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Inflammation, Obesity, and Neuromodulation in Pregnancy and Fetal Development

Cathy Thornton Orcid Logo, Ruth Jones Orcid Logo, Aled Bryant Orcid Logo

Advances in Neuroimmune Biology, Volume: 1, Issue: 2, Pages: 193 - 203

Swansea University Authors: Cathy Thornton Orcid Logo, Ruth Jones Orcid Logo, Aled Bryant Orcid Logo

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DOI (Published version): 10.3233/NIB-2011-015

Abstract

For over 50 years investigators in reproductive immunology have sought to identify the mechanisms that explain how the immunocompetent mother tolerates the semi-allogeneic fetus. The current immunological paradigm of pregnancy is of active immunological tolerance of fetal cells by the pregnant woman...

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Published in: Advances in Neuroimmune Biology
ISSN: 1878-948X 1878-9498
Published: 2011
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URI: https://cronfa.swan.ac.uk/Record/cronfa12678
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spelling 2011-10-01T00:00:00.0000000 v2 12678 2012-09-13 Inflammation, Obesity, and Neuromodulation in Pregnancy and Fetal Development c71a7a4be7361094d046d312202bce0c 0000-0002-5153-573X Cathy Thornton Cathy Thornton true false a1a281c8720685c422892ef168d4b279 0000-0001-5811-8827 Ruth Jones Ruth Jones true false 021f7adc0923f6d2c2e2fc269758b8fe 0000-0002-4650-4672 Aled Bryant Aled Bryant true false 2012-09-13 BMS For over 50 years investigators in reproductive immunology have sought to identify the mechanisms that explain how the immunocompetent mother tolerates the semi-allogeneic fetus. The current immunological paradigm of pregnancy is of active immunological tolerance of fetal cells by the pregnant woman. A perturbed tolerance response has been hypothesised to underlie adverse pregnancy outcomes. Also there is much interest in how antenatal determinants related to the maternal environment impact on these immunological mechanisms and thereby the development and long term health of the offspring. Environmental insults acting during fetal development can program the structure and function of tissues, organs and body systems. Maternal obesity may be one such insult. While the impact of maternal obesity on immune function of mother and child is relatively unknown, animal models reveal that obesity and/or high-fat feeding during pregnancy have detrimental effects on the development of the pancreas, liver, and the central and peripheral nervous systems. Many of these changes relate to regulation of energy balance and metabolism but there is a growing appreciation of the impact of maternal obesity on inflammatory responses in many tissues of both mother and child. Journal Article Advances in Neuroimmune Biology 1 2 193 203 1878-948X 1878-9498 Pregnancy; obesity; inflammation; fetus; neurodevelopment 31 12 2011 2011-12-31 10.3233/NIB-2011-015 http://iospress.metapress.com/content/xm2k364n99347t67/?p=b56bc6f21c9e4e298f04f07aa7f3b7d6&amp;pi=7 C.A. Thornton, R.H. Jones, A. Doekhie, A.H. Bryant, A.L. Beynon, J.S. Davies COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2011-10-01T00:00:00.0000000 2012-09-13T14:44:36.8202971 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Cathy Thornton 0000-0002-5153-573X 1 Ruth Jones 0000-0001-5811-8827 2 Aled Bryant 0000-0002-4650-4672 3
title Inflammation, Obesity, and Neuromodulation in Pregnancy and Fetal Development
spellingShingle Inflammation, Obesity, and Neuromodulation in Pregnancy and Fetal Development
Cathy Thornton
Ruth Jones
Aled Bryant
title_short Inflammation, Obesity, and Neuromodulation in Pregnancy and Fetal Development
title_full Inflammation, Obesity, and Neuromodulation in Pregnancy and Fetal Development
title_fullStr Inflammation, Obesity, and Neuromodulation in Pregnancy and Fetal Development
title_full_unstemmed Inflammation, Obesity, and Neuromodulation in Pregnancy and Fetal Development
title_sort Inflammation, Obesity, and Neuromodulation in Pregnancy and Fetal Development
author_id_str_mv c71a7a4be7361094d046d312202bce0c
a1a281c8720685c422892ef168d4b279
021f7adc0923f6d2c2e2fc269758b8fe
author_id_fullname_str_mv c71a7a4be7361094d046d312202bce0c_***_Cathy Thornton
a1a281c8720685c422892ef168d4b279_***_Ruth Jones
021f7adc0923f6d2c2e2fc269758b8fe_***_Aled Bryant
author Cathy Thornton
Ruth Jones
Aled Bryant
author2 Cathy Thornton
Ruth Jones
Aled Bryant
format Journal article
container_title Advances in Neuroimmune Biology
container_volume 1
container_issue 2
container_start_page 193
publishDate 2011
institution Swansea University
issn 1878-948X
1878-9498
doi_str_mv 10.3233/NIB-2011-015
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://iospress.metapress.com/content/xm2k364n99347t67/?p=b56bc6f21c9e4e298f04f07aa7f3b7d6&amp;pi=7
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description For over 50 years investigators in reproductive immunology have sought to identify the mechanisms that explain how the immunocompetent mother tolerates the semi-allogeneic fetus. The current immunological paradigm of pregnancy is of active immunological tolerance of fetal cells by the pregnant woman. A perturbed tolerance response has been hypothesised to underlie adverse pregnancy outcomes. Also there is much interest in how antenatal determinants related to the maternal environment impact on these immunological mechanisms and thereby the development and long term health of the offspring. Environmental insults acting during fetal development can program the structure and function of tissues, organs and body systems. Maternal obesity may be one such insult. While the impact of maternal obesity on immune function of mother and child is relatively unknown, animal models reveal that obesity and/or high-fat feeding during pregnancy have detrimental effects on the development of the pancreas, liver, and the central and peripheral nervous systems. Many of these changes relate to regulation of energy balance and metabolism but there is a growing appreciation of the impact of maternal obesity on inflammatory responses in many tissues of both mother and child.
published_date 2011-12-31T03:14:35Z
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