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The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation

Brianne A. Kent, Amy L. Beynon, Amanda K.E. Hornsby, Pedro Bekinschtein, Timothy J. Bussey, Jeffrey Davies Orcid Logo, Lisa M. Saksida

Psychoneuroendocrinology, Volume: 51, Pages: 431 - 439

Swansea University Author: Jeffrey Davies Orcid Logo

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DOI (Published version): 10.1016/j.psyneuen.2014.10.015

Abstract

An important link exists between intact metabolic processes and normal cognitive functioning; however, the underlying mechanisms remain unknown. There is accumulating evidence that the gut hormone ghrelin, an orexigenic peptide that is elevated during calorie restriction (CR) and known primarily for...

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Published in: Psychoneuroendocrinology
Published: 2014
Online Access: http://www.sciencedirect.com/science/article/pii/S0306453014003990
URI: https://cronfa.swan.ac.uk/Record/cronfa19690
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first_indexed 2014-12-04T02:57:42Z
last_indexed 2018-07-20T12:55:40Z
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2018-07-20T11:32:49.4139503</datestamp><bib-version>v2</bib-version><id>19690</id><entry>2014-12-03</entry><title>The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation</title><swanseaauthors><author><sid>2cb3d1d96a7870a84d2f758e865172e6</sid><ORCID>0000-0002-4234-0033</ORCID><firstname>Jeffrey</firstname><surname>Davies</surname><name>Jeffrey Davies</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2014-12-03</date><deptcode>BMS</deptcode><abstract>An important link exists between intact metabolic processes and normal cognitive functioning; however, the underlying mechanisms remain unknown. There is accumulating evidence that the gut hormone ghrelin, an orexigenic peptide that is elevated during calorie restriction (CR) and known primarily for stimulating growth hormone release, has important extra-hypothalamic functions, such as enhancing synaptic plasticity and hippocampal neurogenesis. The present study was designed to evaluate the long-term effects of elevating acyl-ghrelin levels, albeit within the physiological range, on the number of new adult born neurons in the dentate gyrus (DG) and performance on the Spontaneous Location Recognition (SLR) task, previously shown to be DG-dependent and sensitive to manipulations of plasticity mechanisms and cell proliferation. The results revealed that peripheral treatment of rats with acyl-ghrelin enhanced both adult hippocampal neurogenesis and performance on SLR when measured 8&#x2013;10 days after the end of acyl-ghrelin treatment. Our data show that systemic administration of physiological levels of acyl-ghrelin can produce long-lasting improvements in spatial memory that persist following the end of treatment. As ghrelin is potentially involved in regulating the relationship between metabolic and cognitive dysfunction in ageing and neurodegenerative disease, elucidating the underlying mechanisms holds promise for identifying novel therapeutic targets and modifiable lifestyle factors that may have beneficial effects on the brain.</abstract><type>Journal Article</type><journal>Psychoneuroendocrinology</journal><volume>51</volume><paginationStart>431</paginationStart><paginationEnd>439</paginationEnd><publisher/><keywords>Adult hippocampal neurogenesis; Ghrelin; Pattern separation</keywords><publishedDay>23</publishedDay><publishedMonth>10</publishedMonth><publishedYear>2014</publishedYear><publishedDate>2014-10-23</publishedDate><doi>10.1016/j.psyneuen.2014.10.015</doi><url>http://www.sciencedirect.com/science/article/pii/S0306453014003990</url><notes></notes><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2018-07-20T11:32:49.4139503</lastEdited><Created>2014-12-03T20:07:03.2284950</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Brianne A.</firstname><surname>Kent</surname><order>1</order></author><author><firstname>Amy L.</firstname><surname>Beynon</surname><order>2</order></author><author><firstname>Amanda K.E.</firstname><surname>Hornsby</surname><order>3</order></author><author><firstname>Pedro</firstname><surname>Bekinschtein</surname><order>4</order></author><author><firstname>Timothy J.</firstname><surname>Bussey</surname><order>5</order></author><author><firstname>Jeffrey</firstname><surname>Davies</surname><orcid>0000-0002-4234-0033</orcid><order>6</order></author><author><firstname>Lisa M.</firstname><surname>Saksida</surname><order>7</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2018-07-20T11:32:49.4139503 v2 19690 2014-12-03 The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation 2cb3d1d96a7870a84d2f758e865172e6 0000-0002-4234-0033 Jeffrey Davies Jeffrey Davies true false 2014-12-03 BMS An important link exists between intact metabolic processes and normal cognitive functioning; however, the underlying mechanisms remain unknown. There is accumulating evidence that the gut hormone ghrelin, an orexigenic peptide that is elevated during calorie restriction (CR) and known primarily for stimulating growth hormone release, has important extra-hypothalamic functions, such as enhancing synaptic plasticity and hippocampal neurogenesis. The present study was designed to evaluate the long-term effects of elevating acyl-ghrelin levels, albeit within the physiological range, on the number of new adult born neurons in the dentate gyrus (DG) and performance on the Spontaneous Location Recognition (SLR) task, previously shown to be DG-dependent and sensitive to manipulations of plasticity mechanisms and cell proliferation. The results revealed that peripheral treatment of rats with acyl-ghrelin enhanced both adult hippocampal neurogenesis and performance on SLR when measured 8–10 days after the end of acyl-ghrelin treatment. Our data show that systemic administration of physiological levels of acyl-ghrelin can produce long-lasting improvements in spatial memory that persist following the end of treatment. As ghrelin is potentially involved in regulating the relationship between metabolic and cognitive dysfunction in ageing and neurodegenerative disease, elucidating the underlying mechanisms holds promise for identifying novel therapeutic targets and modifiable lifestyle factors that may have beneficial effects on the brain. Journal Article Psychoneuroendocrinology 51 431 439 Adult hippocampal neurogenesis; Ghrelin; Pattern separation 23 10 2014 2014-10-23 10.1016/j.psyneuen.2014.10.015 http://www.sciencedirect.com/science/article/pii/S0306453014003990 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2018-07-20T11:32:49.4139503 2014-12-03T20:07:03.2284950 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Brianne A. Kent 1 Amy L. Beynon 2 Amanda K.E. Hornsby 3 Pedro Bekinschtein 4 Timothy J. Bussey 5 Jeffrey Davies 0000-0002-4234-0033 6 Lisa M. Saksida 7
title The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
spellingShingle The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
Jeffrey Davies
title_short The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
title_full The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
title_fullStr The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
title_full_unstemmed The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
title_sort The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
author_id_str_mv 2cb3d1d96a7870a84d2f758e865172e6
author_id_fullname_str_mv 2cb3d1d96a7870a84d2f758e865172e6_***_Jeffrey Davies
author Jeffrey Davies
author2 Brianne A. Kent
Amy L. Beynon
Amanda K.E. Hornsby
Pedro Bekinschtein
Timothy J. Bussey
Jeffrey Davies
Lisa M. Saksida
format Journal article
container_title Psychoneuroendocrinology
container_volume 51
container_start_page 431
publishDate 2014
institution Swansea University
doi_str_mv 10.1016/j.psyneuen.2014.10.015
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://www.sciencedirect.com/science/article/pii/S0306453014003990
document_store_str 0
active_str 0
description An important link exists between intact metabolic processes and normal cognitive functioning; however, the underlying mechanisms remain unknown. There is accumulating evidence that the gut hormone ghrelin, an orexigenic peptide that is elevated during calorie restriction (CR) and known primarily for stimulating growth hormone release, has important extra-hypothalamic functions, such as enhancing synaptic plasticity and hippocampal neurogenesis. The present study was designed to evaluate the long-term effects of elevating acyl-ghrelin levels, albeit within the physiological range, on the number of new adult born neurons in the dentate gyrus (DG) and performance on the Spontaneous Location Recognition (SLR) task, previously shown to be DG-dependent and sensitive to manipulations of plasticity mechanisms and cell proliferation. The results revealed that peripheral treatment of rats with acyl-ghrelin enhanced both adult hippocampal neurogenesis and performance on SLR when measured 8–10 days after the end of acyl-ghrelin treatment. Our data show that systemic administration of physiological levels of acyl-ghrelin can produce long-lasting improvements in spatial memory that persist following the end of treatment. As ghrelin is potentially involved in regulating the relationship between metabolic and cognitive dysfunction in ageing and neurodegenerative disease, elucidating the underlying mechanisms holds promise for identifying novel therapeutic targets and modifiable lifestyle factors that may have beneficial effects on the brain.
published_date 2014-10-23T03:23:11Z
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score 11.013619

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