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Targeted Metabolomics for Biomarker Discovery

William J Griffiths, Therese Koal, Yuqin Wang, Matthias Kohl, David P Enot, Hans-Peter Deigner, William Griffiths Orcid Logo

Angewandte Chemie International Edition, Volume: 49, Issue: 32, Pages: 5426 - 5445

Swansea University Author: William Griffiths Orcid Logo

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DOI (Published version): 10.1002/anie.200905579

Abstract

Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis. Applied to biomarker discovery, it includes aspects of pathobiochemistry, systems biology/medicine, and mole...

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Published in: Angewandte Chemie International Edition
ISSN: 1433-7851
Published: 2010
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa10764
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last_indexed 2018-02-09T04:39:51Z
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spelling 2011-10-01T00:00:00.0000000 v2 10764 2012-05-21 Targeted Metabolomics for Biomarker Discovery 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2012-05-21 BMS Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis. Applied to biomarker discovery, it includes aspects of pathobiochemistry, systems biology/medicine, and molecular diagnostics and requires bioinformatics and multivariate statistics. While successfully established in the screening of inborn errors in neonates, metabolomics is now widely used in the characterization and diagnostic research of an ever increasing number of diseases. In this Review we highlight important technical prerequisites as well as recent developments in metabolomics and metabolomics data analysis with special emphasis on their utility in biomarker identification and qualification, as well as targeted metabolomics by employing high-throughput mass spectrometry. Other Angewandte Chemie International Edition 49 32 5426 5445 1433-7851 31 12 2010 2010-12-31 10.1002/anie.200905579 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2011-10-01T00:00:00.0000000 2012-05-21T15:57:39.1735389 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine William J Griffiths 1 Therese Koal 2 Yuqin Wang 3 Matthias Kohl 4 David P Enot 5 Hans-Peter Deigner 6 William Griffiths 0000-0002-4129-6616 7
title Targeted Metabolomics for Biomarker Discovery
spellingShingle Targeted Metabolomics for Biomarker Discovery
William Griffiths
title_short Targeted Metabolomics for Biomarker Discovery
title_full Targeted Metabolomics for Biomarker Discovery
title_fullStr Targeted Metabolomics for Biomarker Discovery
title_full_unstemmed Targeted Metabolomics for Biomarker Discovery
title_sort Targeted Metabolomics for Biomarker Discovery
author_id_str_mv 3316b1d1b524be1831790933eed1c26e
author_id_fullname_str_mv 3316b1d1b524be1831790933eed1c26e_***_William Griffiths
author William Griffiths
author2 William J Griffiths
Therese Koal
Yuqin Wang
Matthias Kohl
David P Enot
Hans-Peter Deigner
William Griffiths
format Other
container_title Angewandte Chemie International Edition
container_volume 49
container_issue 32
container_start_page 5426
publishDate 2010
institution Swansea University
issn 1433-7851
doi_str_mv 10.1002/anie.200905579
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
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description Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis. Applied to biomarker discovery, it includes aspects of pathobiochemistry, systems biology/medicine, and molecular diagnostics and requires bioinformatics and multivariate statistics. While successfully established in the screening of inborn errors in neonates, metabolomics is now widely used in the characterization and diagnostic research of an ever increasing number of diseases. In this Review we highlight important technical prerequisites as well as recent developments in metabolomics and metabolomics data analysis with special emphasis on their utility in biomarker identification and qualification, as well as targeted metabolomics by employing high-throughput mass spectrometry.
published_date 2010-12-31T03:12:15Z
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score 11.017016

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