55 0000-0003-0799-4645 Wulf Dettmer Wulf Dettmer true false 2015-05-16 CIVL From the macroscopic mechanical deformation of skin to the feeling of touch is a chain of complex events whereby information is converted from one form to another between different scales. An important link in this chain is receptor activation, which requires incorporation of microanatomical, cellular and ion channel transduction models. Of particular interest is the deformations at the axon membrane bi-layer, which are believed to be involved in mechanoelectrical signal transduction by activation of ion channels. We present a fully coupled multi-scale finite element analysis of the finger pad during tactile exploration, whereby the Meissner corpuscle, which is modeled as a single representative volume element (RVE) at the microscopic level, interacts with the macroscopic finger model. Maximum values of local stretching and compression occurring at the bi-layer are monitored for finger models with and without fingerprints, the presence of which generates a remarkable amplification of the signal. The contours of the surface being explored are well represented by the maximal peaks observed within the membrane. Journal Article Journal of Biomechanics 48 1 73 80 0021-9290 2 1 2015 2015-01-02 10.1016/j.jbiomech.2014.11.003 COLLEGE NANME Civil Engineering COLLEGE CODE CIVL Swansea University 2020-12-18T11:26:33.0705065 2015-05-16T08:31:32.2471258 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering D.D. Somer 1 Djordje Peric 0000-0002-1112-301X 2 Eduardo De Souza Neto 0000-0002-9378-4590 3 Wulf Dettmer 0000-0003-0799-4645 4
title A multi-scale computational assessment of channel gating assumptions within the Meissner corpuscle
spellingShingle A multi-scale computational assessment of channel gating assumptions within the Meissner corpuscle
Djordje Peric
Eduardo De Souza Neto
Wulf Dettmer
title_short A multi-scale computational assessment of channel gating assumptions within the Meissner corpuscle
title_full A multi-scale computational assessment of channel gating assumptions within the Meissner corpuscle
title_fullStr A multi-scale computational assessment of channel gating assumptions within the Meissner corpuscle
title_full_unstemmed A multi-scale computational assessment of channel gating assumptions within the Meissner corpuscle
title_sort A multi-scale computational assessment of channel gating assumptions within the Meissner corpuscle
author_id_str_mv 9d35cb799b2542ad39140943a9a9da65
91568dee6643b7d350f0d5e8edb7b46a
30bb53ad906e7160e947fa01c16abf55
author_id_fullname_str_mv 9d35cb799b2542ad39140943a9a9da65_***_Djordje Peric
91568dee6643b7d350f0d5e8edb7b46a_***_Eduardo De Souza Neto
30bb53ad906e7160e947fa01c16abf55_***_Wulf Dettmer
author Djordje Peric
Eduardo De Souza Neto
Wulf Dettmer
author2 D.D. Somer
Djordje Peric
Eduardo De Souza Neto
Wulf Dettmer
format Journal article
container_title Journal of Biomechanics
container_volume 48
container_issue 1
container_start_page 73
publishDate 2015
institution Swansea University
issn 0021-9290
doi_str_mv 10.1016/j.jbiomech.2014.11.003
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering
document_store_str 0
active_str 0
description From the macroscopic mechanical deformation of skin to the feeling of touch is a chain of complex events whereby information is converted from one form to another between different scales. An important link in this chain is receptor activation, which requires incorporation of microanatomical, cellular and ion channel transduction models. Of particular interest is the deformations at the axon membrane bi-layer, which are believed to be involved in mechanoelectrical signal transduction by activation of ion channels. We present a fully coupled multi-scale finite element analysis of the finger pad during tactile exploration, whereby the Meissner corpuscle, which is modeled as a single representative volume element (RVE) at the microscopic level, interacts with the macroscopic finger model. Maximum values of local stretching and compression occurring at the bi-layer are monitored for finger models with and without fingerprints, the presence of which generates a remarkable amplification of the signal. The contours of the surface being explored are well represented by the maximal peaks observed within the membrane.
published_date 2015-01-02T03:25:27Z
_version_ 1763750893354745856
score 11.037056

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