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Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2

Claire Hull, Oliver Bader, Josie Parker, Michael Weig, Uwe Gross, Andrew Warrilow, Diane Kelly, Steven Kelly Orcid Logo

Antimicrobial Agents and Chemotherapy, Volume: 56, Issue: 12, Pages: 6417 - 6421

Swansea University Authors: Claire Hull, Josie Parker, Andrew Warrilow, Diane Kelly, Steven Kelly Orcid Logo

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DOI (Published version): 10.1128/aac.01145-12

Abstract

Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC 8 μg ml(-1)) were found to be erg2 mutants wherein Δ(8)-sterol intermediates comprised > 90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in Erg2; the corresponding resid...

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Published in: Antimicrobial Agents and Chemotherapy
ISSN: 0066-4804 1098-6596
Published: American Society for Microbiology 2012
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URI: https://cronfa.swan.ac.uk/Record/cronfa13028
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spelling 2021-10-29T09:53:11.3373618 v2 13028 2012-10-10 Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2 6c495cb489b67bc9bb3f746975c4ff19 Claire Hull Claire Hull true false e563ed4e1c7db8d1e131fb78a5f8d0d5 Josie Parker Josie Parker true false f066e233e8d0136c9f547b86fa43747f Andrew Warrilow Andrew Warrilow true false 5ccf81e5d5beedf32ef8d7c3d7ac6c8c Diane Kelly Diane Kelly true false b17cebaf09b4d737b9378a3581e3de93 0000-0001-7991-5040 Steven Kelly Steven Kelly true false 2012-10-10 PMSC Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC 8 μg ml(-1)) were found to be erg2 mutants wherein Δ(8)-sterol intermediates comprised > 90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in Erg2; the corresponding residue (Thr(119)) in Saccharomyces cerevisiae is essential for sterol Δ8-Δ7 isomerization. This constitutes the first report of C. glabrata harboring mutations in ERG2 and exhibiting reduced sensitivity to amphotericin B. Journal Article Antimicrobial Agents and Chemotherapy 56 12 6417 6421 American Society for Microbiology 0066-4804 1098-6596 1 12 2012 2012-12-01 10.1128/aac.01145-12 http://dx.doi.org/10.1128/aac.01145-12 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2021-10-29T09:53:11.3373618 2012-10-10T10:34:54.4642667 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Claire Hull 1 Oliver Bader 2 Josie Parker 3 Michael Weig 4 Uwe Gross 5 Andrew Warrilow 6 Diane Kelly 7 Steven Kelly 0000-0001-7991-5040 8
title Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2
spellingShingle Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2
Claire Hull
Josie Parker
Andrew Warrilow
Diane Kelly
Steven Kelly
title_short Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2
title_full Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2
title_fullStr Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2
title_full_unstemmed Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2
title_sort Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2
author_id_str_mv 6c495cb489b67bc9bb3f746975c4ff19
e563ed4e1c7db8d1e131fb78a5f8d0d5
f066e233e8d0136c9f547b86fa43747f
5ccf81e5d5beedf32ef8d7c3d7ac6c8c
b17cebaf09b4d737b9378a3581e3de93
author_id_fullname_str_mv 6c495cb489b67bc9bb3f746975c4ff19_***_Claire Hull
e563ed4e1c7db8d1e131fb78a5f8d0d5_***_Josie Parker
f066e233e8d0136c9f547b86fa43747f_***_Andrew Warrilow
5ccf81e5d5beedf32ef8d7c3d7ac6c8c_***_Diane Kelly
b17cebaf09b4d737b9378a3581e3de93_***_Steven Kelly
author Claire Hull
Josie Parker
Andrew Warrilow
Diane Kelly
Steven Kelly
author2 Claire Hull
Oliver Bader
Josie Parker
Michael Weig
Uwe Gross
Andrew Warrilow
Diane Kelly
Steven Kelly
format Journal article
container_title Antimicrobial Agents and Chemotherapy
container_volume 56
container_issue 12
container_start_page 6417
publishDate 2012
institution Swansea University
issn 0066-4804
1098-6596
doi_str_mv 10.1128/aac.01145-12
publisher American Society for Microbiology
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://dx.doi.org/10.1128/aac.01145-12
document_store_str 0
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description Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC 8 μg ml(-1)) were found to be erg2 mutants wherein Δ(8)-sterol intermediates comprised > 90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in Erg2; the corresponding residue (Thr(119)) in Saccharomyces cerevisiae is essential for sterol Δ8-Δ7 isomerization. This constitutes the first report of C. glabrata harboring mutations in ERG2 and exhibiting reduced sensitivity to amphotericin B.
published_date 2012-12-01T03:14:55Z
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