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Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus

T Tang, Sarah Prior Orcid Logo, K Li, H Ireland, Steve Bain, Steve Hurel, J Cooper, Steve Humphries, Jeffrey Stephens Orcid Logo

Nutrition, Metabolism & Cardiovascular Diseases, Volume: 22, Issue: 5, Pages: 417 - 425

Swansea University Authors: Sarah Prior Orcid Logo, Jeffrey Stephens Orcid Logo

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DOI (Published version): 10.1016/j.numecd.2010.08.001

Abstract

Glutathione peroxidase-1 (GPx-1) is an endogenous anti-oxidant enzyme. The T allele of the GPx-1 rs1050450 (C > T) gene variant is associated with reduced enzyme activity. Our aim was to examine the association between this gene variant and peripheral neuropathy in two cross-sectional sample...

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Published in: Nutrition, Metabolism & Cardiovascular Diseases
Published: 2010
Online Access: http://www.nmcd-journal.com/article/S0939-4753(10)00188-2/abstract
URI: https://cronfa.swan.ac.uk/Record/cronfa10734
first_indexed 2013-07-23T12:04:10Z
last_indexed 2018-02-09T04:39:48Z
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recordtype SURis
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spelling 2014-12-05T15:08:44.4537004 v2 10734 2012-05-09 Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus cdda101035997acfaa6fdf17097f52b2 0000-0001-8703-8092 Sarah Prior Sarah Prior true false 5219d126f97f8f884bdb622099bd41de 0000-0003-2228-086X Jeffrey Stephens Jeffrey Stephens true false 2012-05-09 MEDS Glutathione peroxidase-1 (GPx-1) is an endogenous anti-oxidant enzyme. The T allele of the GPx-1 rs1050450 (C &#62; T) gene variant is associated with reduced enzyme activity. Our aim was to examine the association between this gene variant and peripheral neuropathy in two cross-sectional samples of subjects with diabetes: (i) 773 Caucasian subjects were genotyped from the UCL Diabetes and Cardiovascular disease Study (UDACS) and (ii) 382 Caucasian subjects from the Ealing Diabetes Study (EDS). Peripheral neuropathy status (and oxidised-LDL [Ox-LDL:LDL] and plasma Total Ant-ioxidant Status [TAOS] in UDACS), were analysed in relation to genotype. We observed that: (i) In UDACS, the odds ratio (OR) for peripheral neuropathy in the T allele carriers compared to the CC genotype was 1.61 [1.10–2.28], p = 0.01. This remained significant after adjustment for other risk factors. Ox-LDL:LDL ratio was significantly elevated in T allele carriers (CC vs. CT/TT: 16.3 ± 2.4 v 18.0 ± 2.9 U/mmol LDL, p = 0.02). (ii) In EDS, the OR for peripheral neuropathy in the T allele carriers compared to the CC genotype was 1.95 [1.11–3.42], p = 0.02. This remained significant after adjustment for other risk factors. In conclusion, we observed a significant association between the T allele and peripheral neuropathy and LDL oxidation. This is the first paper to examine the rs1050450 variant in two samples of Caucasian subjects with diabetes. Prospective analysis of the gene variant is required in diabetic and healthy cohorts with measured plasma markers of oxidative stress to investigate the described association further. Journal Article Nutrition, Metabolism & Cardiovascular Diseases 22 5 417 425 Glutathione peroxidase; Oxidative stress; Diabetes; Peripheral neuropathy; Total anti-oxidant status 31 12 2010 2010-12-31 10.1016/j.numecd.2010.08.001 http://www.nmcd-journal.com/article/S0939-4753(10)00188-2/abstract COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2014-12-05T15:08:44.4537004 2012-05-09T11:27:48.3777051 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine T Tang 1 Sarah Prior 0000-0001-8703-8092 2 K Li 3 H Ireland 4 Steve Bain 5 Steve Hurel 6 J Cooper 7 Steve Humphries 8 Jeffrey Stephens 0000-0003-2228-086X 9
title Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus
spellingShingle Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus
Sarah Prior
Jeffrey Stephens
title_short Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus
title_full Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus
title_fullStr Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus
title_full_unstemmed Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus
title_sort Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus
author_id_str_mv cdda101035997acfaa6fdf17097f52b2
5219d126f97f8f884bdb622099bd41de
author_id_fullname_str_mv cdda101035997acfaa6fdf17097f52b2_***_Sarah Prior
5219d126f97f8f884bdb622099bd41de_***_Jeffrey Stephens
author Sarah Prior
Jeffrey Stephens
author2 T Tang
Sarah Prior
K Li
H Ireland
Steve Bain
Steve Hurel
J Cooper
Steve Humphries
Jeffrey Stephens
format Journal article
container_title Nutrition, Metabolism & Cardiovascular Diseases
container_volume 22
container_issue 5
container_start_page 417
publishDate 2010
institution Swansea University
doi_str_mv 10.1016/j.numecd.2010.08.001
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://www.nmcd-journal.com/article/S0939-4753(10)00188-2/abstract
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description Glutathione peroxidase-1 (GPx-1) is an endogenous anti-oxidant enzyme. The T allele of the GPx-1 rs1050450 (C &#62; T) gene variant is associated with reduced enzyme activity. Our aim was to examine the association between this gene variant and peripheral neuropathy in two cross-sectional samples of subjects with diabetes: (i) 773 Caucasian subjects were genotyped from the UCL Diabetes and Cardiovascular disease Study (UDACS) and (ii) 382 Caucasian subjects from the Ealing Diabetes Study (EDS). Peripheral neuropathy status (and oxidised-LDL [Ox-LDL:LDL] and plasma Total Ant-ioxidant Status [TAOS] in UDACS), were analysed in relation to genotype. We observed that: (i) In UDACS, the odds ratio (OR) for peripheral neuropathy in the T allele carriers compared to the CC genotype was 1.61 [1.10–2.28], p = 0.01. This remained significant after adjustment for other risk factors. Ox-LDL:LDL ratio was significantly elevated in T allele carriers (CC vs. CT/TT: 16.3 ± 2.4 v 18.0 ± 2.9 U/mmol LDL, p = 0.02). (ii) In EDS, the OR for peripheral neuropathy in the T allele carriers compared to the CC genotype was 1.95 [1.11–3.42], p = 0.02. This remained significant after adjustment for other risk factors. In conclusion, we observed a significant association between the T allele and peripheral neuropathy and LDL oxidation. This is the first paper to examine the rs1050450 variant in two samples of Caucasian subjects with diabetes. Prospective analysis of the gene variant is required in diabetic and healthy cohorts with measured plasma markers of oxidative stress to investigate the described association further.
published_date 2010-12-31T00:22:45Z
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