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Why steroidomics in brain?

William Griffiths Orcid Logo

European Journal of Lipid Science and Technology, Volume: 108, Issue: 9, Pages: 707 - 708

Swansea University Author: William Griffiths Orcid Logo

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DOI (Published version): 10.1002/ejlt.200600162

Abstract

In the 1980’s it was realised that steroids could be biosynthesised in brain, and that neurosteroids exert effects on the nervous system by modulating neurotransmission. It is now recognised that neurosteroids play a physiological role in cognitive aging, and havebeen proposed as biomarkers of this...

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Published in: European Journal of Lipid Science and Technology
ISSN: 1438-7697 1438-9312
Published: 2006
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URI: https://cronfa.swan.ac.uk/Record/cronfa10945
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last_indexed 2018-02-09T04:40:13Z
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spelling 2011-10-01T00:00:00.0000000 v2 10945 2012-06-05 Why steroidomics in brain? 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2012-06-05 BMS In the 1980’s it was realised that steroids could be biosynthesised in brain, and that neurosteroids exert effects on the nervous system by modulating neurotransmission. It is now recognised that neurosteroids play a physiological role in cognitive aging, and havebeen proposed as biomarkers of this process. However, the specific functions of neurosteroids have yet to be fully established. Cholesterol, the precursor of neurosteroids, is also metabolised in brain to neurosterols, which are themselves implicated in neurodegenerative diseases such as Alzheimer’s disease and Lewy body dementia, and are suggested as biomarkers of disease. There is now a requirement for research efforts to focus on the development and implementation of sensitive and specific methods for the qualitative and quantitative lipidomic profiling of neurosterols and neurosteroids in brain, and to investigate how these profiles change according to location, and with age, stress, and neurological disease. Concurrent to lipidomic investigations, proteomic studies are required to identify, locate and quantify the enzymes responsible for steroidogenesis and steroid metabolism in brain. Journal Article European Journal of Lipid Science and Technology 108 9 707 708 1438-7697 1438-9312 31 12 2006 2006-12-31 10.1002/ejlt.200600162 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2011-10-01T00:00:00.0000000 2012-06-05T16:23:46.1516966 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine William Griffiths 0000-0002-4129-6616 1
title Why steroidomics in brain?
spellingShingle Why steroidomics in brain?
William Griffiths
title_short Why steroidomics in brain?
title_full Why steroidomics in brain?
title_fullStr Why steroidomics in brain?
title_full_unstemmed Why steroidomics in brain?
title_sort Why steroidomics in brain?
author_id_str_mv 3316b1d1b524be1831790933eed1c26e
author_id_fullname_str_mv 3316b1d1b524be1831790933eed1c26e_***_William Griffiths
author William Griffiths
author2 William Griffiths
format Journal article
container_title European Journal of Lipid Science and Technology
container_volume 108
container_issue 9
container_start_page 707
publishDate 2006
institution Swansea University
issn 1438-7697
1438-9312
doi_str_mv 10.1002/ejlt.200600162
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description In the 1980’s it was realised that steroids could be biosynthesised in brain, and that neurosteroids exert effects on the nervous system by modulating neurotransmission. It is now recognised that neurosteroids play a physiological role in cognitive aging, and havebeen proposed as biomarkers of this process. However, the specific functions of neurosteroids have yet to be fully established. Cholesterol, the precursor of neurosteroids, is also metabolised in brain to neurosterols, which are themselves implicated in neurodegenerative diseases such as Alzheimer’s disease and Lewy body dementia, and are suggested as biomarkers of disease. There is now a requirement for research efforts to focus on the development and implementation of sensitive and specific methods for the qualitative and quantitative lipidomic profiling of neurosterols and neurosteroids in brain, and to investigate how these profiles change according to location, and with age, stress, and neurological disease. Concurrent to lipidomic investigations, proteomic studies are required to identify, locate and quantify the enzymes responsible for steroidogenesis and steroid metabolism in brain.
published_date 2006-12-31T03:12:30Z
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score 11.014358

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