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Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice

Xuefei Cao, Roberta A. Mittelstaedt, Mason G. Pearce, Bruce C. Allen, Lya G. Soeteman-Hernández, George Johnson Orcid Logo, C. Anita H. Bigger, Robert H. Heflich

Environmental and Molecular Mutagenesis, Pages: n/a - n/a

Swansea University Author: George Johnson Orcid Logo

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DOI (Published version): 10.1002/em.21854

Published in: Environmental and Molecular Mutagenesis
Published: 2014
Online Access: http://onlinelibrary.wiley.com/doi/10.1002/em.21854/abstract
URI: https://cronfa.swan.ac.uk/Record/cronfa17347
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first_indexed 2014-02-19T02:30:04Z
last_indexed 2019-08-28T19:32:57Z
id cronfa17347
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spelling 2019-08-28T14:44:21.1230403 v2 17347 2014-02-18 Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice 37d0f121db69fd09f364df89e4405e31 0000-0001-5643-9942 George Johnson George Johnson true false 2014-02-18 BMS Journal Article Environmental and Molecular Mutagenesis n/a n/a 1 5 2014 2014-05-01 10.1002/em.21854 http://onlinelibrary.wiley.com/doi/10.1002/em.21854/abstract The paper has been selected for Editors Choice. http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2280/homepage/editor_s_choice.htm. This is a high accolade and an official letter was sent from EMM to senior US-FDA-NCTR staff including Director William (Bill) Slikker stating the importance of this paper to human health risk assessment. It is of high impact and follows on from the story of Roche's EMS impurity in Viracept, showing that the threshold dose and safe human dose (PDE) is reduced when a different system is used. COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2019-08-28T14:44:21.1230403 2014-02-18T14:57:03.8080335 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Xuefei Cao 1 Roberta A. Mittelstaedt 2 Mason G. Pearce 3 Bruce C. Allen 4 Lya G. Soeteman-Hernández 5 George Johnson 0000-0001-5643-9942 6 C. Anita H. Bigger 7 Robert H. Heflich 8
title Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice
spellingShingle Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice
George Johnson
title_short Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice
title_full Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice
title_fullStr Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice
title_full_unstemmed Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice
title_sort Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice
author_id_str_mv 37d0f121db69fd09f364df89e4405e31
author_id_fullname_str_mv 37d0f121db69fd09f364df89e4405e31_***_George Johnson
author George Johnson
author2 Xuefei Cao
Roberta A. Mittelstaedt
Mason G. Pearce
Bruce C. Allen
Lya G. Soeteman-Hernández
George Johnson
C. Anita H. Bigger
Robert H. Heflich
format Journal article
container_title Environmental and Molecular Mutagenesis
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publishDate 2014
institution Swansea University
doi_str_mv 10.1002/em.21854
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://onlinelibrary.wiley.com/doi/10.1002/em.21854/abstract
document_store_str 0
active_str 0
published_date 2014-05-01T03:20:01Z
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