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Islands of Conformational Stability for Filopodia

Matthew S Turner, Rob Daniels Orcid Logo

PLoS ONE, Volume: 8, Issue: 3, Start page: e59010

Swansea University Author: Rob Daniels Orcid Logo

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DOI (Published version): 10.1371/journal.pone.0059010

Abstract

Filopodia are long, thin protrusions formed when bundles of fibers grow outwardly from a cell surface while remaining closed in a membrane tube. We study the subtle issue of the mechanical stability of such filopodia and how this depends on the deformation of the membrane that arises when the fiber...

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Published in: PLoS ONE
ISSN: 1932-6203
Published: 2013
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URI: https://cronfa.swan.ac.uk/Record/cronfa15738
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first_indexed 2013-09-06T01:58:28Z
last_indexed 2021-03-18T03:28:59Z
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spelling 2021-03-17T09:48:02.7306973 v2 15738 2013-09-05 Islands of Conformational Stability for Filopodia 23f38c3bb732d4378986bdfaf7b6ee51 0000-0002-6933-8144 Rob Daniels Rob Daniels true false 2013-09-05 MEDE Filopodia are long, thin protrusions formed when bundles of fibers grow outwardly from a cell surface while remaining closed in a membrane tube. We study the subtle issue of the mechanical stability of such filopodia and how this depends on the deformation of the membrane that arises when the fiber bundle adopts a helical configuration. We calculate the ground state conformation of such filopodia, taking into account the steric interaction between the membrane and the enclosed semiflexible fiber bundle. For typical filopodia we find that a minimum number of fibers is required for filopodium stability. Our calculation elucidates how experimentally observed filopodia can obviate the classical Euler buckling condition and remain stable up to several tens of microns. We briefly discuss how experimental observation of the results obtained in this work for the helical-like deformations of enclosing membrane tubes in filopodia could possibly be observed in the acrosomal reactions of the sea cucumber Thyone, and the horseshoe crab Limulus. Any realistic future theories for filopodium stability are likely to rely on an accurate treatment of such steric effects, as analysed in this work.Impact Factor: 3.730 Journal Article PLoS ONE 8 3 e59010 1932-6203 31 12 2013 2013-12-31 10.1371/journal.pone.0059010 Filopodia are fundamental to cellular life, and their crucial biological function depends on their being able to adopt extended shapes, or conformations. This work is important in that it provides the first analytical treatment of the stability of such filopdoia, with direct significance and relevance therefore for further applications in biology, physiology, and medicine. We also make explicit theoretical predicitions for the stability of filopdoia which should be of vital interest to, and testable by, awaiting experimental co-workers in this field. COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2021-03-17T09:48:02.7306973 2013-09-05T11:36:24.8598957 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Matthew S Turner 1 Rob Daniels 0000-0002-6933-8144 2
title Islands of Conformational Stability for Filopodia
spellingShingle Islands of Conformational Stability for Filopodia
Rob Daniels
title_short Islands of Conformational Stability for Filopodia
title_full Islands of Conformational Stability for Filopodia
title_fullStr Islands of Conformational Stability for Filopodia
title_full_unstemmed Islands of Conformational Stability for Filopodia
title_sort Islands of Conformational Stability for Filopodia
author_id_str_mv 23f38c3bb732d4378986bdfaf7b6ee51
author_id_fullname_str_mv 23f38c3bb732d4378986bdfaf7b6ee51_***_Rob Daniels
author Rob Daniels
author2 Matthew S Turner
Rob Daniels
format Journal article
container_title PLoS ONE
container_volume 8
container_issue 3
container_start_page e59010
publishDate 2013
institution Swansea University
issn 1932-6203
doi_str_mv 10.1371/journal.pone.0059010
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
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description Filopodia are long, thin protrusions formed when bundles of fibers grow outwardly from a cell surface while remaining closed in a membrane tube. We study the subtle issue of the mechanical stability of such filopodia and how this depends on the deformation of the membrane that arises when the fiber bundle adopts a helical configuration. We calculate the ground state conformation of such filopodia, taking into account the steric interaction between the membrane and the enclosed semiflexible fiber bundle. For typical filopodia we find that a minimum number of fibers is required for filopodium stability. Our calculation elucidates how experimentally observed filopodia can obviate the classical Euler buckling condition and remain stable up to several tens of microns. We briefly discuss how experimental observation of the results obtained in this work for the helical-like deformations of enclosing membrane tubes in filopodia could possibly be observed in the acrosomal reactions of the sea cucumber Thyone, and the horseshoe crab Limulus. Any realistic future theories for filopodium stability are likely to rely on an accurate treatment of such steric effects, as analysed in this work.Impact Factor: 3.730
published_date 2013-12-31T03:17:54Z
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score 11.01409

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