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Monomer Depletion, Pressure Difference, and Membrane Tube Radius Reduction due to Fiber Polymerization in Microspikes

Rob Daniels Orcid Logo

Physical Review Letters, Volume: 100, Issue: 4, Start page: 048103

Swansea University Author: Rob Daniels Orcid Logo

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DOI (Published version): 10.1103/physrevlett.100.048103

Abstract

Title: Monomer depletion, pressure difference, and membrane tube radius reduction due to fiber polymerization in microspikesSource: PHYSICAL REVIEW LETTERS Volume: 100 Issue: 4 Article Number: 048103 Published: FEB 1 2008Abstract: In many processes vital to life, the growth of biological fibers outw...

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Published in: Physical Review Letters
ISSN: 0031-9007 1079-7114
Published: 2008
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URI: https://cronfa.swan.ac.uk/Record/cronfa10919
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2021-03-17T09:49:16.4307732</datestamp><bib-version>v2</bib-version><id>10919</id><entry>2013-09-03</entry><title>Monomer Depletion, Pressure Difference, and Membrane Tube Radius Reduction due to Fiber Polymerization in Microspikes</title><swanseaauthors><author><sid>23f38c3bb732d4378986bdfaf7b6ee51</sid><ORCID>0000-0002-6933-8144</ORCID><firstname>Rob</firstname><surname>Daniels</surname><name>Rob Daniels</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2013-09-03</date><deptcode>MEDE</deptcode><abstract>Title: Monomer depletion, pressure difference, and membrane tube radius reduction due to fiber polymerization in microspikesSource: PHYSICAL REVIEW LETTERS Volume: 100 Issue: 4 Article Number: 048103 Published: FEB 1 2008Abstract: In many processes vital to life, the growth of biological fibers outwards from a membrane surface naturally produces membrane tube tethers or microspikes in biological cells. Here, we investigate the novel effect of pressure difference (due to monomer depletion) on the polymerization dynamics of biological fibers within long membrane tubes. We crucially find that fiber monomers become depleted close to the growing tip as the fiber polymerizes, thus reducing the local pressure, and hence decreasing the membrane tube radius at the tip. This process is found to slow the growth of the fiber, a process which becomes important when we go on to construct a dynamical theory for biopolymer growth in long, narrow tubes. Our result is interesting in that it emphasizes how "passive" biological transport mechanisms such as via pressure differences may play an important role in cell movements.Impact Factor: 7.180</abstract><type>Journal Article</type><journal>Physical Review Letters</journal><volume>100</volume><journalNumber>4</journalNumber><paginationStart>048103</paginationStart><paginationEnd/><publisher/><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0031-9007</issnPrint><issnElectronic>1079-7114</issnElectronic><keywords/><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2008</publishedYear><publishedDate>2008-12-31</publishedDate><doi>10.1103/physrevlett.100.048103</doi><url/><notes>The growth of microspikes on the exterior of cells is vital to many processes required for life. This work is important in that it gives for the first time a comprehensive and novel theory for such microspike dynamics. The significance of this work is that now we understand theoretically the mechanisms behind microspike dynamics, we can begin to alter them physiochemically, and potentially devise new therapeutics for many life threatening diseases where microspike growth goes awry.</notes><college>COLLEGE NANME</college><department>Biomedical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDE</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2021-03-17T09:49:16.4307732</lastEdited><Created>2013-09-03T06:11:56.0000000</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Rob</firstname><surname>Daniels</surname><orcid>0000-0002-6933-8144</orcid><order>1</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2021-03-17T09:49:16.4307732 v2 10919 2013-09-03 Monomer Depletion, Pressure Difference, and Membrane Tube Radius Reduction due to Fiber Polymerization in Microspikes 23f38c3bb732d4378986bdfaf7b6ee51 0000-0002-6933-8144 Rob Daniels Rob Daniels true false 2013-09-03 MEDE Title: Monomer depletion, pressure difference, and membrane tube radius reduction due to fiber polymerization in microspikesSource: PHYSICAL REVIEW LETTERS Volume: 100 Issue: 4 Article Number: 048103 Published: FEB 1 2008Abstract: In many processes vital to life, the growth of biological fibers outwards from a membrane surface naturally produces membrane tube tethers or microspikes in biological cells. Here, we investigate the novel effect of pressure difference (due to monomer depletion) on the polymerization dynamics of biological fibers within long membrane tubes. We crucially find that fiber monomers become depleted close to the growing tip as the fiber polymerizes, thus reducing the local pressure, and hence decreasing the membrane tube radius at the tip. This process is found to slow the growth of the fiber, a process which becomes important when we go on to construct a dynamical theory for biopolymer growth in long, narrow tubes. Our result is interesting in that it emphasizes how "passive" biological transport mechanisms such as via pressure differences may play an important role in cell movements.Impact Factor: 7.180 Journal Article Physical Review Letters 100 4 048103 0031-9007 1079-7114 31 12 2008 2008-12-31 10.1103/physrevlett.100.048103 The growth of microspikes on the exterior of cells is vital to many processes required for life. This work is important in that it gives for the first time a comprehensive and novel theory for such microspike dynamics. The significance of this work is that now we understand theoretically the mechanisms behind microspike dynamics, we can begin to alter them physiochemically, and potentially devise new therapeutics for many life threatening diseases where microspike growth goes awry. COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2021-03-17T09:49:16.4307732 2013-09-03T06:11:56.0000000 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Rob Daniels 0000-0002-6933-8144 1
title Monomer Depletion, Pressure Difference, and Membrane Tube Radius Reduction due to Fiber Polymerization in Microspikes
spellingShingle Monomer Depletion, Pressure Difference, and Membrane Tube Radius Reduction due to Fiber Polymerization in Microspikes
Rob Daniels
title_short Monomer Depletion, Pressure Difference, and Membrane Tube Radius Reduction due to Fiber Polymerization in Microspikes
title_full Monomer Depletion, Pressure Difference, and Membrane Tube Radius Reduction due to Fiber Polymerization in Microspikes
title_fullStr Monomer Depletion, Pressure Difference, and Membrane Tube Radius Reduction due to Fiber Polymerization in Microspikes
title_full_unstemmed Monomer Depletion, Pressure Difference, and Membrane Tube Radius Reduction due to Fiber Polymerization in Microspikes
title_sort Monomer Depletion, Pressure Difference, and Membrane Tube Radius Reduction due to Fiber Polymerization in Microspikes
author_id_str_mv 23f38c3bb732d4378986bdfaf7b6ee51
author_id_fullname_str_mv 23f38c3bb732d4378986bdfaf7b6ee51_***_Rob Daniels
author Rob Daniels
author2 Rob Daniels
format Journal article
container_title Physical Review Letters
container_volume 100
container_issue 4
container_start_page 048103
publishDate 2008
institution Swansea University
issn 0031-9007
1079-7114
doi_str_mv 10.1103/physrevlett.100.048103
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
active_str 0
description Title: Monomer depletion, pressure difference, and membrane tube radius reduction due to fiber polymerization in microspikesSource: PHYSICAL REVIEW LETTERS Volume: 100 Issue: 4 Article Number: 048103 Published: FEB 1 2008Abstract: In many processes vital to life, the growth of biological fibers outwards from a membrane surface naturally produces membrane tube tethers or microspikes in biological cells. Here, we investigate the novel effect of pressure difference (due to monomer depletion) on the polymerization dynamics of biological fibers within long membrane tubes. We crucially find that fiber monomers become depleted close to the growing tip as the fiber polymerizes, thus reducing the local pressure, and hence decreasing the membrane tube radius at the tip. This process is found to slow the growth of the fiber, a process which becomes important when we go on to construct a dynamical theory for biopolymer growth in long, narrow tubes. Our result is interesting in that it emphasizes how "passive" biological transport mechanisms such as via pressure differences may play an important role in cell movements.Impact Factor: 7.180
published_date 2008-12-31T03:12:28Z
_version_ 1763750076115582976
score 11.014067

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