Fatigue in Ankylosing Spondylitis: Treatment Should Focus on Pain Management

Brophy, Sinead; Davies, Helen; Dennis, Michael S.; Cooksey, Roxanne; Husain, Muhammad J.; Irvine, Elizabeth; Siebert, Stefan

doi:10.1016/j.semarthrit.2012.06.002

Journal article 1666 views

Fatigue in Ankylosing Spondylitis: Treatment Should Focus on Pain Management

Sinead Brophy

, Helen Davies, Michael S. Dennis, Roxanne Cooksey, Muhammad J. Husain, Elizabeth Irvine, Stefan Siebert

Seminars in Arthritis and Rheumatism, Volume: 42, Issue: 4, Pages: 361 - 367

Swansea University Author: Sinead Brophy

Full text not available from this repository: check for access using links below.

Check full text

DOI (Published version): 10.1016/j.semarthrit.2012.06.002

Abstract

OBJECTIVES: Fatigue is an important symptom associated with ankylosing spondylitis (AS). This study examines patients' perspectives and clinical associations of fatigue to help inform potential strategies to alleviate fatigue in AS.METHODS: A mixed methods approach was taken to examine fatigue...

Full description

Published in:	Seminars in Arthritis and Rheumatism
ISSN:	00490172
Published:	2013
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa12591
Tags:	Add Tag No Tags, Be the first to tag this record!

first_indexed	2013-07-23T12:08:19Z
last_indexed	2019-07-01T19:15:54Z
id	cronfa12591
recordtype	SURis
fullrecord	<?xml version="1.0"?><rfc1807><datestamp>2019-07-01T14:22:55.5253610</datestamp><bib-version>v2</bib-version><id>12591</id><entry>2012-09-07</entry><title>Fatigue in Ankylosing Spondylitis: Treatment Should Focus on Pain Management</title><swanseaauthors><author><sid>84f5661b35a729f55047f9e793d8798b</sid><ORCID>0000-0001-7417-2858</ORCID><firstname>Sinead</firstname><surname>Brophy</surname><name>Sinead Brophy</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2012-09-07</date><deptcode>HDAT</deptcode><abstract>OBJECTIVES: Fatigue is an important symptom associated with ankylosing spondylitis (AS). This study examines patients' perspectives and clinical associations of fatigue to help inform potential strategies to alleviate fatigue in AS.METHODS: A mixed methods approach was taken to examine fatigue in a cohort of people with AS. Fatigue levels were evaluated from 3 consecutive monthly questionnaires. Open-ended questions on fatigue were analyzed using thematic analysis and logistic regression was used to examine quantitative data. In addition, fatigue levels were examined before and after treatment with anti-tumor necrosis factor (TNF) compared to nontreated controls.RESULTS: Three hundred forty-eight of 385 participants completed a fatigue questionnaire. Fatigue was reported to have significant physical, social, and psychological effects. A third of the participants reported that there was nothing they could do to reduce their fatigue, whereas other participants reported that medication, exercise, and resting helped. The main factor associated with fatigue was pain [β-coefficient: 0.74 (95% CI: 0.66 to 0.81)], whereas depression was much less strongly associated. However, these factors only explained 40% of the variation in fatigue levels. Starting anti-TNF therapy reduced fatigue and pain levels compared to the period of time before taking anti-TNF [difference: 14.4 (95% CI: 5.3 to 23.5) on a scale of 0-100] and this reduction was not seen in controls over the same period.CONCLUSIONS: Fatigue is not strongly associated with anxiety, motivation, and depression; instead the factor most associated with fatigue is pain. This suggests that in addition to treatments to reduce disease activity, strategies for alleviating fatigue in AS should focus on pain management techniques and actively treating inflammation.</abstract><type>Journal Article</type><journal>Seminars in Arthritis and Rheumatism</journal><volume>42</volume><journalNumber>4</journalNumber><paginationStart>361</paginationStart><paginationEnd>367</paginationEnd><publisher/><issnPrint>00490172</issnPrint><keywords/><publishedDay>28</publishedDay><publishedMonth>2</publishedMonth><publishedYear>2013</publishedYear><publishedDate>2013-02-28</publishedDate><doi>10.1016/j.semarthrit.2012.06.002</doi><url/><notes>Epub ahead of print</notes><college>COLLEGE NANME</college><department>Health Data Science</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>HDAT</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2019-07-01T14:22:55.5253610</lastEdited><Created>2012-09-07T14:59:05.2456103</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Sinead</firstname><surname>Brophy</surname><orcid>0000-0001-7417-2858</orcid><order>1</order></author><author><firstname>Helen</firstname><surname>Davies</surname><order>2</order></author><author><firstname>Michael S.</firstname><surname>Dennis</surname><order>3</order></author><author><firstname>Roxanne</firstname><surname>Cooksey</surname><order>4</order></author><author><firstname>Muhammad J.</firstname><surname>Husain</surname><order>5</order></author><author><firstname>Elizabeth</firstname><surname>Irvine</surname><order>6</order></author><author><firstname>Stefan</firstname><surname>Siebert</surname><order>7</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling	2019-07-01T14:22:55.5253610 v2 12591 2012-09-07 Fatigue in Ankylosing Spondylitis: Treatment Should Focus on Pain Management 84f5661b35a729f55047f9e793d8798b 0000-0001-7417-2858 Sinead Brophy Sinead Brophy true false 2012-09-07 HDAT OBJECTIVES: Fatigue is an important symptom associated with ankylosing spondylitis (AS). This study examines patients' perspectives and clinical associations of fatigue to help inform potential strategies to alleviate fatigue in AS.METHODS: A mixed methods approach was taken to examine fatigue in a cohort of people with AS. Fatigue levels were evaluated from 3 consecutive monthly questionnaires. Open-ended questions on fatigue were analyzed using thematic analysis and logistic regression was used to examine quantitative data. In addition, fatigue levels were examined before and after treatment with anti-tumor necrosis factor (TNF) compared to nontreated controls.RESULTS: Three hundred forty-eight of 385 participants completed a fatigue questionnaire. Fatigue was reported to have significant physical, social, and psychological effects. A third of the participants reported that there was nothing they could do to reduce their fatigue, whereas other participants reported that medication, exercise, and resting helped. The main factor associated with fatigue was pain [β-coefficient: 0.74 (95% CI: 0.66 to 0.81)], whereas depression was much less strongly associated. However, these factors only explained 40% of the variation in fatigue levels. Starting anti-TNF therapy reduced fatigue and pain levels compared to the period of time before taking anti-TNF [difference: 14.4 (95% CI: 5.3 to 23.5) on a scale of 0-100] and this reduction was not seen in controls over the same period.CONCLUSIONS: Fatigue is not strongly associated with anxiety, motivation, and depression; instead the factor most associated with fatigue is pain. This suggests that in addition to treatments to reduce disease activity, strategies for alleviating fatigue in AS should focus on pain management techniques and actively treating inflammation. Journal Article Seminars in Arthritis and Rheumatism 42 4 361 367 00490172 28 2 2013 2013-02-28 10.1016/j.semarthrit.2012.06.002 Epub ahead of print COLLEGE NANME Health Data Science COLLEGE CODE HDAT Swansea University 2019-07-01T14:22:55.5253610 2012-09-07T14:59:05.2456103 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Sinead Brophy 0000-0001-7417-2858 1 Helen Davies 2 Michael S. Dennis 3 Roxanne Cooksey 4 Muhammad J. Husain 5 Elizabeth Irvine 6 Stefan Siebert 7
title	Fatigue in Ankylosing Spondylitis: Treatment Should Focus on Pain Management
spellingShingle	Fatigue in Ankylosing Spondylitis: Treatment Should Focus on Pain Management Sinead Brophy
title_short	Fatigue in Ankylosing Spondylitis: Treatment Should Focus on Pain Management
title_full	Fatigue in Ankylosing Spondylitis: Treatment Should Focus on Pain Management
title_fullStr	Fatigue in Ankylosing Spondylitis: Treatment Should Focus on Pain Management
title_full_unstemmed	Fatigue in Ankylosing Spondylitis: Treatment Should Focus on Pain Management
title_sort	Fatigue in Ankylosing Spondylitis: Treatment Should Focus on Pain Management
author_id_str_mv	84f5661b35a729f55047f9e793d8798b
author_id_fullname_str_mv	84f5661b35a729f55047f9e793d8798b_***_Sinead Brophy
author	Sinead Brophy
author2	Sinead Brophy Helen Davies Michael S. Dennis Roxanne Cooksey Muhammad J. Husain Elizabeth Irvine Stefan Siebert
format	Journal article
container_title	Seminars in Arthritis and Rheumatism
container_volume	42
container_issue	4
container_start_page	361
publishDate	2013
institution	Swansea University
issn	00490172
doi_str_mv	10.1016/j.semarthrit.2012.06.002
college_str	Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str	0
active_str	0
description	OBJECTIVES: Fatigue is an important symptom associated with ankylosing spondylitis (AS). This study examines patients' perspectives and clinical associations of fatigue to help inform potential strategies to alleviate fatigue in AS.METHODS: A mixed methods approach was taken to examine fatigue in a cohort of people with AS. Fatigue levels were evaluated from 3 consecutive monthly questionnaires. Open-ended questions on fatigue were analyzed using thematic analysis and logistic regression was used to examine quantitative data. In addition, fatigue levels were examined before and after treatment with anti-tumor necrosis factor (TNF) compared to nontreated controls.RESULTS: Three hundred forty-eight of 385 participants completed a fatigue questionnaire. Fatigue was reported to have significant physical, social, and psychological effects. A third of the participants reported that there was nothing they could do to reduce their fatigue, whereas other participants reported that medication, exercise, and resting helped. The main factor associated with fatigue was pain [β-coefficient: 0.74 (95% CI: 0.66 to 0.81)], whereas depression was much less strongly associated. However, these factors only explained 40% of the variation in fatigue levels. Starting anti-TNF therapy reduced fatigue and pain levels compared to the period of time before taking anti-TNF [difference: 14.4 (95% CI: 5.3 to 23.5) on a scale of 0-100] and this reduction was not seen in controls over the same period.CONCLUSIONS: Fatigue is not strongly associated with anxiety, motivation, and depression; instead the factor most associated with fatigue is pain. This suggests that in addition to treatments to reduce disease activity, strategies for alleviating fatigue in AS should focus on pain management techniques and actively treating inflammation.
published_date	2013-02-28T03:14:30Z
_version_	1763750203983134720
score	11.036837

Fatigue in Ankylosing Spondylitis: Treatment Should Focus on Pain Management

Similar Items