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Mass spectrometry: from proteomics to metabolomics and lipidomics

William Griffiths Orcid Logo, Yuqin Wang

Chemical Society Reviews, Volume: 38, Issue: 7, Start page: 1882

Swansea University Author: William Griffiths Orcid Logo

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DOI (Published version): 10.1039/B618553N

Abstract

Mass spectrometry (MS) in combination with liquid chromatography (LC), i.e. LC-MS, is the key analytical technique on which the emerging “omics” technologies of proteomics, metabolomics and lipidomics are based. It provides both structural and quantitative data and can be used in a “global” or “targ...

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Published in: Chemical Society Reviews
ISSN: 0306-0012 1460-4744
Published: 2009
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URI: https://cronfa.swan.ac.uk/Record/cronfa10948
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last_indexed 2018-02-09T04:40:13Z
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spelling 2011-10-01T00:00:00.0000000 v2 10948 2012-06-05 Mass spectrometry: from proteomics to metabolomics and lipidomics 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2012-06-05 BMS Mass spectrometry (MS) in combination with liquid chromatography (LC), i.e. LC-MS, is the key analytical technique on which the emerging “omics” technologies of proteomics, metabolomics and lipidomics are based. It provides both structural and quantitative data and can be used in a “global” or “targeted” manner allowing on the one hand the identification of thousands of proteins from a tissue, or on the other the detection of biologically active metabolites at levels of a few parts-per-billion. It can be expected that the continued incremental developments in LC-MS along with data-handling routines will soon bear fruit in the quest for a greater understanding of human disease, leading to new drug targets and therapies. This tutorial review on proteomics, metabolomics and lipidomics will be of interest to the biochemical, biomedical and pharmaceutical communities, as well as those working in other branches of analytical bioscience. Other Chemical Society Reviews 38 7 1882 0306-0012 1460-4744 31 12 2009 2009-12-31 10.1039/B618553N COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2011-10-01T00:00:00.0000000 2012-06-05T16:35:03.8271324 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine William Griffiths 0000-0002-4129-6616 1 Yuqin Wang 2
title Mass spectrometry: from proteomics to metabolomics and lipidomics
spellingShingle Mass spectrometry: from proteomics to metabolomics and lipidomics
William Griffiths
title_short Mass spectrometry: from proteomics to metabolomics and lipidomics
title_full Mass spectrometry: from proteomics to metabolomics and lipidomics
title_fullStr Mass spectrometry: from proteomics to metabolomics and lipidomics
title_full_unstemmed Mass spectrometry: from proteomics to metabolomics and lipidomics
title_sort Mass spectrometry: from proteomics to metabolomics and lipidomics
author_id_str_mv 3316b1d1b524be1831790933eed1c26e
author_id_fullname_str_mv 3316b1d1b524be1831790933eed1c26e_***_William Griffiths
author William Griffiths
author2 William Griffiths
Yuqin Wang
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container_title Chemical Society Reviews
container_volume 38
container_issue 7
container_start_page 1882
publishDate 2009
institution Swansea University
issn 0306-0012
1460-4744
doi_str_mv 10.1039/B618553N
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description Mass spectrometry (MS) in combination with liquid chromatography (LC), i.e. LC-MS, is the key analytical technique on which the emerging “omics” technologies of proteomics, metabolomics and lipidomics are based. It provides both structural and quantitative data and can be used in a “global” or “targeted” manner allowing on the one hand the identification of thousands of proteins from a tissue, or on the other the detection of biologically active metabolites at levels of a few parts-per-billion. It can be expected that the continued incremental developments in LC-MS along with data-handling routines will soon bear fruit in the quest for a greater understanding of human disease, leading to new drug targets and therapies. This tutorial review on proteomics, metabolomics and lipidomics will be of interest to the biochemical, biomedical and pharmaceutical communities, as well as those working in other branches of analytical bioscience.
published_date 2009-12-31T03:12:30Z
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