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Effect of Capping Protein on a Growing Filopodium

Rob Daniels Orcid Logo

Biophysical Journal, Volume: 98, Issue: 7, Pages: 1139 - 1148

Swansea University Author: Rob Daniels Orcid Logo

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DOI (Published version): 10.1016/j.bpj.2009.11.053

Abstract

Title: Effect of Capping Protein on a Growing FilopodiumSource: BIOPHYSICAL JOURNAL Volume: 98 Issue: 7 Pages: 1139-1148 Published: APR 7 2010Abstract: Filopodia, or the growth of bundles of biological fibers outwards from a biological cell surface while enclosed in a membrane tube, are implicated i...

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Published in: Biophysical Journal
ISSN: 0006-3495
Published: 2010
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URI: https://cronfa.swan.ac.uk/Record/cronfa10920
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2021-03-17T09:48:35.4602293</datestamp><bib-version>v2</bib-version><id>10920</id><entry>2013-09-03</entry><title>Effect of Capping Protein on a Growing Filopodium</title><swanseaauthors><author><sid>23f38c3bb732d4378986bdfaf7b6ee51</sid><ORCID>0000-0002-6933-8144</ORCID><firstname>Rob</firstname><surname>Daniels</surname><name>Rob Daniels</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2013-09-03</date><deptcode>MEDE</deptcode><abstract>Title: Effect of Capping Protein on a Growing FilopodiumSource: BIOPHYSICAL JOURNAL Volume: 98 Issue: 7 Pages: 1139-1148 Published: APR 7 2010Abstract: Filopodia, or the growth of bundles of biological fibers outwards from a biological cell surface while enclosed in a membrane tube, are implicated in many processes vital to life. This study models the effect of capping protein on such filopodia, paying close attention to the polymerization dynamics of biological fiber bundles within long membrane tubes. Due to the effects of capping protein, the number of fibers in the filopodium bundle decreases down the length of the enclosing membrane tube. This decrease in the number of fibers down the length of a growing filopodium is found to have profound implications for the dynamics and stability of filopodia in general. This study theoretically finds that the presence of even a relatively modest amount of capping protein can have a large effect on the growth of typical filopodia, such as can be found in fibroblasts, keratocytes. and neuronal growth cones. As an illustration of this modeling work, this study investigates the striking example of the acrosomal reaction in the sea cucumber Thyone, whose filopodia can grow remarkably quickly to similar to 90 mu m in similar to 10 s, and where the number of fibers is known to decrease down the length of the filopodium, presumably due to progressive fiber end-capping occurring as the filopodium grows. Realistic future dynamical theories for filopodium growth are likely to rely on an accurate treatment of the kinds of capping protein effects analyzed in this work.Impact Factor: 4.683</abstract><type>Journal Article</type><journal>Biophysical Journal</journal><volume>98</volume><journalNumber>7</journalNumber><paginationStart>1139</paginationStart><paginationEnd>1148</paginationEnd><publisher/><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0006-3495</issnPrint><issnElectronic/><keywords/><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2010</publishedYear><publishedDate>2010-12-31</publishedDate><doi>10.1016/j.bpj.2009.11.053</doi><url/><notes>The dynamics and stability of long, thin, protrusions from cells (called filopodia) are critical for many processes vital to life. This work is important in that it describes theoretically for the first time the effect of capping protein on growing filopodia. Using this modelling work we are able to quantitatively fit experimental data on real filopdoia for the first time realistically. This work has therefore great significance for suggesting new possible therapeutic strategies for diseases caused by when filopodium dynamics runs amok.</notes><college>COLLEGE NANME</college><department>Biomedical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDE</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2021-03-17T09:48:35.4602293</lastEdited><Created>2013-09-03T06:11:57.0000000</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Rob</firstname><surname>Daniels</surname><orcid>0000-0002-6933-8144</orcid><order>1</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2021-03-17T09:48:35.4602293 v2 10920 2013-09-03 Effect of Capping Protein on a Growing Filopodium 23f38c3bb732d4378986bdfaf7b6ee51 0000-0002-6933-8144 Rob Daniels Rob Daniels true false 2013-09-03 MEDE Title: Effect of Capping Protein on a Growing FilopodiumSource: BIOPHYSICAL JOURNAL Volume: 98 Issue: 7 Pages: 1139-1148 Published: APR 7 2010Abstract: Filopodia, or the growth of bundles of biological fibers outwards from a biological cell surface while enclosed in a membrane tube, are implicated in many processes vital to life. This study models the effect of capping protein on such filopodia, paying close attention to the polymerization dynamics of biological fiber bundles within long membrane tubes. Due to the effects of capping protein, the number of fibers in the filopodium bundle decreases down the length of the enclosing membrane tube. This decrease in the number of fibers down the length of a growing filopodium is found to have profound implications for the dynamics and stability of filopodia in general. This study theoretically finds that the presence of even a relatively modest amount of capping protein can have a large effect on the growth of typical filopodia, such as can be found in fibroblasts, keratocytes. and neuronal growth cones. As an illustration of this modeling work, this study investigates the striking example of the acrosomal reaction in the sea cucumber Thyone, whose filopodia can grow remarkably quickly to similar to 90 mu m in similar to 10 s, and where the number of fibers is known to decrease down the length of the filopodium, presumably due to progressive fiber end-capping occurring as the filopodium grows. Realistic future dynamical theories for filopodium growth are likely to rely on an accurate treatment of the kinds of capping protein effects analyzed in this work.Impact Factor: 4.683 Journal Article Biophysical Journal 98 7 1139 1148 0006-3495 31 12 2010 2010-12-31 10.1016/j.bpj.2009.11.053 The dynamics and stability of long, thin, protrusions from cells (called filopodia) are critical for many processes vital to life. This work is important in that it describes theoretically for the first time the effect of capping protein on growing filopodia. Using this modelling work we are able to quantitatively fit experimental data on real filopdoia for the first time realistically. This work has therefore great significance for suggesting new possible therapeutic strategies for diseases caused by when filopodium dynamics runs amok. COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2021-03-17T09:48:35.4602293 2013-09-03T06:11:57.0000000 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Rob Daniels 0000-0002-6933-8144 1
title Effect of Capping Protein on a Growing Filopodium
spellingShingle Effect of Capping Protein on a Growing Filopodium
Rob Daniels
title_short Effect of Capping Protein on a Growing Filopodium
title_full Effect of Capping Protein on a Growing Filopodium
title_fullStr Effect of Capping Protein on a Growing Filopodium
title_full_unstemmed Effect of Capping Protein on a Growing Filopodium
title_sort Effect of Capping Protein on a Growing Filopodium
author_id_str_mv 23f38c3bb732d4378986bdfaf7b6ee51
author_id_fullname_str_mv 23f38c3bb732d4378986bdfaf7b6ee51_***_Rob Daniels
author Rob Daniels
author2 Rob Daniels
format Journal article
container_title Biophysical Journal
container_volume 98
container_issue 7
container_start_page 1139
publishDate 2010
institution Swansea University
issn 0006-3495
doi_str_mv 10.1016/j.bpj.2009.11.053
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
active_str 0
description Title: Effect of Capping Protein on a Growing FilopodiumSource: BIOPHYSICAL JOURNAL Volume: 98 Issue: 7 Pages: 1139-1148 Published: APR 7 2010Abstract: Filopodia, or the growth of bundles of biological fibers outwards from a biological cell surface while enclosed in a membrane tube, are implicated in many processes vital to life. This study models the effect of capping protein on such filopodia, paying close attention to the polymerization dynamics of biological fiber bundles within long membrane tubes. Due to the effects of capping protein, the number of fibers in the filopodium bundle decreases down the length of the enclosing membrane tube. This decrease in the number of fibers down the length of a growing filopodium is found to have profound implications for the dynamics and stability of filopodia in general. This study theoretically finds that the presence of even a relatively modest amount of capping protein can have a large effect on the growth of typical filopodia, such as can be found in fibroblasts, keratocytes. and neuronal growth cones. As an illustration of this modeling work, this study investigates the striking example of the acrosomal reaction in the sea cucumber Thyone, whose filopodia can grow remarkably quickly to similar to 90 mu m in similar to 10 s, and where the number of fibers is known to decrease down the length of the filopodium, presumably due to progressive fiber end-capping occurring as the filopodium grows. Realistic future dynamical theories for filopodium growth are likely to rely on an accurate treatment of the kinds of capping protein effects analyzed in this work.Impact Factor: 4.683
published_date 2010-12-31T03:12:28Z
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score 11.01409

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