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Molecular structural mechanics model for the mechanical properties of microtubules

Jin Zhang, Chengyuan Wang Orcid Logo

Biomechanics and Modeling in Mechanobiology, Volume: 13, Issue: 6, Pages: 1175 - 1184

Swansea University Author: Chengyuan Wang Orcid Logo

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DOI (Published version): 10.1007/s10237-014-0564-x

Abstract

The aim of this paper was to develop a structural mechanics (SM) model for the microtubules (MTs) in cells. The technique enables one to study the configuration effect on the mechanical properties of MTs and enjoys greatly improved computational efficiency as compared with molecular dynamics simulat...

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Published in: Biomechanics and Modeling in Mechanobiology
ISSN: 1617-7959 1617-7940
Published: 2014
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URI: https://cronfa.swan.ac.uk/Record/cronfa21141
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first_indexed 2015-05-07T02:10:13Z
last_indexed 2020-12-19T03:34:49Z
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spelling 2020-12-18T10:15:29.0871599 v2 21141 2015-05-06 Molecular structural mechanics model for the mechanical properties of microtubules fdea93ab99f51d0b3921d3601876c1e5 0000-0002-1001-2537 Chengyuan Wang Chengyuan Wang true false 2015-05-06 MECH The aim of this paper was to develop a structural mechanics (SM) model for the microtubules (MTs) in cells. The technique enables one to study the configuration effect on the mechanical properties of MTs and enjoys greatly improved computational efficiency as compared with molecular dynamics simulations. The SM model shows that the Young’s modulus has nearly a constant value around 0.83 GPa, whereas the shear modulus, two orders of magnitude lower, varies considerably with the protofilament number NN and helix-start number SS . The dependence of the bending stiffness and persistence length on the MT length and protofilament number NN is also examined and explained based on the continuum mechanics theories. Specifically, the SM model is found to be in good agreement with available simulation and experiment results, showing its robustness in studying the static deformation of MTs and the potential for characterizing the buckling and vibration of MTs as well as the mechanical behaviour of intermediate and actin filaments. Journal Article Biomechanics and Modeling in Mechanobiology 13 6 1175 1184 1617-7959 1617-7940 30 11 2014 2014-11-30 10.1007/s10237-014-0564-x COLLEGE NANME Mechanical Engineering COLLEGE CODE MECH Swansea University 2020-12-18T10:15:29.0871599 2015-05-06T17:36:03.8394124 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering Jin Zhang 1 Chengyuan Wang 0000-0002-1001-2537 2
title Molecular structural mechanics model for the mechanical properties of microtubules
spellingShingle Molecular structural mechanics model for the mechanical properties of microtubules
Chengyuan Wang
title_short Molecular structural mechanics model for the mechanical properties of microtubules
title_full Molecular structural mechanics model for the mechanical properties of microtubules
title_fullStr Molecular structural mechanics model for the mechanical properties of microtubules
title_full_unstemmed Molecular structural mechanics model for the mechanical properties of microtubules
title_sort Molecular structural mechanics model for the mechanical properties of microtubules
author_id_str_mv fdea93ab99f51d0b3921d3601876c1e5
author_id_fullname_str_mv fdea93ab99f51d0b3921d3601876c1e5_***_Chengyuan Wang
author Chengyuan Wang
author2 Jin Zhang
Chengyuan Wang
format Journal article
container_title Biomechanics and Modeling in Mechanobiology
container_volume 13
container_issue 6
container_start_page 1175
publishDate 2014
institution Swansea University
issn 1617-7959
1617-7940
doi_str_mv 10.1007/s10237-014-0564-x
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering
document_store_str 0
active_str 0
description The aim of this paper was to develop a structural mechanics (SM) model for the microtubules (MTs) in cells. The technique enables one to study the configuration effect on the mechanical properties of MTs and enjoys greatly improved computational efficiency as compared with molecular dynamics simulations. The SM model shows that the Young’s modulus has nearly a constant value around 0.83 GPa, whereas the shear modulus, two orders of magnitude lower, varies considerably with the protofilament number NN and helix-start number SS . The dependence of the bending stiffness and persistence length on the MT length and protofilament number NN is also examined and explained based on the continuum mechanics theories. Specifically, the SM model is found to be in good agreement with available simulation and experiment results, showing its robustness in studying the static deformation of MTs and the potential for characterizing the buckling and vibration of MTs as well as the mechanical behaviour of intermediate and actin filaments.
published_date 2014-11-30T03:25:01Z
_version_ 1763750866565726208
score 11.037056

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