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Theory of simple biochemical “shape recognition” via diffusion from activator coated nanoshapes

Rob Daniels Orcid Logo

The Journal of Chemical Physics, Volume: 129, Issue: 12, Start page: 125103

Swansea University Author: Rob Daniels Orcid Logo

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DOI (Published version): 10.1063/1.2981056

Abstract

Title: Theory of simple biochemical "shape recognition" via diffusion from activator coated nanoshapesSource: JOURNAL OF CHEMICAL PHYSICS Volume: 129 Issue: 12 Article Number: 125103 Published: SEP 28 2008Abstract: Inspired by recent experiments, we model the shape sensitivity, via a typic...

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Published in: The Journal of Chemical Physics
ISSN: 0021-9606
Published: 2008
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URI: https://cronfa.swan.ac.uk/Record/cronfa12736
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2021-03-17T09:49:51.4604197</datestamp><bib-version>v2</bib-version><id>12736</id><entry>2013-09-03</entry><title>Theory of simple biochemical &#x201C;shape recognition&#x201D; via diffusion from activator coated nanoshapes</title><swanseaauthors><author><sid>23f38c3bb732d4378986bdfaf7b6ee51</sid><ORCID>0000-0002-6933-8144</ORCID><firstname>Rob</firstname><surname>Daniels</surname><name>Rob Daniels</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2013-09-03</date><deptcode>MEDE</deptcode><abstract>Title: Theory of simple biochemical "shape recognition" via diffusion from activator coated nanoshapesSource: JOURNAL OF CHEMICAL PHYSICS Volume: 129 Issue: 12 Article Number: 125103 Published: SEP 28 2008Abstract: Inspired by recent experiments, we model the shape sensitivity, via a typical threshold initiation response, of an underlying complex biochemical reaction network to activator coated nanoshapes. Our theory re-emphasizes that shape effects can be vitally important for the onset of functional behavior in nanopatches and nanoparticles. For certain critical or particular shapes, activator coated nanoshapes do not evoke a threshold response in a complex biochemical network setting, while for different critical or specific shapes, the threshold response is rapidly achieved. The model thus provides a general theoretical understanding for how activator coated nanoshapes can enable a chemical system to perform simple "shape recognition," with an associated " all or nothing" response. The novel and interesting cases of the chemical response due to a nanoshape that shrinks with time is additionally considered, as well as activator coated nanospheres. Possible important applications of this work include the initiation of blood clotting by nanoshapes, nanoshape effects in nanocatalysis, physiological toxicity to nanoparticles, as well as nanoshapes in nanomedicine, drug delivery, and T cell immunological response. The aim of the theory presented here is that it inspires further experimentation on simple biochemical shape recognition via diffusion from activator coated nanoshapes.Impact Factor: 3.149</abstract><type>Journal Article</type><journal>The Journal of Chemical Physics</journal><volume>129</volume><journalNumber>12</journalNumber><paginationStart>125103</paginationStart><paginationEnd/><publisher/><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0021-9606</issnPrint><issnElectronic/><keywords/><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2008</publishedYear><publishedDate>2008-12-31</publishedDate><doi>10.1063/1.2981056</doi><url/><notes>One importance of this work is that it analytically explains theoretically previously published experimental results on the effects of nanoparticle shape on the activation of complex biochemical reactions. Understanding theoretically such reactions are of vital importance for blood clotting, nanocatalysis, and physiological toxicity to nanoparticles. This work therefore possesses great significance for nanomedicine, drug delivery, and T cell immunological response. Excitingly, and of keen interest for future possible experimental applications, this work also outlines how activator coated nanoshapes could enable a chemical system to perform simple "shape recognition".</notes><college>COLLEGE NANME</college><department>Biomedical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDE</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2021-03-17T09:49:51.4604197</lastEdited><Created>2013-09-03T06:11:59.0000000</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Rob</firstname><surname>Daniels</surname><orcid>0000-0002-6933-8144</orcid><order>1</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2021-03-17T09:49:51.4604197 v2 12736 2013-09-03 Theory of simple biochemical “shape recognition” via diffusion from activator coated nanoshapes 23f38c3bb732d4378986bdfaf7b6ee51 0000-0002-6933-8144 Rob Daniels Rob Daniels true false 2013-09-03 MEDE Title: Theory of simple biochemical "shape recognition" via diffusion from activator coated nanoshapesSource: JOURNAL OF CHEMICAL PHYSICS Volume: 129 Issue: 12 Article Number: 125103 Published: SEP 28 2008Abstract: Inspired by recent experiments, we model the shape sensitivity, via a typical threshold initiation response, of an underlying complex biochemical reaction network to activator coated nanoshapes. Our theory re-emphasizes that shape effects can be vitally important for the onset of functional behavior in nanopatches and nanoparticles. For certain critical or particular shapes, activator coated nanoshapes do not evoke a threshold response in a complex biochemical network setting, while for different critical or specific shapes, the threshold response is rapidly achieved. The model thus provides a general theoretical understanding for how activator coated nanoshapes can enable a chemical system to perform simple "shape recognition," with an associated " all or nothing" response. The novel and interesting cases of the chemical response due to a nanoshape that shrinks with time is additionally considered, as well as activator coated nanospheres. Possible important applications of this work include the initiation of blood clotting by nanoshapes, nanoshape effects in nanocatalysis, physiological toxicity to nanoparticles, as well as nanoshapes in nanomedicine, drug delivery, and T cell immunological response. The aim of the theory presented here is that it inspires further experimentation on simple biochemical shape recognition via diffusion from activator coated nanoshapes.Impact Factor: 3.149 Journal Article The Journal of Chemical Physics 129 12 125103 0021-9606 31 12 2008 2008-12-31 10.1063/1.2981056 One importance of this work is that it analytically explains theoretically previously published experimental results on the effects of nanoparticle shape on the activation of complex biochemical reactions. Understanding theoretically such reactions are of vital importance for blood clotting, nanocatalysis, and physiological toxicity to nanoparticles. This work therefore possesses great significance for nanomedicine, drug delivery, and T cell immunological response. Excitingly, and of keen interest for future possible experimental applications, this work also outlines how activator coated nanoshapes could enable a chemical system to perform simple "shape recognition". COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2021-03-17T09:49:51.4604197 2013-09-03T06:11:59.0000000 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Rob Daniels 0000-0002-6933-8144 1
title Theory of simple biochemical “shape recognition” via diffusion from activator coated nanoshapes
spellingShingle Theory of simple biochemical “shape recognition” via diffusion from activator coated nanoshapes
Rob Daniels
title_short Theory of simple biochemical “shape recognition” via diffusion from activator coated nanoshapes
title_full Theory of simple biochemical “shape recognition” via diffusion from activator coated nanoshapes
title_fullStr Theory of simple biochemical “shape recognition” via diffusion from activator coated nanoshapes
title_full_unstemmed Theory of simple biochemical “shape recognition” via diffusion from activator coated nanoshapes
title_sort Theory of simple biochemical “shape recognition” via diffusion from activator coated nanoshapes
author_id_str_mv 23f38c3bb732d4378986bdfaf7b6ee51
author_id_fullname_str_mv 23f38c3bb732d4378986bdfaf7b6ee51_***_Rob Daniels
author Rob Daniels
author2 Rob Daniels
format Journal article
container_title The Journal of Chemical Physics
container_volume 129
container_issue 12
container_start_page 125103
publishDate 2008
institution Swansea University
issn 0021-9606
doi_str_mv 10.1063/1.2981056
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
active_str 0
description Title: Theory of simple biochemical "shape recognition" via diffusion from activator coated nanoshapesSource: JOURNAL OF CHEMICAL PHYSICS Volume: 129 Issue: 12 Article Number: 125103 Published: SEP 28 2008Abstract: Inspired by recent experiments, we model the shape sensitivity, via a typical threshold initiation response, of an underlying complex biochemical reaction network to activator coated nanoshapes. Our theory re-emphasizes that shape effects can be vitally important for the onset of functional behavior in nanopatches and nanoparticles. For certain critical or particular shapes, activator coated nanoshapes do not evoke a threshold response in a complex biochemical network setting, while for different critical or specific shapes, the threshold response is rapidly achieved. The model thus provides a general theoretical understanding for how activator coated nanoshapes can enable a chemical system to perform simple "shape recognition," with an associated " all or nothing" response. The novel and interesting cases of the chemical response due to a nanoshape that shrinks with time is additionally considered, as well as activator coated nanospheres. Possible important applications of this work include the initiation of blood clotting by nanoshapes, nanoshape effects in nanocatalysis, physiological toxicity to nanoparticles, as well as nanoshapes in nanomedicine, drug delivery, and T cell immunological response. The aim of the theory presented here is that it inspires further experimentation on simple biochemical shape recognition via diffusion from activator coated nanoshapes.Impact Factor: 3.149
published_date 2008-12-31T03:14:38Z
_version_ 1763750213170757632
score 11.014067

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