Analysis of Bile Acids

Sjövall, J; Griffiths, William; Setchell, K.D.R; Mano, N; Goto, J

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Analysis of Bile Acids

J Sjövall, William Griffiths

, K.D.R Setchell, N Mano, J Goto

Steroid Analysis,

Swansea University Author: William Griffiths

Abstract

Bile acids constitute a large family of steroids in vertebrates, normally formed from cholesterol and carrying a carboxyl group in a side-chain of variable length. Bile alcohols, also formed from cholesterol, have similar structures as bile acids, except for the absence of a carboxyl group in the st...

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Published in:	Steroid Analysis,
Published:	2010
URI:	https://cronfa.swan.ac.uk/Record/cronfa10943
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first_indexed	2013-07-23T12:04:39Z
last_indexed	2018-02-09T04:40:13Z
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recordtype	SURis
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spelling	2011-10-01T00:00:00.0000000 v2 10943 2012-06-05 Analysis of Bile Acids 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2012-06-05 BMS Bile acids constitute a large family of steroids in vertebrates, normally formed from cholesterol and carrying a carboxyl group in a side-chain of variable length. Bile alcohols, also formed from cholesterol, have similar structures as bile acids, except for the absence of a carboxyl group in the steroid skeleton. The conversion of cholesterol to bile acids and/or bile alcohols is of major importance for maintenance of cholesterol homeostasis, both from quantitative and regulatory points of view. Appropriately conjugated bile acids and bile alcohols (also referred to as bile salts) are secreted in bile and serve vital functions in the absorption of lipids and lipid-soluble compounds. Reliable analytical methods are required for studies of the functions and pathophysiological importance of the variety of bile acids and bile alcohols present in living organisms. When combined with genetic and proteomic studies, analysis of these small molecules (in today’s terminology: metabolomics, steroidomics, sterolomics, cholanoidomics, etc.) will lead to deeper understandingof the integrated metabolic processes in lipid metabolism. Book chapter Steroid Analysis, 31 12 2010 2010-12-31 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2011-10-01T00:00:00.0000000 2012-06-05T16:12:35.1933156 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine J Sjövall 1 William Griffiths 0000-0002-4129-6616 2 K.D.R Setchell 3 N Mano 4 J Goto 5
title	Analysis of Bile Acids
spellingShingle	Analysis of Bile Acids William Griffiths
title_short	Analysis of Bile Acids
title_full	Analysis of Bile Acids
title_fullStr	Analysis of Bile Acids
title_full_unstemmed	Analysis of Bile Acids
title_sort	Analysis of Bile Acids
author_id_str_mv	3316b1d1b524be1831790933eed1c26e
author_id_fullname_str_mv	3316b1d1b524be1831790933eed1c26e_***_William Griffiths
author	William Griffiths
author2	J Sjövall William Griffiths K.D.R Setchell N Mano J Goto
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container_title	Steroid Analysis,
publishDate	2010
institution	Swansea University
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description	Bile acids constitute a large family of steroids in vertebrates, normally formed from cholesterol and carrying a carboxyl group in a side-chain of variable length. Bile alcohols, also formed from cholesterol, have similar structures as bile acids, except for the absence of a carboxyl group in the steroid skeleton. The conversion of cholesterol to bile acids and/or bile alcohols is of major importance for maintenance of cholesterol homeostasis, both from quantitative and regulatory points of view. Appropriately conjugated bile acids and bile alcohols (also referred to as bile salts) are secreted in bile and serve vital functions in the absorption of lipids and lipid-soluble compounds. Reliable analytical methods are required for studies of the functions and pathophysiological importance of the variety of bile acids and bile alcohols present in living organisms. When combined with genetic and proteomic studies, analysis of these small molecules (in today’s terminology: metabolomics, steroidomics, sterolomics, cholanoidomics, etc.) will lead to deeper understandingof the integrated metabolic processes in lipid metabolism.
published_date	2010-12-31T03:12:29Z
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score	11.013371

Analysis of Bile Acids

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