The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults

McNarry, M. A; C, M. I.; Lewis, M. J; Lewis, Michael; McNarry, Melitta

doi:10.1152/ajpregu.00203.2012

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The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults

M. A McNarry, M. I. C Kingsley, M. J Lewis, Michael Lewis, Melitta McNarry

AJP: Regulatory, Integrative and Comparative Physiology

Swansea University Authors: Michael Lewis, Melitta McNarry

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DOI (Published version): 10.1152/ajpregu.00203.2012

Abstract

It is unclear whether pulmonary oxygen uptake (VO2) kinetics demonstrate linear, first order behaviour during supra gas exchange threshold exercise. Resolution of this issue is pertinent to the elucidation of the factors regulating VO2 kinetics, with oxygen availability and utilisation proposed as p...

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Published in:	AJP: Regulatory, Integrative and Comparative Physiology
ISSN:	0363-6119 1522-1490
Published:	2012
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa12784
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spelling	2017-11-25T09:47:49.6324003 v2 12784 2012-09-24 The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults b59c8f5c056bac7e6995385f22ad1639 Michael Lewis Michael Lewis true false 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false 2012-09-24 FGSEN It is unclear whether pulmonary oxygen uptake (VO2) kinetics demonstrate linear, first order behaviour during supra gas exchange threshold exercise. Resolution of this issue is pertinent to the elucidation of the factors regulating VO2 kinetics, with oxygen availability and utilisation proposed as putative mediators. To re-examine this issue with the advantage of a relatively large sample size, fifty young (24±4 yrs) and fifteen late middle-aged (54±3 yrs) participants completed repeated bouts of moderate and heavy exercise. Pulmonary gas exchange, heart rate (HR) and cardiac output ("Q") variables were measured throughout. The phase II τ was slower during heavy exercise in both young (Mod: 22±9; Hvy: 29±9s; P≤0.001) and middle-aged (Mod: 22±9; Hvy: 30±8s; P≤0.001) individuals. The HR τ was slower during heavy exercise in young (Mod: 33±10; Hvy: 44±15s; P≤0.05) and middle-aged (Mod: 30±12; Hvy: 50±20s; P≤0.05) participants, and the "Q" τ showed a similar trend (Young - Mod: 21±13; Hvy: 28±16 s; Middle-aged - Mod: 32±13; Hvy: 40±15s; P≥0.05). There were no differences in primary component VO2 kinetics between age groups but the middle-aged group had a significantly reduced VO2 slow component amplitude in both absolute (Young: 0.25±0.09; Middle-aged: 0.11±0.06 l∙min-1; P≤0.05) and relative terms (Young: 15±10; Middle-aged: 9±4%; P≤0.05). Thus, VO2 kinetics do not demonstrate dynamic linearity during heavy intensity exercise. Speculatively, the slower phase II τ during heavy exercise might be attributable to reduced oxygen availability. Finally, the primary and slow components of VO2 kinetics appear to be differentially influenced by middle-age. Journal Article AJP: Regulatory, Integrative and Comparative Physiology 0363-6119 1522-1490 15 10 2012 2012-10-15 10.1152/ajpregu.00203.2012 COLLEGE NANME Science and Engineering - Faculty COLLEGE CODE FGSEN Swansea University 2017-11-25T09:47:49.6324003 2012-09-24T11:06:21.8515700 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised M. A McNarry 1 M. I. C Kingsley 2 M. J Lewis 3 Michael Lewis 4 Melitta McNarry 0000-0003-0813-7477 5
title	The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults
spellingShingle	The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults Michael Lewis Melitta McNarry
title_short	The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults
title_full	The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults
title_fullStr	The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults
title_full_unstemmed	The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults
title_sort	The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults
author_id_str_mv	b59c8f5c056bac7e6995385f22ad1639 062f5697ff59f004bc8c713955988398
author_id_fullname_str_mv	b59c8f5c056bac7e6995385f22ad1639_*_Michael Lewis 062f5697ff59f004bc8c713955988398_*_Melitta McNarry
author	Michael Lewis Melitta McNarry
author2	M. A McNarry M. I. C Kingsley M. J Lewis Michael Lewis Melitta McNarry
format	Journal article
container_title	AJP: Regulatory, Integrative and Comparative Physiology
publishDate	2012
institution	Swansea University
issn	0363-6119 1522-1490
doi_str_mv	10.1152/ajpregu.00203.2012
college_str	Faculty of Science and Engineering
hierarchytype
hierarchy_top_id	facultyofscienceandengineering
hierarchy_top_title	Faculty of Science and Engineering
hierarchy_parent_id	facultyofscienceandengineering
hierarchy_parent_title	Faculty of Science and Engineering
department_str	School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
document_store_str	0
active_str	0
description	It is unclear whether pulmonary oxygen uptake (VO2) kinetics demonstrate linear, first order behaviour during supra gas exchange threshold exercise. Resolution of this issue is pertinent to the elucidation of the factors regulating VO2 kinetics, with oxygen availability and utilisation proposed as putative mediators. To re-examine this issue with the advantage of a relatively large sample size, fifty young (24±4 yrs) and fifteen late middle-aged (54±3 yrs) participants completed repeated bouts of moderate and heavy exercise. Pulmonary gas exchange, heart rate (HR) and cardiac output ("Q") variables were measured throughout. The phase II τ was slower during heavy exercise in both young (Mod: 22±9; Hvy: 29±9s; P≤0.001) and middle-aged (Mod: 22±9; Hvy: 30±8s; P≤0.001) individuals. The HR τ was slower during heavy exercise in young (Mod: 33±10; Hvy: 44±15s; P≤0.05) and middle-aged (Mod: 30±12; Hvy: 50±20s; P≤0.05) participants, and the "Q" τ showed a similar trend (Young - Mod: 21±13; Hvy: 28±16 s; Middle-aged - Mod: 32±13; Hvy: 40±15s; P≥0.05). There were no differences in primary component VO2 kinetics between age groups but the middle-aged group had a significantly reduced VO2 slow component amplitude in both absolute (Young: 0.25±0.09; Middle-aged: 0.11±0.06 l∙min-1; P≤0.05) and relative terms (Young: 15±10; Middle-aged: 9±4%; P≤0.05). Thus, VO2 kinetics do not demonstrate dynamic linearity during heavy intensity exercise. Speculatively, the slower phase II τ during heavy exercise might be attributable to reduced oxygen availability. Finally, the primary and slow components of VO2 kinetics appear to be differentially influenced by middle-age.
published_date	2012-10-15T03:14:42Z
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score	11.037581

The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults

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