Journal article 1157 views
Why steroidomics in brain?
William Griffiths 
European Journal of Lipid Science and Technology, Volume: 108, Issue: 9, Pages: 707 - 708
Swansea University Author:
William Griffiths
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1002/ejlt.200600162
Abstract
In the 1980’s it was realised that steroids could be biosynthesised in brain, and that neurosteroids exert effects on the nervous system by modulating neurotransmission. It is now recognised that neurosteroids play a physiological role in cognitive aging, and havebeen proposed as biomarkers of this...
| Published in: | European Journal of Lipid Science and Technology |
|---|---|
| ISSN: | 1438-7697 1438-9312 |
| Published: |
2006
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa10945 |
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2013-07-23T12:04:40Z |
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| last_indexed |
2018-02-09T04:40:13Z |
| id |
cronfa10945 |
| recordtype |
SURis |
| fullrecord |
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| spelling |
2011-10-01T00:00:00.0000000 v2 10945 2012-06-05 Why steroidomics in brain? 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2012-06-05 MEDS In the 1980’s it was realised that steroids could be biosynthesised in brain, and that neurosteroids exert effects on the nervous system by modulating neurotransmission. It is now recognised that neurosteroids play a physiological role in cognitive aging, and havebeen proposed as biomarkers of this process. However, the specific functions of neurosteroids have yet to be fully established. Cholesterol, the precursor of neurosteroids, is also metabolised in brain to neurosterols, which are themselves implicated in neurodegenerative diseases such as Alzheimer’s disease and Lewy body dementia, and are suggested as biomarkers of disease. There is now a requirement for research efforts to focus on the development and implementation of sensitive and specific methods for the qualitative and quantitative lipidomic profiling of neurosterols and neurosteroids in brain, and to investigate how these profiles change according to location, and with age, stress, and neurological disease. Concurrent to lipidomic investigations, proteomic studies are required to identify, locate and quantify the enzymes responsible for steroidogenesis and steroid metabolism in brain. Journal Article European Journal of Lipid Science and Technology 108 9 707 708 1438-7697 1438-9312 31 12 2006 2006-12-31 10.1002/ejlt.200600162 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2011-10-01T00:00:00.0000000 2012-06-05T16:23:46.1516966 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine William Griffiths 0000-0002-4129-6616 1 |
| title |
Why steroidomics in brain? |
| spellingShingle |
Why steroidomics in brain? William Griffiths |
| title_short |
Why steroidomics in brain? |
| title_full |
Why steroidomics in brain? |
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Why steroidomics in brain? |
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Why steroidomics in brain? |
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Why steroidomics in brain? |
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3316b1d1b524be1831790933eed1c26e |
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3316b1d1b524be1831790933eed1c26e_***_William Griffiths |
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William Griffiths |
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William Griffiths |
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Journal article |
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European Journal of Lipid Science and Technology |
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108 |
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9 |
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707 |
| publishDate |
2006 |
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Swansea University |
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1438-7697 1438-9312 |
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10.1002/ejlt.200600162 |
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Faculty of Medicine, Health and Life Sciences |
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Faculty of Medicine, Health and Life Sciences |
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Faculty of Medicine, Health and Life Sciences |
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Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
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| description |
In the 1980’s it was realised that steroids could be biosynthesised in brain, and that neurosteroids exert effects on the nervous system by modulating neurotransmission. It is now recognised that neurosteroids play a physiological role in cognitive aging, and havebeen proposed as biomarkers of this process. However, the specific functions of neurosteroids have yet to be fully established. Cholesterol, the precursor of neurosteroids, is also metabolised in brain to neurosterols, which are themselves implicated in neurodegenerative diseases such as Alzheimer’s disease and Lewy body dementia, and are suggested as biomarkers of disease. There is now a requirement for research efforts to focus on the development and implementation of sensitive and specific methods for the qualitative and quantitative lipidomic profiling of neurosterols and neurosteroids in brain, and to investigate how these profiles change according to location, and with age, stress, and neurological disease. Concurrent to lipidomic investigations, proteomic studies are required to identify, locate and quantify the enzymes responsible for steroidogenesis and steroid metabolism in brain. |
| published_date |
2006-12-31T18:22:26Z |
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1821430772264861696 |
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11.047609 |