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Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus

Danielle Jones, Sarah Prior Orcid Logo, T Tang, Steve Bain, Steve Hurel, Steve Humphries, Jeffrey Stephens

Diabetes Research and Clinical Practice, Volume: 90, Issue: 2, Pages: 196 - 201

Swansea University Authors: Danielle Jones, Sarah Prior Orcid Logo

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DOI (Published version): 10.1016/j.diabres.2010.07.009

Abstract

Mitochondrial superoxide dismutase 2 (SOD2) is an endogenous anti-oxidant enzyme. The rs4880 gene variant results in a C>T substitution, influencing SOD enzymatic activity. This variant has been associated with micro- and macro-vascular complications in diabetes mellitus. Our aim was to exam...

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Published in: Diabetes Research and Clinical Practice
Published: Elsevier 2010
Online Access: http://www.sciencedirect.com/science/article/pii/S0168822710003864
URI: https://cronfa.swan.ac.uk/Record/cronfa10728
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2014-12-05T14:51:52.7201029</datestamp><bib-version>v2</bib-version><id>10728</id><entry>2012-05-09</entry><title>Association between the rs4880 superoxide dismutase 2 (C&gt;T) gene variant and coronary heart disease in diabetes mellitus</title><swanseaauthors><author><sid>4d474dbca816c2c209faef443be18a66</sid><firstname>Danielle</firstname><surname>Jones</surname><name>Danielle Jones</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>cdda101035997acfaa6fdf17097f52b2</sid><ORCID>0000-0001-8703-8092</ORCID><firstname>Sarah</firstname><surname>Prior</surname><name>Sarah Prior</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2012-05-09</date><abstract>Mitochondrial superoxide dismutase 2 (SOD2) is an endogenous anti-oxidant enzyme. The rs4880 gene variant results in a C&amp;#62;T substitution, influencing SOD enzymatic activity. This variant has been associated with micro- and macro-vascular complications in diabetes mellitus. Our aim was to examine the association between this variant and coronary heart disease (CHD) risk in a cross-sectional sample of subjects with diabetes.776 Caucasian subjects with diabetes were genotyped. CHD risk, oxidised-LDL and plasma total anti-oxidant status (TAOS) were analysed in relation to genotype. In females, the TT genotype was associated with CHD (CC/CT/TT: No CHD vs. CHD: 22.4/56.0/21.6% vs. 12.0/50.0/38.0%, p = 0.03; for CC/CT vs. TT, p = 0.01). The odds ratio for CHD associated with the TT genotype compared to CC/CT was 2.22 [95%CI: 1.17&#x2013;4.24], p = 0.01. The TT genotype was also associated with significantly lower plasma TAOS. In males, no association was observed between genotype and CHD risk, but CHD was significantly associated with age, lower HDL, higher triglycerides, higher BMI and cigarette smoking.The TT genotype of this variant is associated with increased CHD risk and lower plasma anti-oxidant defences in females with diabetes. This modest genotype-effect is not apparent in males where traditional risk factors may play a greater role.</abstract><type>Journal Article</type><journal>Diabetes Research and Clinical Practice</journal><volume>90</volume><journalNumber>2</journalNumber><paginationStart>196</paginationStart><paginationEnd>201</paginationEnd><publisher>Elsevier</publisher><issnPrint/><issnElectronic/><keywords>Superoxide dismutase; Gene variant; Oxidative stress; Diabetes; CHD; rs4880; Mitochondria; Total anti-oxidant status</keywords><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2010</publishedYear><publishedDate>2010-12-31</publishedDate><doi>10.1016/j.diabres.2010.07.009</doi><url>http://www.sciencedirect.com/science/article/pii/S0168822710003864</url><notes></notes><college>COLLEGE NANME</college><CollegeCode>COLLEGE CODE</CollegeCode><institution>Swansea University</institution><apcterm/><lastEdited>2014-12-05T14:51:52.7201029</lastEdited><Created>2012-05-09T09:52:11.5327947</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Danielle</firstname><surname>Jones</surname><order>1</order></author><author><firstname>Sarah</firstname><surname>Prior</surname><orcid>0000-0001-8703-8092</orcid><order>2</order></author><author><firstname>T</firstname><surname>Tang</surname><order>3</order></author><author><firstname>Steve</firstname><surname>Bain</surname><order>4</order></author><author><firstname>Steve</firstname><surname>Hurel</surname><order>5</order></author><author><firstname>Steve</firstname><surname>Humphries</surname><order>6</order></author><author><firstname>Jeffrey</firstname><surname>Stephens</surname><order>7</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2014-12-05T14:51:52.7201029 v2 10728 2012-05-09 Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus 4d474dbca816c2c209faef443be18a66 Danielle Jones Danielle Jones true false cdda101035997acfaa6fdf17097f52b2 0000-0001-8703-8092 Sarah Prior Sarah Prior true false 2012-05-09 Mitochondrial superoxide dismutase 2 (SOD2) is an endogenous anti-oxidant enzyme. The rs4880 gene variant results in a C&#62;T substitution, influencing SOD enzymatic activity. This variant has been associated with micro- and macro-vascular complications in diabetes mellitus. Our aim was to examine the association between this variant and coronary heart disease (CHD) risk in a cross-sectional sample of subjects with diabetes.776 Caucasian subjects with diabetes were genotyped. CHD risk, oxidised-LDL and plasma total anti-oxidant status (TAOS) were analysed in relation to genotype. In females, the TT genotype was associated with CHD (CC/CT/TT: No CHD vs. CHD: 22.4/56.0/21.6% vs. 12.0/50.0/38.0%, p = 0.03; for CC/CT vs. TT, p = 0.01). The odds ratio for CHD associated with the TT genotype compared to CC/CT was 2.22 [95%CI: 1.17–4.24], p = 0.01. The TT genotype was also associated with significantly lower plasma TAOS. In males, no association was observed between genotype and CHD risk, but CHD was significantly associated with age, lower HDL, higher triglycerides, higher BMI and cigarette smoking.The TT genotype of this variant is associated with increased CHD risk and lower plasma anti-oxidant defences in females with diabetes. This modest genotype-effect is not apparent in males where traditional risk factors may play a greater role. Journal Article Diabetes Research and Clinical Practice 90 2 196 201 Elsevier Superoxide dismutase; Gene variant; Oxidative stress; Diabetes; CHD; rs4880; Mitochondria; Total anti-oxidant status 31 12 2010 2010-12-31 10.1016/j.diabres.2010.07.009 http://www.sciencedirect.com/science/article/pii/S0168822710003864 COLLEGE NANME COLLEGE CODE Swansea University 2014-12-05T14:51:52.7201029 2012-05-09T09:52:11.5327947 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Danielle Jones 1 Sarah Prior 0000-0001-8703-8092 2 T Tang 3 Steve Bain 4 Steve Hurel 5 Steve Humphries 6 Jeffrey Stephens 7
title Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
spellingShingle Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
Danielle Jones
Sarah Prior
title_short Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
title_full Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
title_fullStr Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
title_full_unstemmed Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
title_sort Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
author_id_str_mv 4d474dbca816c2c209faef443be18a66
cdda101035997acfaa6fdf17097f52b2
author_id_fullname_str_mv 4d474dbca816c2c209faef443be18a66_***_Danielle Jones
cdda101035997acfaa6fdf17097f52b2_***_Sarah Prior
author Danielle Jones
Sarah Prior
author2 Danielle Jones
Sarah Prior
T Tang
Steve Bain
Steve Hurel
Steve Humphries
Jeffrey Stephens
format Journal article
container_title Diabetes Research and Clinical Practice
container_volume 90
container_issue 2
container_start_page 196
publishDate 2010
institution Swansea University
doi_str_mv 10.1016/j.diabres.2010.07.009
publisher Elsevier
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://www.sciencedirect.com/science/article/pii/S0168822710003864
document_store_str 0
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description Mitochondrial superoxide dismutase 2 (SOD2) is an endogenous anti-oxidant enzyme. The rs4880 gene variant results in a C&#62;T substitution, influencing SOD enzymatic activity. This variant has been associated with micro- and macro-vascular complications in diabetes mellitus. Our aim was to examine the association between this variant and coronary heart disease (CHD) risk in a cross-sectional sample of subjects with diabetes.776 Caucasian subjects with diabetes were genotyped. CHD risk, oxidised-LDL and plasma total anti-oxidant status (TAOS) were analysed in relation to genotype. In females, the TT genotype was associated with CHD (CC/CT/TT: No CHD vs. CHD: 22.4/56.0/21.6% vs. 12.0/50.0/38.0%, p = 0.03; for CC/CT vs. TT, p = 0.01). The odds ratio for CHD associated with the TT genotype compared to CC/CT was 2.22 [95%CI: 1.17–4.24], p = 0.01. The TT genotype was also associated with significantly lower plasma TAOS. In males, no association was observed between genotype and CHD risk, but CHD was significantly associated with age, lower HDL, higher triglycerides, higher BMI and cigarette smoking.The TT genotype of this variant is associated with increased CHD risk and lower plasma anti-oxidant defences in females with diabetes. This modest genotype-effect is not apparent in males where traditional risk factors may play a greater role.
published_date 2010-12-31T03:12:12Z
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