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Relationship between changes in pulmonary V˙O2 kinetics and autonomic regulation of blood flow

Melitta McNarry Orcid Logo, M. I. C. Kingsley, Michael Lewis

Scandinavian Journal of Medicine & Science in Sports, Volume: 24, Issue: 4, Pages: 613 - 621

Swansea University Authors: Melitta McNarry Orcid Logo, Michael Lewis

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DOI (Published version): 10.1111/sms.12041

Abstract

Various regulatory mechanisms of pulmonary oxygen uptake () kinetics have been postulated. The purpose of this study was to investigate the relationship between vagal withdrawal, measured using RMSSDRR, the root mean square of successive differences in cardiac interval (RR) kinetics, a mediator of o...

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Published in: Scandinavian Journal of Medicine & Science in Sports
ISSN: 0905-7188
Published: Wiley 2014
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URI: https://cronfa.swan.ac.uk/Record/cronfa14731
first_indexed 2013-07-23T12:12:50Z
last_indexed 2020-07-07T18:27:10Z
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spelling 2020-07-07T15:22:28.3316322 v2 14731 2013-04-24 Relationship between changes in pulmonary V˙O2 kinetics and autonomic regulation of blood flow 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false b59c8f5c056bac7e6995385f22ad1639 Michael Lewis Michael Lewis true false 2013-04-24 EAAS Various regulatory mechanisms of pulmonary oxygen uptake () kinetics have been postulated. The purpose of this study was to investigate the relationship between vagal withdrawal, measured using RMSSDRR, the root mean square of successive differences in cardiac interval (RR) kinetics, a mediator of oxygen delivery, and kinetics. Forty-nine healthy adults (23 ± 3 years; 72 ± 13 kg; 1.80 ± 0.08 m) performed multiple repeat transitions to moderate- and heavy-intensity exercise. Electrocardiography, impedance cardiography, and pulmonary gas exchange parameters were measured throughout; time domain measures of heart rate variability were subsequently derived. The parameters describing the dynamic response of , cardiac output () and RMSSDRR were determined using a mono-exponential model. During heavy-intensity exercise, the phase II τ of was significantly correlated with the τ of RR (r = 0.36, P < 0.05), Q (r = 0.67, P < 0.05), and RMSSDRR (r = 0.38, P < 0.05). The τ describing the rise in Q explained 47% of the variation in τ, with 30% of the rate of this rise in Q explained by the τ of RR and RMSSDRR. No relationship was evident between kinetics and those of Q, RR, or RMSSDRR during moderate exercise. Vagal withdrawal kinetics support the concept of a centrally mediated oxygen delivery limitation partly regulating kinetics during heavy-, but not moderate-, intensity exercise. Journal Article Scandinavian Journal of Medicine & Science in Sports 24 4 613 621 Wiley 0905-7188 heart rate variability; kinetics;oxygen delivery;cardiac output 1 8 2014 2014-08-01 10.1111/sms.12041 http://dx.doi.org/10.1111/sms.12041 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2020-07-07T15:22:28.3316322 2013-04-24T14:16:52.8249589 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised Melitta McNarry 0000-0003-0813-7477 1 M. I. C. Kingsley 2 Michael Lewis 3 14731__7498__4e1c7b0cfa5a41b1a764072e351cfcaf.pdf 14731.pdf 2017-12-20T14:24:40.5100000 Output 1021020 application/pdf Accepted Manuscript true 2016-03-29T00:00:00.0000000 true eng
title Relationship between changes in pulmonary V˙O2 kinetics and autonomic regulation of blood flow
spellingShingle Relationship between changes in pulmonary V˙O2 kinetics and autonomic regulation of blood flow
Melitta McNarry
Michael Lewis
title_short Relationship between changes in pulmonary V˙O2 kinetics and autonomic regulation of blood flow
title_full Relationship between changes in pulmonary V˙O2 kinetics and autonomic regulation of blood flow
title_fullStr Relationship between changes in pulmonary V˙O2 kinetics and autonomic regulation of blood flow
title_full_unstemmed Relationship between changes in pulmonary V˙O2 kinetics and autonomic regulation of blood flow
title_sort Relationship between changes in pulmonary V˙O2 kinetics and autonomic regulation of blood flow
author_id_str_mv 062f5697ff59f004bc8c713955988398
b59c8f5c056bac7e6995385f22ad1639
author_id_fullname_str_mv 062f5697ff59f004bc8c713955988398_***_Melitta McNarry
b59c8f5c056bac7e6995385f22ad1639_***_Michael Lewis
author Melitta McNarry
Michael Lewis
author2 Melitta McNarry
M. I. C. Kingsley
Michael Lewis
format Journal article
container_title Scandinavian Journal of Medicine & Science in Sports
container_volume 24
container_issue 4
container_start_page 613
publishDate 2014
institution Swansea University
issn 0905-7188
doi_str_mv 10.1111/sms.12041
publisher Wiley
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
url http://dx.doi.org/10.1111/sms.12041
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description Various regulatory mechanisms of pulmonary oxygen uptake () kinetics have been postulated. The purpose of this study was to investigate the relationship between vagal withdrawal, measured using RMSSDRR, the root mean square of successive differences in cardiac interval (RR) kinetics, a mediator of oxygen delivery, and kinetics. Forty-nine healthy adults (23 ± 3 years; 72 ± 13 kg; 1.80 ± 0.08 m) performed multiple repeat transitions to moderate- and heavy-intensity exercise. Electrocardiography, impedance cardiography, and pulmonary gas exchange parameters were measured throughout; time domain measures of heart rate variability were subsequently derived. The parameters describing the dynamic response of , cardiac output () and RMSSDRR were determined using a mono-exponential model. During heavy-intensity exercise, the phase II τ of was significantly correlated with the τ of RR (r = 0.36, P < 0.05), Q (r = 0.67, P < 0.05), and RMSSDRR (r = 0.38, P < 0.05). The τ describing the rise in Q explained 47% of the variation in τ, with 30% of the rate of this rise in Q explained by the τ of RR and RMSSDRR. No relationship was evident between kinetics and those of Q, RR, or RMSSDRR during moderate exercise. Vagal withdrawal kinetics support the concept of a centrally mediated oxygen delivery limitation partly regulating kinetics during heavy-, but not moderate-, intensity exercise.
published_date 2014-08-01T18:27:13Z
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