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Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia

Sarah Bate, Sarah J Cook, Bradley Duchaine, Jeremy Tree Orcid Logo, Edwin J Burns, Timothy L Hodgson

Cortex, Volume: 50, Pages: 55 - 63

Swansea University Author: Jeremy Tree Orcid Logo

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DOI (Published version): 10.1016/j.cortex.2013.08.006

Abstract

Developmental prosopagnosia (DP) is characterised by a severe lifelong impairment in face recognition. In recent years it has become clear that DP affects a substantial number of people, yet little work has attempted to improve face processing in these individuals. Intriguingly, recent evidence sugg...

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Published in: Cortex
Published: 2014
URI: https://cronfa.swan.ac.uk/Record/cronfa16861
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first_indexed 2014-01-30T17:01:13Z
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spelling 2020-09-09T08:46:00.8847285 v2 16861 2014-01-10 Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia 373fd575114a743d502a979c6161b1ad 0000-0001-6000-8125 Jeremy Tree Jeremy Tree true false 2014-01-10 HPS Developmental prosopagnosia (DP) is characterised by a severe lifelong impairment in face recognition. In recent years it has become clear that DP affects a substantial number of people, yet little work has attempted to improve face processing in these individuals. Intriguingly, recent evidence suggests that intranasal inhalation of the hormone oxytocin can improve face processing in unimpaired participants, and we investigated whether similar findings might be noted in DP. Ten adults with DP and 10 matched controls were tested using a randomized placebo-controlled double-blind within-subject experimental design (AB-BA). Each participant took part in two testing sessions separated by a 14–25 day interval. In each session, participants inhaled 24 IU of oxytocin or placebo spray, followed by a 45 min resting period to allow central oxytocin levels to plateau. Participants then completed two face processing tests: one assessing memory for a set of newly encoded faces, and one measuring the ability to match simultaneously presented faces according to identity. Participants completed the Multidimensional Mood Questionnaire (MMQ) at three points in each testing session to assess the possible mood-altering effects of oxytocin and to control for attention and wakefulness. Statistical comparisons revealed an improvement for DP but not control participants on both tests in the oxytocin condition, and analysis of scores on the MMQ indicated that the effect cannot be attributed to changes in mood, attention or wakefulness. This investigation provides the first evidence that oxytocin can improve face processing in DP, and the potential neural underpinnings of the findings are discussed alongside their implications for the treatment of face processing disorders. Journal Article Cortex 50 55 63 1 1 2014 2014-01-01 10.1016/j.cortex.2013.08.006 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University 2020-09-09T08:46:00.8847285 2014-01-10T16:11:48.7306465 Faculty of Medicine, Health and Life Sciences School of Psychology Sarah Bate 1 Sarah J Cook 2 Bradley Duchaine 3 Jeremy Tree 0000-0001-6000-8125 4 Edwin J Burns 5 Timothy L Hodgson 6
title Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
spellingShingle Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
Jeremy Tree
title_short Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
title_full Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
title_fullStr Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
title_full_unstemmed Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
title_sort Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
author_id_str_mv 373fd575114a743d502a979c6161b1ad
author_id_fullname_str_mv 373fd575114a743d502a979c6161b1ad_***_Jeremy Tree
author Jeremy Tree
author2 Sarah Bate
Sarah J Cook
Bradley Duchaine
Jeremy Tree
Edwin J Burns
Timothy L Hodgson
format Journal article
container_title Cortex
container_volume 50
container_start_page 55
publishDate 2014
institution Swansea University
doi_str_mv 10.1016/j.cortex.2013.08.006
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 0
active_str 0
description Developmental prosopagnosia (DP) is characterised by a severe lifelong impairment in face recognition. In recent years it has become clear that DP affects a substantial number of people, yet little work has attempted to improve face processing in these individuals. Intriguingly, recent evidence suggests that intranasal inhalation of the hormone oxytocin can improve face processing in unimpaired participants, and we investigated whether similar findings might be noted in DP. Ten adults with DP and 10 matched controls were tested using a randomized placebo-controlled double-blind within-subject experimental design (AB-BA). Each participant took part in two testing sessions separated by a 14–25 day interval. In each session, participants inhaled 24 IU of oxytocin or placebo spray, followed by a 45 min resting period to allow central oxytocin levels to plateau. Participants then completed two face processing tests: one assessing memory for a set of newly encoded faces, and one measuring the ability to match simultaneously presented faces according to identity. Participants completed the Multidimensional Mood Questionnaire (MMQ) at three points in each testing session to assess the possible mood-altering effects of oxytocin and to control for attention and wakefulness. Statistical comparisons revealed an improvement for DP but not control participants on both tests in the oxytocin condition, and analysis of scores on the MMQ indicated that the effect cannot be attributed to changes in mood, attention or wakefulness. This investigation provides the first evidence that oxytocin can improve face processing in DP, and the potential neural underpinnings of the findings are discussed alongside their implications for the treatment of face processing disorders.
published_date 2014-01-01T03:19:21Z
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score 11.037603

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